SYNERGIC FUNGICIDAL COMBINATIONS UNDERSTANDING AN AMIDINE COMPOUND AND ERGOSTEROL BIOSYNTHESIS INHIB

专利摘要:
combinations of active compounds. the present invention relates to combinations of active compounds, in particular in a composition, which comprises (a) an amidine compound of the formula (i) and another fungicide (b). in addition, the invention relates to a method for curatively or preventively controlling phytopathogenic fungi, the use of a combination according to the invention for seed treatment, a method for protecting seeds and even treated seeds.
公开号:BR112015004968B1
申请号:R112015004968-0
申请日:2013-09-02
公开日:2020-09-15
发明作者:Ulrike Wachendorff-Neumann；Thomas Seitz
申请人:Bayer Cropscience Ag；
IPC主号:

专利说明:

[001] The present invention relates to combinations of active compounds, in particular in a composition, which comprises (A) an amidine compound of the formula (I) and another fungicide (B). In addition, the invention relates to a method for curatively or preventively controlling phytopathogenic fungi, the use of a combination according to the invention for seed treatment, a method for protecting seeds and even treated seeds.
[002] WO-A 03/024 219, WO-A 05/089 547 and WO-A 05/120 234 each disclose fungicidal combinations composed of at least one phenylamidine and at least one other known fungicidally active principle.
[003] WO-A 00/46 184 and WO-A 2007/031513 each disclose the use of arylamidines as fungicides and their preparation from commercially available materials. WO-A 2007/0031513 discloses thiadiazolyloxyphenylamidine compounds of formula (I), methods for producing these compounds from commercially available components and their uses as fungicides.
[004] Since the environmental and economic requirements imposed on current crop protection compositions are increasingly strict with regard, for example, to the spectrum of action, toxicity, selectivity, application rate, waste formation and ease preparation, and given the possibility of possible problems, namely with resistance, it has become a constant effort to develop new compositions, especially fungicidal agents, which in some areas help at least to fulfill the requirements mentioned above. The present invention provides combinations / compositions of active compounds that achieve the stated objective in at least some aspects.
[005] It has now been found, unexpectedly, that the combinations according to the invention not only reinforce, in an additive way, as expected, the spectrum of action against the phytopathogenic agent to be controlled, but also exert a synergistic effect that extends the action range of component (A) and component (B) in two ways. First, the application rates for component (A) and component (B) decrease, while their action remains equally effective. Second, the combination achieves a high degree of phytopathogenic control, even at rates of application so low that the two compounds alone would be totally ineffective. This allows, on the one hand, a substantial widening of the spectrum of phytopathogenic agents that can be controlled and, on the other hand, an increase in the safety of use.
[006] This invention also provides advantageous uses of the combinations according to the invention with a view to controlling weed nematodes from nematode-resistant cultures and / or with a view to increasing yield.
[007] In addition to the synergistic fungicidal and / or nematicidal and / or insecticidal activity, combinations of active compounds according to the invention exhibit other unexpected properties that, in a broader sense, may be called synergistic, such as, for example, example: broadening the spectrum of activity against other insects, nematodes and / or phytopathogenic agents, for example, resistant strains that cause disease in plants; lower application rates of active compounds; adequate infestation control with the aid of combinations of active compounds according to the invention, even at application rates where the individual compounds have practically no or no activity; conducive behavior during formulation or use, for example, during grinding, sifting, emulsifying, dissolving or dispensing; improved storage stability and light stability; advantageous waste formation; improved toxicological behavior or ecotoxicological behavior; improved plant properties, for example, better growth, increased crop yield, better developed root system, larger leaf area, greener leaves, stronger shoots, less seeds needed, lower phytotoxicity, mobilization of the plant's defense system , good compatibility with plants. Thus, the use of combinations or compositions of active compounds according to the invention contributes considerably to keeping young cereals healthy, thus increasing, for example, the winter survival of treated cereal seeds and ensuring quality and yield. In addition, combinations of active compounds according to the invention can contribute to greater systemic action. Even when the individual compounds in the combination do not have adequate systemic properties, combinations of active compounds according to the invention can still exhibit that property. Likewise, combinations of active compounds according to the invention can result in greater long-term effectiveness of the fungicidal action.
[008] Thus, the present invention provides a combination of compounds comprising: (A) at least one compound of formula (I)
in which
[009] R1 is selected from the group consisting of methyl and ethyl;
[010] R2 is selected from the group formed by a Cl atom and a methyl group;
[011] R3 is selected from the group formed by a Cl atom and a methyl group;
[012] R4 is selected from the group formed by hydrogen, halogen or methyl;
[013] R5 is selected from the group formed by hydrogen, halogen or methyl;
[014] and its salts, N-oxides, metal complexes and stereoisomers and
[015] (B-l) at least one other active compound selected from the group consisting of: Group 1:
[016] (B-1.1) Ergosterol biosynthesis inhibitors, for example (1.1) aldimorph (1704-28-5), (1.2) azaconazole (60207-31-0), (1.3) bitertanol (55179- 31-2 ), (1.4) bromuconazole (116255-48-2), (1.5) cyproconazole (113096-99-4), (1.6) diclobutrazol (75736-33-3), (1.7) diphenoconazole (119446-68-3), (1.8) diniconazole (83657-24-3), (1.9) diniconazole-M (83657-18-5), (1.10) dodemorfe (1593-77-7), (1.11) dodemorfe acetate (31717-87-0) , (1.12) epoxiconazole (106325-08-0), (1.13) etaconazole (60207-93-4), (1.14) fenarimol (60168-88-9), (1.15) fenbuconazole (114369-43-6), ( 1.16) fenexamide (126833-17-8), (1.17) phenpropidine (67306-00-7), (1.18) fenpropimorph (67306-03-0), (1.19) fluquinconazole (136426-54-5), (1.20) flurprimidol (56425-91-3), (1.21) flusilazole (85509-19-9), (1.22) flutriafol (76674-21-0), (1.23) furconazole (112839-33-5), (1.24) furconazole- cis (112839-32-4), (1.25) hexaconazole (79983-71-4), (1.26) imazalil (35554-44-0), (1.27) imazalyl sulfate (58594-72-2), (1.28) imibenconazole (86598- 92-7), (1.29) ipconazole (125225-28-7), (1.30) metconazole (125116-23- 6), (1.31) miclobutanil (88671-89-0), (1.32) naphthifine (65472-88- 0), (1.33) nuarimol (63284-71-9), (1.34) oxpoconazole (174212-12-5), (1.35) paclobutrazol (76738-62-0), (1.36) pefurazoate (101903-30-4) , (1.37) penconazole (66246-88- 6), (1.38) piperalin (3478-94-2), (1.39) prochloraz (67747-09-5), (1.40) propiconazole (60207-90-1), ( 1.41) protioconazole (178928-70-6), (1.42) pyributicarb (88678-67-5), (1.43) pyrifenox (88283-41-4), (1.44) quinconazole (103970-75-8), (1.45) simeconazole (149508-90-7), (1.46) spiroxamine (118134-30-8), (1.47) tebuconazole (107534-96-3), (1.48) terbinafine (91161-71- 6), (1.49) tetraconazole ( 112281-77-3), (1.50) triadimefão (43121-43-3), (1.51) triadimenol (55219-65-3), (1.52) tridemorfe (81412-43-3), (1.53) triflumizole (68694- 11-1), (1.54) triforin (26644-46-2), (1.55) triticonazole (131983-72-7), (1.56) uπi∞nazole (83657-22-1), (1.57) uniconazole-p ( 83657-17-4), (1.58) viniconazole (77174-66-4 ), (1.59) voricoπazole (137234-62-9), (1.60) 1- (4-chlorofeπyl) -2- (1H-1,2,4-triazol-1-yl) cycloheptaπol (129586-32-9) , (1.61) 1- (2,2-dimethyl-2,3-dihydro-1 H-inden-1-yl) -1 methyl H-imidazole-5-carboxylate (110323- 95-0), (1.62) N '- {5- (difluoromethyl) -2-methyl-4- [3- (trimethylIsylyl) propoxy] phenyl} -N-ethyl-N-methylimidoformamide (870765-98-3), (1-63) N-ethyl -N-methyl-N '- {2-methyl-5- (trifluoromethyl) -4- [3- (trimethylsilyl) propoxy] phenyl} imidoformamide (870765-96-1), (1.64) 1H-imidazole-1-carbothioate O- [1- (4-methoxyphenoxy) -3,3-dimethylbutan-2-yl] (111226-71-2), (1.65) pyrisoxazole (847749-37-5); Group 2:
[017] BI.2) Respiratory chain inhibitors in complex I or II, for example (2.1) bixafen (581809-46-3), (2.2) boscalide (188425-85-6), (2.3) carboxine (5234- 68-4), (2.4) diflumetorime (130339-07-0), (2.5) fenfurame (24691-80-3), (2.6) fluopiram (658066-35-4), (2.7) flutolanil (66332-96- 5), (2.8) fluxpyroxade (907204-31-3), (2.9) furametpir (123572-88-3), (2.10) furmeciclox (60568-05-0), (2.11) isopyrazame (mixture of epimeric racemate sin 1RS , 4SR, 9RS and 1RS, 4SR, 9SR epimeric racemate) (881685-58-1), (2.12) isopyrazame (anti 1 RS, 4SR, 9SR epimeric racemate), (2.13) isopyrazame (anti 1R, 4S epimeric enantiomer, 9S) (683777-14-2), (2.14) isopyrazame (anti 1S, 4R, 9R epimeric enantiomer) (1130207-91-8), (2.15) isopyrazame (epimeric racemate sin 1 RS, 4SR, 9RS), (2.16 ) isopyrazame (epimeric enantiomer sin 1R, 4S, 9R) (1240879-17-7), (2.17) isopyrazame (epimeric enantiomer sin 1S, 4R, 9S) (1130207-94-1), (2.18) mepronil (55814-41 -0), (2.19) oxycarboxine (5259-88-1), (2.20) penflu hay (494793-67-8), (2.21) pentiopyrade (183675-82-3), (2.22) silkxane (874967-67-6), (2.23) tifluzamide (130000-40- 7), (2.24) 1 - methyl-N- [2- (1,1,2,2-tetrafluoroethoxy) phenyl] -3- (trifluoromethyl) -1 H-pyrazole-4-carboxamide (923953-99-5), (2.25) 3- (difluoromethyl ) -1-methyl-N- [2- (1,1,2,2-tetrafluoroethoxy) phenyl] -1 H-pyrazole-4-carboxamide (923953-98-4), (2.26) 3- (difluoromethyl) - N- [4-fluoro-2- (1,1,2,3,3,3-hexafluoropropoxy) phenyl] -1-methyl-1 H-pyrazole-4-carboxamide (1172611-40-3), (2.27) N- [1- (2,4-dichlorophenyl) -1- methoxypropan-2-yl] -3- (difluoromethyl) -1-methyl-1 H-pyrazole-4-carboxamide (1092400-95-7), (2.28 ) 5,8-difluoro-N- [2- (2-fluoro-4 - {[4- (trifluoromethyl) pyridin-2-yl] oxy} phenyl) ethyl] quinazolin-4-amine (1210070-84-0 ), (2.29) beπzovindiflupir (1072957-71-1), (2.30) N - [(1 S, 4R) -9- (dichloromethylene) -1,2,3,4-tetrahydro-1,4-methanonaftalen-5 -yl] -3- (difluoromethyl) -1-methyl-1 H-pyrazole-4-carboxamide, (2.31) N - [(1 R, 4S) -9- (dichloromethylene) -1,2,3,4- tetrahydro-1,4-methanonaphthalen-5-yl] -3- (difluoro romethyl) -1-methyl-1 H-pyrazole-4-carboxamide, (2.32) 3- (difluoromethyl) -1 - methyl-N- (1,1,3-trimethyl-2,3-dihydro-1H-inden- 4-yl) -1 H-pyrazole-4-carboxamide (141573-94-6), (2.33) 1,3,5-trim ethylN- (1,1,3-trim ethyl I-2,3-d ih idro-1 H-inden-4-yl) - 1 H-pyrazole-4-carboxamide (105113-55-1), (2.34) 1-methyl-3- (trifluoromethyl) -N- (1,1,3 -trimethyl-2,3-dihydro-1 H-inden-4-yl) -1 H-pyrazole-4-carboxamide (105113-24- 4), (2.35) 1-methyl-3- (trifluoromethyl) -N- [(3R) -1,1,3-trimethyl-2,3-dihydro-1 H-inden-4-yl] -1 H-pyrazole-4-carboxamide (1352994-66-1), (2.36) 1- methyl-3- (trifluoromethyl) - N - [(3S) -1,1,3-trimethyl-2,3-dihydro-1 H-inden-4-yl] -1 H-pyrazole-4-carboxamide, (2.37 ) 3- (difluoromethyl) -1-methyl-N - [(3S) -1,1,3-trim ethyl I-2,3-dihydro-1 H-inden-4-yl] - 1 H-pyrazole -4-carboxamide, (2.38) 3- (difluoromethyl) -1-methyl-N - [(3R) -1,1,3-trim ethyl I-2,3-d ih idro-1 H-inden-4- yl] -1 H-pyrazole-4-carboxamide (1352994-67-2), (2.39) 1,3,5-trimethyl-N - [(3R) -1,1,3-trimethyl-2,3-dihydro -1 H-inden-4-yl] -1 H-pyrazole- 4-carb oxamide (1352994-68-3), (2.40) 1,3,5-trimethyl-N - [(3S) -1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl] - 1H-pyrazole-4-carboxamide, (2.41) benodaπil (15310-01- 7), (2.42) 2-chloro-N- (1,1,3-trimethyl-2,3-dihydro-1 H-inden-4 -yl) pyridine-3-carboxamide (119899-14-8), (2.43) 1,3-dimethyl-N- (1,1,3-trimethyl-2,3-dihydro-1 H- inden-4-yl ) -1 H-pyrazole-4-carboxamide, (2.44) 3- (difluoromethyl) -1,5-dimethyl-N- (1,1,3-tri methyl-2,3-dihydro-1 H-inden -4-yl) -1 H-pyrazole-4-carboxamide, (2.45) amidaisofetamide (875915-78-9); Group 3:
[018] BI.3) Respiratory chain inhibitors in complex III, for example (3.1) ametoctradine (865318-97-4), (3.2) amisulbrome (348635-87-0), (3.3) azoxystrobin (131860-33- 8), (3.4) cyzofamide (120116-88-3), (3.5) coumetoxystrobin (850881-30-0), (3.6) coumoxystrobin (850881-70-8), (3.7) dimoxystrobin (141600-52-4) , (3.8) enoxastrobin (238410-11-2), (3.9) famoxadone (131807-57-3), (3.10) phenamidone (161326-34-7), (3.11) fluphenoxystrobin (918162-02-4), ( 3.12) fluoxastrobin (361377-29-9), (3.13) cresoxim-methyl (143390-89-0), (3.14) metominostrobin (133408-50-1), (3.15) orisastrobin (189892-69-1), ( 3.16) picoxystrobin (117428-22-5), (3.17) pyraclostrobin (175013-18-0), (3.18) pyramethostrobin (915410-70-7), (3.19) piraoxystrobin (862588-11-2), (3.20) pyribencarb (799247-52-2), (3.21) triclopyricarb (902760-40-1), (3.22) trifloxystrobin (141517-21-7), (3.23) (2E) -2- (2 - {[6- ( 3-chloro-2-methylphenoxy) -5-fluoropyrimidin-4-yl] oxy} phenyl) -2- (methoxyimino) -N- methylacetamide (308286- 29-5), (3.24) (2E) -2- (methoxyimino) -N-methyl-2- (2 - {[({(1 (E) - 1 - [3- (trifluoromethyl) phenyl] ethylidene} amino) oxy] methyl} phenyl) acetamide (156581 -89-4), (3.25) (2E) -2- (methoxyimino) -N-methyl-2- {2 - [(E) - ({1 - [3- ( trifluoromethyl) phenyl] ethoxy} imino) methyl] phenyl} acetamide (158169-73-4), (3.26) (2E) - 2- {2 - [({[(1 E) -1 - (3 - {[( E) -1-fluoro-2-phenylvinyl] oxy} phenyl) ethylidene] amino} oxy) methyl] phenyl} -2- (methoxyimino) -N- methylacetamide (326896-28-0), (3.27) phenaminostrobin (366815- 39-6), (3.28) 5- methoxy-2-methyl-4- (2 - {[({(1 (E) -1 - [3- (trifluoromethyl) phenyl] ethylidene} amino) oxy] methyl} phenyl) -2,4-dihydro-3H-1,2,4-triazole-3-one (210230-99-2), (3.29) (2E) -2- {2 - [({cyclopropyl [(4-methoxyphenyl) imino] methyl} sulfanyl) methyl] phenyl} -3-methoxyacrylate (149601- 03-6), (3.30) N- (3-ethyl-3,5,5-trimethylcyclohexyl) -3-formamide-2-hydroxybenzamide (226551 -21 -9), (3.31) 2- {2 - [(2,5-dimethylphenoxy) methyl] phenyl} -2-methoxy-N-methylacetamide (173662-97-0), (3.32) 2- { 2 - [(2,5-dimethylphenoxy) methyl] phenyl} -2-methoxy-N-methylacetamide (3946 57-24-0); Group 4:
[019] BI.4) Inhibitors of mitosis and cell division, for example (4.1) benomyl (17804-35-2), (4.2) carbendazim (10605-21-7), (4.3) chlorphenazole (3574-96-7 ), (4.4) dietofencarb (87130-20-9), (4.5) etaboxam (162650-77-3), (4.6) fluopicolide (239110-15-7), (4.7) fuberidazole (3878-19-1), (4.8) pencicurão (66063-05-6), (4.9) thiabendazole (148-79-8), (4.10) thiophanate-methyl (23564-05-8), (4.11) thiophanate (23564-06-9), (4.12) zoxamide (156052-68-5), (4.13) 5-chloro-7- (4-methylpiperidin-1-i) -6- (2,4,6-trifluorophenyl) [1,2 , 4] triazolo [1,5-a] pyrimidine (214706-53-3), (4.14) 3-chloro-5- (6-chloropyridin-3-yl) -6-methyl-4- (2, 4,6-trifluorophenyl) pyridazine (1002756-87-7); Group 5:
[020] BI.5) Compounds with multilocal action, for example (5.1) Bordeaux mixture (8011-63-0), (5.2) captafol (2425-06-1), (5.3) captano (133-06-2 ), (5.4) chlorothalonil (1897-45-6), (5.5) copper hydroxide (20427-59-2), (5.6) copper naphthenate (1338-02-9), (5.7) copper oxide (1317 -39-1), (5.8) copper oxychloride (1332-40-7), (5.9) copper sulfate (2+) ((7758-98-7), (5.10) dichlofluanide (1085-98-9) , (5.11) ditianão (3347-22-6), (5.12) dodina (2439-10-3), (5.13) dodina free base (112-65-2), (5.14) ferbame (14484-64-1) , (5.15) fluorofolpete (719-96-0), (5.16) folpet (133-07-3), (5.17) guazatin (108173-90- 6), (5.18) guazatin acetate (69311-74-6), (5.19) iminoctadine (13516-27-3), (5.20) iminoctadine albesylate (169202-06-6), (5.21) iminoctadine triacetate (57520-17-9), (5.22) mancobre (53988-93-5), (5.23) mancozebe (8018-01-7), (5.24) manebe (12427-38-2), (5.25) metamorph (9006-42-2), (5.26) zinc metamorph (9006-42-2), ( 5.27) oxine-copper (10380-28-6), (5.28) propamidine (104- 32-5 ), (5.29) propineb (12071-83-9), (5.30) sulfur and sulfur preparations including calcium polysulfide (7704-34-9), (5.31) thiram (137-26-8), (5.32) tolylfluanide (731-27-1), (5.33) zineb (12122-67-7), (5.34) zirame (137-30-4), (5.35) anilazine (101-05-3); Group 6:
[021] BI.6) Compounds capable of inducing host defense, for example (6.1) acibenzolar-S-methyl (135158-54-2), (6.2) isothianyl (224049-04-1), (6.3) probenazole ( 27605-76-1), (6.4) thiadinyl (223580-51-6), (6.5) laminarin (9008-22-4); Group 7:
[022] BI.7) Inhibitors of amino acid and / or protein biosynthesis, for example (7.1) andoprime (23951-85-1), (7.2) blasticidin-S (2079-00-7), (7.3) cyprodinil ( 121552-61-2), (7.4) casugamycin (6980-18-3), (7.5) casugamycin hydrochloride hydrate (19408-46-9), (7.6) mepanipyrim (110235- 47-7), (7.7) pyrimethanil ( 53112-28-0), (7.8) 3- (5-fluoro-3,3,4,4-tetramethyl-3,4-dihydroisoquinolin-1-yl) quinoline (861647-32-7), (7.9) oxytetracycline (79-57-2), (7.10) streptomycin (57-92-1); Group 8:
[023] BI.8) ATP production inhibitors, for example (8.1) phentin acetate (900-95-8), (8.2) phentin chloride (639-58-7), (8.3) phentin hydroxide (76- 87 -9), (8.4) siltiofam (175217-20-6); Group 9:
[024] BI.9) Inhibitors of cell wall synthesis, for example (9.1) bentiavalicarb (177406-68-7), (9.2) dimetomorfe (110488-70-5), (9.3) flumorfe (211867-47-9 ), (9.4) iprovalicarb (140923-17-7), (9.5) mandipropamide (374726-62-2), (9.6) polyoxins (11113-80-7), (9.7) polyoxorime (22976-86-9), (9.8) validamycin A (37248-47-8), (9.9) valiphenalate (283159-90-0), (9.10) polyoxin B (19396-06-6); Group 10:
[025] B-1.10) Lipid and membrane synthesis inhibitors, for example (10.1) biphenyl (92-52-4), (10.2) chloroneb (2675-77-6), (10.3) dichlorane (99-30 - 9), (10.4) edifenfos (17109-49-8), (10.5) etridiazole (2593-15-9), (10.6) iodocarb (55406-53-6), (10.7) iprobenfos (26087-47-8 ), (10.8) isoprothiolane (50512-35-1), (10.9) propamocarb (24579-73-5), (10.10) propamocarb hydrochloride (25606-41-1), (10.11) protiocarb (19622-08-3) , (10.12) pyrazophos (13457-18-6), (10.13) fifth (82-68-8), (10.14) tecnazena (117-18-0), (10.15) tolclofos-methyl (57018-04-9) ; Group 11:
[026] B-1.11) Melanin biosynthesis inhibitors, for example (11.1) carpropamide (104030-54-8), (11.2) diclocimete (139920-32-4), (11.3) phenoxaπil (115852-48-7) , (11.4) phthalide (27355-22-2), (11.5) pyroxy (57369-32-1), (11.6) tricyclazole (41814-78-2), (11.7) {3-methyl-1 - [(4 2,2,2-trifluoroethyl-methylbenzoyl) amino] butan-2-yl} carbamate (851524-22-6); Group 12:
[027] B-1.12) Nucleic acid synthesis inhibitors, for example (12.1) benalaxyl (71626-11-4), (12.2) benalaxyl-M (chiralaxyl) (98243-83-5), (12.3) bupirimate ( 41483-43-6), (12.4) clozilacao (67932-85-8), (12.5) dimethyrimol (5221-53-4), (12.6) ethirimol (23947-60-6), (12.7) furalaxil (57646- 30-7), (12.8) himexazole (10004-44-1), (12.9) metalaxyl (57837-19-1), (12.10) metalaxyl-M (mefenoxam) (70630-17-0), (12.11) ofurace (58810-48-3), (12.12) oxadixyl (77732-09-3), (12.13) oxolinic acid (14698-29-4), (12.14) octylinone (26530-20-1); Group 13:
[028] B-1.13) Transduction signal inhibitors, for example (13.1) clozolinate (84332-86-5), (13.2) fenpiclonil (74738-17-3), (13.3) fludioxonil (131341-86-1) , (13.4) iprodione (36734-19-7), (13.5) procymidone (32809-16-8), (13.6) quinoxyphene (124495-18-7), (13.7) vinclozoline (50471-44-8), ( 13.8) proquinazide (189278-12-4); Group 14:
[029] B-1.14) Compounds capable of acting as a decoupler, for example (14.1) binapacril (485-31-4), (14.2) dinocape (131-72-6), (14.3) ferimzone (89269-64- 7), (14.4) fluazinam (79622-59-6), (14.5) meptildinocape (131-72-6); Group 15:
[030] B-1.15) Other compounds, for example (15.1) bentiazole (21564-17-0), (15.2) betoxazine (163269-30-5), (15.3) capsimycin (70694-08-5), (15.4 ) carvona (99-49-0), (15.5) cinometionate (2439-01-2), (15.6) pyrophenone (clazafenone) (688046-61-9), (15.7) cufranebe (11096-18-7), ( 15.8) ciflufeπamide (180409-60-3), (15.9) cymoxanil (57966-95-7), (15.10) cyprosulfamide (221667-31-8), (15.11) dazomete (533-74-4), (15.12) debacarbe (62732-91-6), (15.13) dichlorofeπo (97-23-4), (15.14) dichlomezine (62865-36-5), (15.15) difeπzoquato (49866-87-7), (15.16) difenzoquato sulphate methyl (43222-48-6), (15.17) diphenylamine (122-39-4), (15.18) ecomato, (15.19) feπpirazamiπa (473798-59-3), (15.20) flumetover (154025-04-4) , (15.21) fluoroimide (41205-21-4), (15.22) flusulfamide (106917-52-6), (15.23) flutyanil (304900-25-2), (15.24) fosetil-aluminum (39148-24-8) , (15.25) phosethyl-calcium (39148-20-4), (15.26) fosetyl-sodium (39148-16-8), (15.27) hexachlorobenzene (118-74-1), (15.28) irumamiciπa (81604- 73-1), (15.29) metasulfocarb (66952- 49-6), (15.30) methyl isothiocyanate (556-61-6), (15.31) metrafenone (220899-03-6), (15.32) mildiomiciπa (67527- 71-3), (15.33) natamycin (7681-93-8), (15.34) nickel dimethyldithiocarbamate (15521-65-0), (15.35) nitrotal-isopropyl (10552-74-6), (15.37) oxamocarb ( 917242-12-7), (15.38) oxifeπtiina (34407- 87-9), (15.39) peπtachlorophenol and salts (87-86-5), (15.40) phenothrine (26002-80-2), (15.41) phosphonic acid and its salts (13598-36-2), (15.42) propamocarbosphetylate (237055-17-3), (15.43) propanosine-sodium (88498-02-6), (15.44) pirimorph (868390-90-3) , (15.45) (2E) -3- (4-tert-butylphenyl) -3- (2-chloropyridin-4-yl) -1 - (morfolin-4-yl) prop-2-en-1-one (1231776 -28-5), (15.46) (2Z) -3- (4-tert-butylphenyl) - 3- (2-chloropyridin-4-iI) -1 - (morfolin-4-yl) prop-2-en- 1-one (1231776-29-6), (15.47) pyrrolnitriπa (1018-71-9), (15.48) tebufloquiπa (376645-78-2), (15.49) keyboard software (76280-91-6), (15.50) tolnifaπida (304911-98-6), (15.51) triazoxide (72459-58-6), (15 .52) triclamide (70193-21-4), (15.53) zaryl amide (84527-51-5), (15.54) (3S, 6S, 7R, 8R) -8-benzyl-3 - [({ 3- [(isobutyryloxy) methoxy] -4-methoxypyridin-2-yl} carbonyl) amino] -6-methyl-4,9-dioxo-1,5-dioxoπaπ-7-yl (517875-34-2), ( 15.55) 1- (4- {4 - [(5R) -5- (2,6-difluorophenyl) -4,5-dihydro-1,2-oxazol-3-yl] -1,3-thiazol-2- yl} piperid in-1 -yl) -2- [5-methyl-3- (trifluoromethyl) - 1H-pyrazol-1-yl] ethanone (1003319-79-6), (15.56) 1- (4- {4 - [(5S) -5- (2,6-difluoropheni) -4,5-dihydro-1,2-oxazol-3-yl] -1,3-thiazol-2-i Ipiperid in-1 - il) -2- [5-m ethyl I-3- (trifluoromethyl) -1 H-pyrazol-1-yl] ethanone (1003319-80-9), (15.57) 1- (4- {4- [5- (2,6-d if fluorophenyl) -4,5-dhydro-1,2-oxazol-3-yl] -1,3-thiazol-2-iPiperid in-1 -yl) -2- [5 -methyl-3- (trifluoromethyl) -1 H-pyrazol-1-yl] ethanone (1003318-67-9), (15.58) 1- (4-methoxyphenoxy) -3,3-dimethylbutan-2-yl 1 H- imidazole-1-carboxylate (111227-17-9), (15.59) 2,3,5,6-tetrachloro-4- (methylsulfonyl) pyridine (13108-52-6), (15.60) 2,3-dibutyl-6 -chlorothieno [2,3-d] pyrimidin-4 (3H ) -one (221451-58-7), (15.61) 2,6-dimethyl-1 H, 5H- [1,4] d itinine [2,3-c: 5,6-c '] d ipirrole- 1,3,5,7 (2H, 6H) -tetrone (16114-35-5), (15.62) 2- [5-methyl-3- (trifluoromethyl) -1 H-pyrazol-1-yl] -1 - (4- {4 - [(5R) -5-phenyl-4,5-dihydro-1,2-oxazol-3-yl] -1,3-thiazol-2-iPiperid in-1 -yl) ethanone (1003316-53-7), (15.63) 2- [5-methyl-3- (trifluoromethyl) -1 H-pyrazol-1-yl] -1 - (4- {4 - [(5S) -5-phenyl -4,5-dihydro-1,2-oxazol-3-yl] -1,3-thiazol-2-iPiperid in-1-yl) ethanone (1003316-54-8), (15.64) 2- [ 5-methyl-3- (trifluoromethyl) -1 H-pyrazol-1-yl] -1 - {4- [4- (5-phenyl I-4,5-d ihydro-1,2-oxazol-3- yl) -1,3-thiazol-2-yl] piperidin-1-yljetanone (1003316-51-5), (15.65) 2-butoxy-6-iodo-3-propyl-4H-chromen-4-one (189873 -26-5), (15.66) 2-chloro-5- [2-chloro-1- (2,6-difluoro-4-methoxyphenyl) -4-methyl-1 H-imidazol-5-yl] pyridine (1146788 - 84-2), (15.67) 2-phenylphenol and salts (90-43-7), (15.68) 3- (4,4,5-trifluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1 - il) quinoline (861647-85-0), (15.69) 3,4,5-trichloropyridine-2,6-dicarbonitrile (17824-85-0) , (15.70) 3-chloro-5- (4-chlorophenyl) -4- (2,6-difluorophenyl) -6-methylpyridazine (871513-21-2), (15.71) 4- (4-chlorophenyl) -5- (2,6-difluorophenyl) -3,6-dimethylpyridazine (872847-86-4), (15.72) 5-amino-1,3,4-thiadiazole-2-thiol (2349-67-9), (15.73) 5-chloro-N'-phenyl-N '- (prop-2-in-1-yl) thiophene-2-sulfonfidrazide (164919-01-1), (15.74) 5-fluoro-2 - [(4-fluorobenzyl ) oxy] pyrimidin-4-amine (1174376-11-4), (15.75) 5-fluoro-2 - [(4-methylbenzyl) oxy] pyrimidin-4-amine (1174376-25-0), (15.76) 5 -methyl-6-octyl [1,2,4] triazolo [1,5-a] pyrimidin-7-amine (97228-52-9), (15.77) (2Z) -3-amino-2-cyano-3 -ethylphenylacrylate (39491-78-6), (15.78) N '- (4 - {[3- (4-chlorobenzyl) -1,2,4-thiadiazol-5-yl] oxy} -2,5- dimethiphenyl) -N-ethyl-N-methylimidoformamide (1202781-91-6), (15.79) N- (4-chlorobenzyl) -3- [3-methoxy-4- (prop-2-in-1-yloxy) phenyl ] propanamide (721967-00-6), (15.80) N - [(4-chlorophenyl) (cyano) methyl] -3- [3-methoxy-4- (prop-2-in-1-yloxy) phenyl] propanamide (820214-56-0), (15.81) N - [(5-bromo-3-chloropyridin-2-yl) methyl] -2,4-dichloronicotine (404875-67-8), (15.82) N- [1- (5-bromo-3-chloropyridin-2-yl) ethyl] - 2,4-dichloronicotinamide (404875-68-9), (15.83) N - [1- (5-bromo-3-chloropyridin-2-yl) ethyl] -2-fluoro-4-iodonicotinamide (607351-29-1), (15.84) N - {(E) - [(cyclopropylmethoxy) imino ] [6- (difluoromethoxy) -2,3-difluorophenyl] methyl} -2-phenylacetamide (1172611-45-8), (15.85) N - {(Z) - [(cyclopropylmethoxy) imino] [6- (difluoromethoxy) -2,3-difluorophenyl] methyl} -2-phenylacetamide (862500-87-6), (15.86) N '- {4 - [(3-tert-butyl-4-cyano-1,2-thiazol-5- yl) oxy] -2-chloro-5-methylphenyl} -N-ethyl-N-methylimidoformamide (1239251-85-4), (15.87) N-methyl-2- (1 - {[5-methyl-3- ( trifluoromethyl l) -1 H-pyrazol-1-yl] acetyl (Piperidin-4-yl) -N- (1,2,3,4-tetrahydronaphthalen-1-yl) -1,3-thiazole-4-carboxamide (922514-49-6), (15.88) N-methyl-2- (1 - {[5-methyl-3- (trifluoromethyl) -1 H-pyrazol-1-yl] acetyl] Piperid in-4-yl ) -N - [(1 R) -1,2,3,4- tetrahydronaphthalen-1-yl] -1,3-thiazole-4-carboxamide (922514-07-6), (15.89) N- m ethyl- 2- (1 - {[5-m ethyl-3- (trifluoromethyl) -1 H-pyrazol-1-yl ] acetyl} piperid in-4-yl) -N - [(1S) - 1,2,3,4-tetrahydronaphthalen-1-yl] -1,3-thiazole-4-carboxamide (922514-48-5), (15.90) {6 - [({[(1-methyl-1 H-tetrazol-5-yl) (feπyl) methylene] amino} oxy) methyl] piπdin-2-yl ylcarbamate (1172611-17-4), (15.91) phenazine-1-carboxylic acid (2538-68-3), (15.92) quinoline-8-ol (148-24-3), (15.93) quinolin-8-ol sulfate (2: 1) (134 -31-6), (15.94) {6 - [({[(1-methyl-1 H-tetrazol-5-yl) (phenyl) methylene] amiπo} oxy) methyl] pyridin-2-yl} tert carbamate -butyl (1187836- 93-6), (15.95) 1 -m ethyl l-3- (trifluoromethyl) -N- [2 '- (trifluoromethyl) biphenyl l-2-yl] -1 H- pyrazole-4-carboxamide, (15.96) N- (4'-chlorobiphenyl-2-yl) -3- (difluoromethyl) -1-methyl- 1 H-pyrazole-4-carboxamide, (15.97) N- (2 ', 4'-dichlorobiphenyl-2-yl) -3- (difluoromethyl) - 1-methyl-1 H-pyrazole-4-carboxamide, (15.98) 3- (difluoromethyl) -1-methyl-N- [4'- (trifluoromethi l) biphenyl-2-yl] -1 H-pyrazole-4-carboxamide, (15.99) N- (2 ', 5'-difluorobiphenyl-2-yl) -1-methyl-3- (trifluoromethyl) -1 H-pyrazole-4-carboxamide, (15,100 ) 3- (difluoromethyl) -1-methyl-N- [4 '- (prop-1 -in-1-yl) biphenyl-2-yl] -1 H-pyrazole-4-carboxamide, (15,101) 5 -fluoro-1,3-dimethyl-N- [4 '- (prop-1 -in-1-ii) biphenyl-2-yl] -1 H-pyrazole-4-carboxamide, (15,102) 2-chloro-N - [4 '- (prop-1 -in-1-yl) biphenyl-2-yl] nicotinamide, (15.103) 3- (difluoromethyl) -N- [4' - (3,3-dimethylbut-1 - in-1 -iI) biphenyl-2-yl] -1-methyl-1 H-pyrazole-4-carboxamide, (15.104) N- [4 '- (3,3-d imeti lbut-1 -in-1 - i I) biphenyl-2-yl] -5-fluoro-1,3-dimethyl 1-1 H-pyrazole-4-carboxamide, (15.105) 3- (difluoromethyl) -N- (4'- ethinylbiphenyl-2-yl) -1-methyl-1 H-pyrazole-4-carboxamide, (15.106) N- (4'-ethinylbiphenyl-2-yl) -5-fluoro-1,3-dimethyl-1 H-pyrazole -4-carboxamide, (15.107) 2-chloro-N- (4'-ethynylbiphenyl-2-yl) nicotinamide, (15.108) 2-chloro-N- [4 '- (3,3-dimethylbut-1 -in- 1 -yl) biphenyl-2-yl] nicotinamide, (15,109) 4- (difluoromethyl) -2-methyl-N- [4 '- (trifluoromethyl) biphenyl-2-yl] -1,3-thiazole-5-carboxamide , (15,110) 5-fluoro-N- [4'- (3-hydroxy-3-methylbut-1-in-1-yl) bipheni l-2-yl] -1,3-dim eti 1-1 H-pyrazole-4-carboxamide, (15,111) 2-chloro-N- [4 '- (3-hydroxy-3-methylbut-1-in-1-yl) biphenyl-2-yl] n ichotinamide, (15,112) 3- (difluoromethyl) -N- [4 '- (3-methoxy-3-methylbut-1 -in-1-yl) biphenyl-2-yl] -1-methyl-1 H-pyrazole-4- carboxamide, (15,113) 5-fluoro-N- [4 '- (3-methoxy-3-methylbut-1-in-1 - yl) biphenyl-2-yl] -1,3-dimethyl 1-1 H-pyrazole -4-carboxamide, (15,114) 2-chloro-N- [4 '- (3-methoxy-3-methylbut-1-in-1-yl) biphenyl-2-yl] nicotinamide, (15,115) (5-bromine -2-methoxy-4-methylpyridin-3-yl) (2,3,4-trimethoxy-6-methylphenyl) methanone, (15,116) N- [2- (4 - {[3- (4-chlorophenyl) prop- 2-in-1-yl] oxy} -3-methoxyphenyl) ethyl] -N2- (methylsulfonyl) valinamide (1018965-99-5), (15,117) 4-oxo-4 - [(2-phenylethyl) amino]] butanoic, (15,118) {6 - [({[(Z) - (1-methyl-1 H-tetrazol-5-yl) (phenyl) methylene] amino} oxy) methyl] pyridin-2-yl-carbamate but-3 -in-1-yl, (15,119) 4-amino-5-fluoropyrimidin-2-ol (mesomeric form: 4-amino-5-fluoropyrimidin-2 (1 H) -one), (15,120) 3,4,5 - propyl trihydroxybenzoate, (15,121) 1,3-dimethyl-N- (1,1,3-trimethyl- 2,3-dihydro-1 H-inden-4-yl) -1 H-pyrazole-4-carboxamide (105113-56-2), (15,122) 1,3-dimethyl- N - [(3R) -1, 1,3-trimethyl-2,3-dihydro-1H-inden-4-yl] -1H-pyrazole-4-carboxamide, (15,123) 1,3-di methyl 1N - [(3S) -1,1,3 -trimethi I-2,3-d ihydro-1 H-inden-4-yl] -1 H-pyrazole-4-carboxamide, (15.124) [3- (4-chloro-2-fluorophenyl) -5- ( 2,4-difluorophenyl) -1,2-oxazol-4-yl] (pyridin-3-yl) methanol (1229605-96-2), (15.125) (S) - [3- (4-chloro-2- fluorophenyl) -5- (2,4-difluorophenyl) -1,2-oxazol-4-yl] (pyridin-3-yl) methanol (1229606-46-5), (15.126) (R) - [3- ( 4-chloro-2-fluorophenyl) -5- (2,4-difluorophenyl) -1,2-oxazol-4-yl] (pyridin-3-yl) methanol (1229606-02-3), (15,127) 2- {[3- (2-chlorophenyl) -2- (2,4-difluorophenyl) oxiran-2-yl] methyl} -2,4-dihydro-3H-1,2,4-triazole-3-thione (1342260- 19- 8), (15,128) 1 - {[3- (2-chlorophenyl) -2- (2,4-difluorophenyl) oxiran-2-yl] methyl} -1 H-1,2,4-triazole thiocyanate -5-yl (1342260-26-7), (15,129) 5- (allylsulfanyl) -1 - {[3- (2-chlorophenyl) -2- (2,4-d if fluoropheni I) oxiran-2- il] m eti l} -1 H-1,2,4-triazole (1342260- 41 -6), (15,130) 2- [1 - (2,4-dichlorophenyl) -5-hydroxy-2,6,6-trimethylheptan-4-yl] -2,4-dihydro-3H-1,2, 4-triazole-3-thione, (15,131) 2 - {[rel (2R, 3S) -3- (2-chlorophenyl) -2- (2,4-difluorophenyl) oxiran-2-yl] methyl} -2, 4-dihydro-3H-1,2,4-triazole-3-thioπa, (15,132) 2- {[rel (2R, 3R) -3- (2-chlorophenyl) -2- (2,4-difluorophenyl) oxiran -2-yl] methyl} -2,4-dihydro-3H- 1,2,4-triazole-3-thione, (15,133) 1 - {[rel (2R, 3S) -3- (2-chlorophenyl) thiocyanate ) -2- (2,4-difluorophenyl) oxiran-2-yl] methyl} -1 H-1,2,4-triazol-5-yl, (15,134) 1- {[rel (2R, 3R) thiocyanate -3- (2-chlorophenyl) -2- (2,4-difluorophenyl) oxiran-2-yl] methyl} -1H-1,2,4-triazol-5-yl, (15,135) 5- (alsulfanyl ) -1 - {[rel (2R, 3S) -3- (2-chlorophenyl) -2- (2,4- d if fluorophenyl) oxiran-2-yl] m eti l} -1 H-1,2 , 4-triazole, (15,136) 5- (al isulfanyl) -1 - {[rel (2R, 3R) -3- (2-chlorophenyl) -2- (2,4-difluorophenyl) oxiran-2-yl ] methyl} -1H-1,2,4-triazole, (15,137) 2 - [(2S, 4S, 5S) -1 - (2,4-dichlorophen i I) -5-h idroxy-2,6, 6-trim etieleptan-4-i I] - 2,4-dihydro-3H-1,2,4-triazole-3-thione, (15,138) 2 - [(2R , 4S, 5S) -1- (2,4-dichlorophenyl) - 5-hydroxy-2,6,6-trimethylheptan-4-yl] -2,4-dihydro-3H-1,2,4-triazole-3 -thione, (15,139) 2 - [(2R, 4R, 5R) -1- (2,4-dichlorophenyl) -5-hydroxy-2,6,6-trimethylheptan-4-yl] -2,4-dihydro- 3H-1,2,4-triazole-3-thione, (15,140) 2 - [(2S, 4R, 5R) -1 - (2,4-dichlorophenyl) -5-hydroxy-2,6,6-trim eti eleptan-4-yl] -2,4-d ihydro-3H-1,2,4-triazole-3-thione, (15,141) 2- [(2S, 4S, 5R) -1- (2,4- dichlorophenyl) -5-hydroxy-2,6,6-trimethylheptan-4-yl] -2,4-dihydro-3H-1,2,4-triazole-3-thione, (15,142) 2 - [(2R, 4S , 5R) -1 - (2,4-dichlorophenyl) -5-hydroxy-2,6,6-trimethylheptan-4-yl] -2,4-dihydro-3H-1,2,4-triazole-3-thione , (15,143) 2- [(2R, 4R, 5S) -1- (2,4-dichlorophenyl) -5-hydroxy-2,6,6-trimethylheptan-4-yl] -2,4-dihydro-3H- 1,2,4-triazole-3-thione, (15,144) 2 - [(2S, 4R, 5S) -1 - (2,4-dichlorophenyl) -5-hydroxy-2,6,6-trimethylheptan-4- yl] -2,4-dihydro-3H-1,2,4-triazole-3-thione, (15,145) 2-fluoro- 6- (trifluoromethyl) -N- (1,1,3-trimethyl-2,3 -dihydro-1 H-inden-4-yl) benzamide, (15,146) 3- (4,4-d if fluoro-3,3-d im ethyl I-3,4-d ih idroisoqui no 1-in-1-yl) kinoline, (15,147) N-cyclopropyl-3- (difluoromethyl) -5-fluoro-N- (2-isopropylbenzyl) -1-methyl-1 H-pyrazole-4-carboxamide, (15,148) N-cyclopropyl-N- (2-cyclopropylbenzyl) -3- (difluoromethyl) -5-fluoro-1-methyl-1 H-pyrazole-4-carboxamide, (15,149) N- (2-tert-butylbenzyl) -N- cyclopropyl-3- (difluoromethyl) -5-fluoro-1-methyl-1 H-pyrazole-4-carboxamide, (15,150) N- (5-chloro-2-ethylbenzyl) -N-cyclopropyl-3- ( difluoromethyl) -5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (15,151) N- (5-chloro-2-isopropylbenzyl) -N-cyclopropyl- 3- (difluoromethyl) -5-fluoro- 1-methyl-1 H-pyrazole-4-carboxamide, (15,152) N-cyclopropyl-3- (difluoromethyl) -N- (2-ethyl-5-fluorobeπzil) -5-fluoro-1-methyl-1 H-pyrazole - 4-carboxamide, (15,153) N-cyclopropyl-3- (difluoromethyl) -5-fluoro-N- (5-fluoro-2-isopropyl benzyl) -1-methyl-1 H-pyrazole-4-carboxamide, (15,154) N-cyclopropyl-N- (2-cyclopropyl-5-fluorobenzyl) -3- (difluoromethyl) -5-fluoro-1-methyl-1 H-pyrazole-4-carboxamide, (15,155) N- (2- cyclopeptyl-5-fluorobenzyl) -N-cyclopr opyl-3- (difluoromethyl) -5-fluoro-1-methyl-1 H-pyrazole-4-carboxamide, (15,156) N-cyclopropyl-3- (difluoromethyl) -5-fluoro-N- (2-fluoro-6 -isopropylbenzyl) -1 -methyl-1 H-pyrazole-4-carboxamide, (15.157) N-cyclopropyl-3- (difluoromethyl) -N- (2-ethyl-5-methylbenzyl) -5-fluoro-1-methyl- 1 H-pyrazole-4-carboxamide, (15,158) N-cyclopropyl- 3- (difluoromethyl) -5-fluoro-N- (2-isopropyl-5-methylbenzyl) -1-methyl-1 H-pyrazole-4-carboxamide , (15,159) N-cyclopropyl-N- (2-cyclopropyl-5-methylbenzyl) -3- (difluoromethyl) -5-fluoro-1-methyl-1 H-pyrazole-4-carboxamide, (15,160) N- (2 -tert-butyl-5-methylbenzyl) -N-cyclopropyl-3- (difluoromethyl) -5-fluoro-1-methyl-1 H-pyrazole-4-carboxamide, (15,161) N- [5-chloro-2- ( trifluoromethyl) benzyl] -N-cyclopropyl-3- (difluoromethyl) -5-fluoro-1-methyl-1 H-pyrazole-4-carboxamide, (15,162) N-cyclopropyl-3- (difluoromethyl) -5-fluoro-1 -methyl-N- [5-methyl-2- (trifluoromethyl) benzyl] - 1 H-pyrazole-4-carboxamide, (15.163) N- [2-chloro-6- (trifluoromethyl) beπzil] -N- cyclopropyl-3 - (difluoromethyl) -5-fluoro-1-m ethyl-1 H-pyrazole-4-carboxamide, (15,164) N- [3-chloro-2-fluoro-6- (trifluoromethyl) benzyl] -N-cyclopropyl-3- (difluoromethyl) -5-fluoro-1-methyl -1 H-pyrazole-4-carboxamide. (15,165) N-cyclopropyl-3- (difluoromethyl) -N- (2-ethyl-4,5-dimethylbenzyl) -5-fluoro-1-methyl-1 H-pyrazole-4-carboxamide, (15,166) N-cyclopropyl -3- (difluoromethyl) -5-fluoro-N- (2-isopropylbenzyl) -1-methyl-1 H-pyrazole-4-carbothioamide.
[031] All so-called mixing components of classes (1) to (15) may, if their functional groups so permit, optionally form salts with suitable bases or acids.
[032] When a compound (A) or a compound (B) is present in tautomeric form, it is understood that this compound, before and after, also includes, when applicable, the corresponding tautomeric forms, even when they are not specifically mentioned in each case.
[033] The preferred combinations are the following combinations selected from the group consisting of:
[034] Group 1: (A) + (B-l.1.3); (A) + (B-1.1.4); (A) + (B-1.1.5); (A) + (B-1.1.7); (A) + (B-l.1.12); (A) + (B-1.1.15); (A) + (B-1.1.17); (A) + (B-1.1.18); (A) + (B- 1.1.19); (A) + (B-1.1.22); (A) + (B-1.25); (A) + (B-1.1.29); (A) + (B-l.1.30); (A) + (B-l.1.31); (A) + (B-l.1.37); (A) + (B-l.1.39); (A) + (B-l.1.40); (A) + (B-1.1.41); (A) + (B-1.1.46); (A) + (B-1.1.47); (A) + (B-l.1.49); (A) + (B-1.1.50); (A) + (B-1.1.51); (A) + (B-1.1.55); (A) + (B-1.1.56); (A) + (B-l.1.58);
[035] Group 2: (A) + (B-1.2.1); (A) + (B-1.2.2); (A) + (B-1.2.2); (A) + (B-1.2.6); (A) + (B-1.2.8); (A) + (B-1.2.2); (A) + (B-1.2.2); (A) + (B-1.2.23); (A) + (B-1.2.24); (A) + (B-1.2.2); (A) + (B-1.2.26); (A) + (B-1.2.17); (A) + (B-1.2.2); (A) + (B- 1.2.21); (A) + (B-1.2.22); (A) + (B-1.2.27); (A) + (B-1.2.29); (A) + (B-1.2.22); (A) + (B-1.2.33); (A) + (B-1.2.34); (A) + (B-1.2.35); (A) + (B-1.2.36); (A) + (B-1.2.37); (A) + (B-1.2.38); (A) + (B-1.2.39); (A) + (B-1.2.24);
[036] Group 3: (A) + (B-1.3.3); (A) + (B-1.3.3); (A) + (B-1.3.8); (A) + (B-1.3.12); (A) + (B-1.3.13); (A) + (B-1.3.14); (A) + (B-1.3.15); (A) + (B-1.3.16); (A) + (B-1.3.17); (A) + (B-1.3.22); (A) + (B-1.3.27); (A) + (B-1.3.31); (A) + (B-1.3.32);
[037] Group 5: (A) + (B-1.5.3); (A) + (B-1.5.4); (A) + (B-1.5.11); (A) + (B- 1.5.16); (A) + (B-1.5.23); (A) + (B-1.5.25); (A) + (B-1.5.29); (A) + (B-1.5.31);
[038] Group 6: (A) + (B-I.6.1); (A) + (B-1.6.2);
[039] Group 7: (A) + (B-1.7.7); (A) + (B-1.7.7);
[040] Group 15: (A) + (B-l. 15.61); (A) + (B-l. 15,151).
[041] The most preferred combinations are the following combinations selected from the group formed by:
[042] Group 1: (A) + (B-1.1.5); (A) + (B-l.1.12); (A) + (B-l.1.30); (A) + (B- 1.1.41); (A) + (B-1.1.47);
[043] Group 2: (A) + (B-1.2.1); (A) + (B-1.2.6); (A) + (B-1.2.8); (A) + (B- 1.2.14); (A) + (B-1.2.2); (A) + (B-1.2.26); (A) + (B-1.2.17); (A) + (B-1.2.2); (A) + (B-1.2.21); (A) + (B-1.2.22); (A) + (B-1.2.27); (A) + (B-1.2.29); (A) + (B-1.2.22); (A) + (B-1.2.33); (A) + (B-1.2.34); (A) + (B-1.2.35); (A) + (B-1.2.36); (A) + (B-1.2.37); (A) + (B-1.2.38); (A) + (B-1.2.39); (A) + (B-1.2.24);
[044] Group 3: (A) + (B-1.3.3); (A) + (B-1.3.12); (A) + (B-1.3.16); (A) + (B- 1.3.17); (A) + (B-1.3.22); (A) + (B-1.3.31); (A) + (B-1.3.32);
[045] Group 5: (A) + (B-1.5.4); (A) + (B-1.5.23); (A) + (B-1.5.29);
[046] Group 15: (A) + (B-l. 15.61); (A) + (B-l. 15,151).
[047] From Group 2) the combinations (A) + (B-1.2.1); (A) + (B-1.2.6); (A) + (B- I.2.8); (A) + (B-1.2.21); (A) + (B-1.2.29); (A) + (B-1.2.22); (A) + (B-1.2.33); (A) + (B- I.2.34) are the most preferred.
[048] The most preferred combinations are the following combinations selected from the group formed by:
[049] Group 1: (A) + (B-1.5); (A) + (B-1.12); (A) + (B-1.30); (A) + (B- 1.1.41); (A) + (B-1.1.47);
[050] Group 2: (A) + (B-1.2.1); (A) + (B-1.2.6); (A) + (B-1.2.8); (A) + (B- 1.2.21); (A) + (B-1.2.29); (A) + (B-1.2.22);
[051] Group 3: (A) + (B-1.3.3); (A) + (B-1.3.12); (A) + (B-1.3.16); (A) + (B- 1.3.17); (A) + (B-1.3.22);
[052] Group 5: (A) + (B-1.5.4); (A) + (B-1.5.29);
[053] Group 15: (A) + (B-l. 15.61); (A) + (B-l. 15,151).
[054] In an embodiment of the present invention, the combinations comprise compounds of the formula (I), in which the amidine derivatives are represented by the following formula (la):
in which
[055] R1 is selected from the group consisting of methyl and ethyl;
[056] R4is selected from the group consisting of hydrogen, bromine, chlorine, fluorine or methyl;
[057] and its salts, N-oxides, metal complexes or stereoisomers, and at least one compound (B-1) selected from the group comprising (B-1.1) to (B-l. 15) as mentioned above.
[058] In a more preferred embodiment of the present invention, the combinations comprise compounds of the formula (I), wherein the amidine derivatives are represented by the following formula (lb):
in which
[059] R1 is selected from the group consisting of methyl and ethyl;
[060] R4is selected from the group formed by hydrogen, fluorine or chlorine;
[061] and its salts, N-oxides, metal complexes or stereoisomers, and at least one compound (B-1) selected from the group comprising (B-1.1) to (B-l. 15) as mentioned above.
[062] In a more preferred embodiment of the present invention, the combinations comprise compounds of the formula (I), wherein the amidine derivatives are represented by the following formula (lb):
in which
[063] R1 is selected from the group consisting of methyl and ethyl;
[064] and its salts, N-oxides, metal complexes or stereoisomers, and at least one compound (B-1) selected from the group comprising (B-1.1) to (B-l. 15) as mentioned above.
[065] In a more preferred embodiment of the present invention, the combinations comprise compounds of the formula (I), wherein the amidine derivatives are represented by the following formula (lb):

[066] and its salts, N-oxides, metal complexes or stereoisomers, and at least one compound (B-1) selected from the group comprising (B-1.1) to (B-l. 15) as mentioned above.
[067] Preference is given to combinations according to the invention that are selected from groups 1, 2, 3, 5, 6, 7 and 15, each consisting of the following binary combinations:
[068] Group 1: (A-la) + (B-l. 1.3); (A-la) + (B-l. 1.4); (A-la) + (B-l. 1.5); (A-la) + (B-1.1.7); (A-la) + (B-l.1.12); (A-la) + (B-1.1.15); (A-la) + (B-1.1.17); (A-la) + (B-
[069] Group 2: (A-la) + (B-1.2.1); (A-la) + (B-1.2.2); (A-la) + (B-1.2.3); (A-la) + (B-1.2.6); (A-la) + (B-1.2.8); (A-la) + (B-1.2.2); (A-la) + (B-1.2.2); (A-la) + (B- 1.2.38); (A-la) + (B-1.2.29); (A-la) + (B-1.2.24);
[070] Group 3: (A-la) + (B-1.3.3); (A-la) + (B-1.3.3); (A-la) + (B-1.3.8); (A-la) + (B-1.3.3); (A-la) + (B-1.3.3); (A-la) + (B-1.3.14); (A-la) + (B-1.3.15); (A-la) + (B-1.3.16); (A-la) + (B-1.3.17); (A-la) + (B-1.3.22); (A-la) + (B-1.3.27); (A-la) + (B-1.3.31); (A-la) + (B-1.3.32);
[071] Group 5: (A-la) + (B-1.5.3); (A-la) + (B-1.5.4); (A-la) + (B-1.5.11); (A-la) + (B-1.5.16); (A-la) + (B-1.5.23); (A-la) + (B-1.5.25); (A-la) + (B-1.5.29); (A-la) + (B-1.5.31);
[072] Group 6: (A-la) + (B-1.6.1); (A-la) + (B-1.6.2);
[073] Group 7: (A-la) + (B-l.7.3); (A-la) + (B-l.7.7);
[074] Group 15: (A-la) + (B-l.15.61); (A-la) + (B-l.15.151).
[075] Greater preference is given to combinations according to the invention that are selected from groups 1, 2, 3, 5 and 15, each consisting of the following binary combinations:
[076] Group 1: (A-la) + (B-l.1.5); (A-la) + (B-l.1.12); (A-la) + (B-l.1.30); (A-la) + (B-l.1.41); (A-la) + (B-l.1.47);
[077] Group 2: (A-la) + (B-1.2.1); (A-la) + (B-1.2.6); (A-la) + (B-1.2.8); (A-la) + (B-1.2.24); (A-la) + (B-1.2.2); (A-la) + (B-1.2.26); (A-la) + (B-1.2.27); (A-la) + (B-1.2.2.20); (A-la) + (B-1.2.21); (A-la) + (B-1.2.22); (A-la) + (B-1.2.27); (A-la) + (B-I.2.29); (A-la) + (B-1.2.22); (A-la) + (B-1.2.33); (A-la) + (B-1.2.24); (A-la) + (B-I.2.35); (A-la) + (B-1.2.36); (A-la) + (B-1.2.37); (A-la) + (B-1.2.38); (A-la) + (B-I.2.39); (A-la) + (B-1.2.24);
[078] Group 3: (A-la) + (B-1.3.3); (A-la) + (B-1.3.3); (A-la) + (B-1.3.16); (A-la) + (B-1.3.17); (A-la) + (B-1.3.22); (A-la) + (B-1.3.31); (A-la) + (B-1.3.32);
[079] Group 5: (A-la) + (B-1.5.4); (A-la) + (B-1.5.23); (A-la) + (B-1.5.29);
[080] Group 15: (A-la) + (B-l.15.61); (A-la) + (B-l.15.151).
[081] From Group 2), the combinations (A-la) + (B-1.2.1); (A-la) + (B-1.2.6); (A-la) + (B-1.2.8); (A-la) + (B-1.2.21); (A-la) + (B-1.2.29); (A-la) + (B-1.2.22); (A-la) + (B-1.2.33); (A-la) + (B-1.2.24) are the most preferred.
[082] The most preferred combinations are the following combinations selected from the group consisting of:
[083] Group 1: (A-la) + (B-l.1.5); (A-la) + (B-l.1.12); (A-la) + (B-l.1.30); (A-la) + (B-l.1.41); (A-la) + (B-l.1.47);
[084] Group 2: (A-la) + (B-1.2.1); (A-la) + (B-1.2.6); (A-la) + (B-1.2.8); (A-la) + (B-1.2.21); (A-la) + (B-1.2.29); (A-la) + (B-1.2.22);
[085] Group 3: (A-la) + (B-1.3.3); (A-la) + (B-1.3.3); (A-la) + (B-1.3.16); (A-la) + (B-1.3.17); (A-la) + (B-1.3.22);
[086] Group 5: (A-la) + (B-1.5.4); (A-la) + (B-1.5.29);
[087] Group 15: (A-la) + (B-l.15.61); (A-la) + (B-l.15.151).
[088] In another embodiment of the present invention, combinations are selected from groups 1, 2, 3, 5, 6, 7 and 15, each consisting of the following binary combinations:
[089] Group 1: (A-lb) + (B-l. 1.3); (A-lb) + (B-l. 1.4); (A-lb) + (B-1.1.5); (A-lb) + (B-1.1.7); (A-lb) + (B-l.1.12); (A-lb) + (B-1.1.15); (A-lb) + (B-1.1.17); (A-lb) + (B- 1.1.18); (A-lb) + (B-1.1.19); (A-lb) + (B-l.1.22); (A-lb) + (B-l.1.25); (A-lb) + (B-1.2.39); (A-lb) + (B-l.1.30); (A-lb) + (B-l.1.31); (A-lb) + (B-l.1.37); (A-lb) + (B- 1.2.40); (A-lb) + (B-l.1.40); (A-lb) + (B-l.1.41); (A-lb) + (B-l.1.46); (A-lb) + (B-1.2.41); (A-lb) + (B-l.1.49); (A-lb) + (B-1.1.50); (A-lb) + (B-1.1.51); (A-lb) + (B- 1.2.42); (A-lb) + (B-1.1.56); (A-lb) + (B-1.1.58);
[090] Group 2: (A-lb) + (B-1.2.1); (A-lb) + (B-1.2.2); (A-lb) + (B-1.2.3); (A-lb) + (B-1.2.6); (A-lb) + (B-1.2.8); (A-lb) + (B-1.2.2); (A-lb) + (B-1.2.2); (A-lb) + (B-1.2.13); (A-lb) + (B-1.2.24); (A-lb) + (B-1.2.2); (A-lb) + (B-1.2.26); (A-lb) + (B- 1.2.43); (A-lb) + (B-1.2.2); (A-lb) + (B-1.2.21); (A-lb) + (B-1.2.22); (A-lb) + (B-1.2.44); (A-lb) + (B-1.2.29); (A-lb) + (B-1.2.22); (A-lb) + (B-1.2.33); (A-lb) + (B- 1.2.45); (A-lb) + (B-1.2.35); (A-lb) + (B-1.2.36); (A-lb) + (B-1.2.37); (A-lb) + (B-1.2.46); (A-lb) + (B-1.2.39); (A-lb) + (B-1.2.24);
[091] Group 3: (A-lb) + (B-1.3.3); (A-lb) + (B-1.3.7); (A-lb) + (B-1.3.8); (A-lb) + (B-1.3.3); (A-lb) + (B-1.3.13); (A-lb) + (B-1.3.14); (A-lb) + (B-1.3.15); (A-lb) + (B-1.3.16); (A-lb) + (B-1.3.17); (A-lb) + (B-1.3.22); (A-lb) + (B-1.3.27); (A-lb) + (B-1.3.31); (A-lb) + (B-1.3.32);
[092] Group 5: (A-lb) + (B-1.5.3); (A-lb) + (B-1.5.4); (A-lb) + (B-1.5.11); (A-lb) + (B-1.5.16); (A-lb) + (B-1.5.23); (A-lb) + (B-1.5.25); (A-lb) + (B-1.5.29); (A-lb) + (B-1.5.31);
[093] Group 6: (A-lb) + (B-1.6.1); (A-lb) + (B-1.6.2);
[094] Group 7: (A-lb) + (B-l.7.3); (A-lb) + (B-l.7.7);
[095] Group 15: (A-lb) + (B-l.15.61); (A-lb) + (B-l.15.151).
[096] In another embodiment of the present invention, combinations are selected from groups 1, 2, 3, 5 and 15, each consisting of the following binary combinations:
[097] Group 1: (A-lb) + (B-1.1.5); (A-lb) + (B-l.1.12); (A-lb) + (B-l.1.30); (A-lb) + (B-l.1.41); (A-lb) + (B-l.1.47);
[098] Group 2: (A-lb) + (B-1.2.1); (A-lb) + (B-1.2.6); (A-lb) + (B-1.2.8); (A-lb) + (B-1.2.24); (A-lb) + (B-1.2.2); (A-lb) + (B-1.2.26); (A-lb) + (B-1.2.27); (A-lb) + (B-1.2.2); (A-lb) + (B-1.2.21); (A-lb) + (B-1.2.22); (A-lb) + (B-1.2.27); (A-lb) + (B-I.2.29); (A-lb) + (B-1.2.22); (A-lb) + (B-1.2.33); (A-lb) + (B-1.2.34); (A-lb) + (B-I.2.35); (A-lb) + (B-1.2.36); (A-lb) + (B-1.2.37); (A-lb) + (B-1.2.38); (A-lb) + (B-I.2.39); (A-lb) + (B-1.2.24);
[099] Group 3: (A-lb) + (B-1.3.3); (A-lb) + (B-1.3.3); (A-lb) + (B-1.3.16); (A-lb) + (B-1.3.17); (A-lb) + (B-1.3.22); (A-lb) + (B-1.3.31); (A-lb) + (B-1.3.32);
[100] Group 5: (A-lb) + (B-1.5.4); (A-lb) + (B-1.5.23); (A-lb) + (B-1.5.29);
[101] Group 15: (A-lb) + (B-l.15.61); (A-lb) + (B-l.15.151).
[102] From Group 2), the combinations (A-lb) + (B-1.2.1); (A-lb) + (B-1.2.6); (A-lb) + (B-1.2.8); (A-lb) + (B-1.2.21); (A-lb) + (B-1.2.29); (A-lb) + (B-1.2.22); (A-lb) + (B-1.2.33); (A-lb) + (B-1.2.24) are the most preferred.
[103] The most preferred combinations are the following combinations selected from the group consisting of
[104] Group 1: (A-lb) + (B-1.1.5); (A-lb) + (B-l.1.12); (A-lb) + (B-l.1.30); (A-lb) + (B-l.1.41); (A-lb) + (B-l.1.47);
[105] Group 2: (A-lb) + (B-1.2.1); (A-lb) + (B-1.2.6); (A-lb) + (B-1.2.8); (A-lb) + (B-1.2.21); (A-lb) + (B-1.2.29); (A-lb) + (B-1.2.22);
[106] Group 3: (A-lb) + (B-1.3.3); (A-lb) + (B-1.3.3); (A-lb) + (B-1.3.16); (A-lb) + (B-1.3.17); (A-lb) + (B-1.3.22);
[107] Group 5: (A-lb) + (B-1.5.4); (A-lb) + (B-1.5.29);
[108] Group 15: (A-lb) + (B-l.15.61); (A-lb) + (B-l.15.151).
[109] In another embodiment of the present invention, combinations are selected from groups 1, 2, 3, 5, 6, 7 and 15, each consisting of the following binary combinations:
[110] Group 1: (A-lc) + (B-l.1.3); (A-lc) + (B-1.1.4); (A-lc) + (B-l.1.5); (A-lc) + (B-l. 1.7); (A-lc) + (B-l. 1.12); (A-lc) + (B-l. 1.15); (A-lc) + (B-l. 1.17); (A-lc) + (B-1.1.18); (A-lc) + (B-l.1.19); (A-lc) + (B-l.1.22); (A-lc) + (B-l.1.25); (A-lc) + (B-
[111] Group 2: (A-lc) + (B-1.2.1); (A-lc) + (B-1.2.2); (A-lc) + (B-1.2.2); (A-lc) + (B-1.2.6); (A-lc) + (B-1.2.8); (A-lc) + (B-1.2.2); (A-lc) + (B-1.2.2); (A-lc) + (B-1.2.13); (A-lc) + (B-l.2.14); (A-lc) + (B-l.2.15); (A-lc) + (B-l.2.16); (A-lc) + (B-1.2.17); (A-lc) + (B-l.2.20); (A-lc) + (B-1.2.21); (A-lc) + (B-1.2.22); (A-lc) + (B-I.2.27); (A-lc) + (B-1.2.29); (A-lc) + (B-1.2.22); (A-lc) + (B-1.2.33); (A-lc) + (B-I.2.34); (A-lc) + (B-l.2.35); (A-lc) + (B-1.2.36); (A-lc) + (B-1.2.37); (A-lc) + (B-I.2.38); (A-lc) + (B-1.2.29); (A-lc) + (B-l.2.40);
[112] Group 3: (A-lc) + (B-l.3.3); (A-lc) + (B-l.3.7); (A-lc) + (B-l.3.8); (A-lc) + (B-l.3.12); (A-lc) + (B-l.3.13); (A-lc) + (B-l.3.14); (A-lc) + (B-l.3.15); (A-lc) + (B-1.3.16); (A-lc) + (B-l.3.17); (A-lc) + (B-l.3.22); (A-lc) + (B-l.3.27); (A-lc) + (B-1.3.31); (A-lc) + (B-l.3.32);
[113] Group 5: (A-lc) + (B-1.5.3); (A-lc) + (B-1.5.4); (A-lc) + (B-1.5.11); (A-lc) + (B-1.5.16); (A-lc) + (B-1.5.23); (A-lc) + (B-1.5.25); (A-lc) + (B-1.5.29); (A-lc) + (B-1.5.31);
[114] Group 6: (A-lc) + (B-l.6.1); (A-lc) + (B-l.6.2);
[115] Group 7: (A-lc) + (B-l.7.3); (A-lc) + (B-l.7.7);
[116] Group 15: (A-lc) + (B-l.15.61); (A-lc) + (B-l.15.151).
[117] In another preferred embodiment of the present invention, the combinations are selected from groups 1, 2, 3, 5 and 15, each consisting of the following binary combinations:
[118] Group 1: (A-lc) + (B-l.1.5); (A-lc) + (B-l.1.12); (A-lc) + (B-l.1.30); (A-lc) + (B-l.1.41); (A-lc) + (B-l.1.47);
[119] Group 2: (A-lc) + (B-1.2.1); (A-lc) + (B-1.2.6); (A-lc) + (B-1.2.8); (A-lc) + (B-l.2.14); (A-lc) + (B-l.2.15); (A-lc) + (B-l.2.16); (A-lc) + (B-l.2.17); (A-lc) + (B-
[120] Group 3: (A-lc) + (B-l.3.3); (A-lc) + (B-l.3.12); (A-lc) + (B-l.3.16); (A-lc) + (B-l.3.17); (A-lc) + (B-l.3.22); (A-lc) + (B-l.3.31); (A-lc) + (B-l.3.32);
[121] Group 5: (A-lc) + (B-1.5.4); (A-lc) + (B-1.5.23); (A-lc) + (B-1.5.29);
[122] Group 15: (A-lc) + (B-l.15.61); (A-lc) + (B-l.15.151).
[123] From Group 2), the combinations (A-lc) + (B-1.2.1); (A-lc) + (B-1.2.6); (A-lc) + (B-1.2.8); (A-lc) + (B-1.2.21); (A-lc) + (B-1.2.29); (A-lc) + (B-1.2.22); (A-lc) + (B-1.2.33); (A-lc) + (B-l.2.34) are the most preferred.
[124] The most preferred combinations are the following combinations selected from the group consisting of:
[125] Group 1: (A-lc) + (B-l.1.5); (A-lc) + (B-l.1.12); (A-lc) + (B-l.1.30); (A-lc) + (B-l.1.41); (A-lc) + (B-l.1.47);
[126] Group 2: (A-lc) + (B-1.2.1); (A-lc) + (B-1.2.6); (A-lc) + (B-1.2.8); (A-lc) + (B-1.2.21); (A-lc) + (B-1.2.29); (A-lc) + (B-1.2.22);
[127] Group 3: (A-lc) + (B-1.3.3); (A-lc) + (B-l.3.12); (A-lc) + (B-l.3.16); (A-lc) + (B-l.3.17); (A-lc) + (B-l.3.22);
[128] Group 5: (A-lc) + (B-1.5.4); (A-lc) + (B-1.5.29);
[129] Group 15: (A-lc) + (B-l.15.61); (A-lc) + (B-l.15.151).
[130] In another preferred embodiment of the present invention, combinations are selected from groups 1, 2, 3, 5, 6, 7 and 15, each consisting of the following binary combinations:
[131] Group 1: (A-Id) + (B-I.1.3); (A-Id) + (B-I.1.4); (A-Id) + (B-I.1.5); (A-Id) + (B-I.1.7); (A-Id) + (B-I.1.12); (A-Id) + (B-I.1.15); (A-Id) + (B-I.1.17); (A-Id) + (BI.1.18); (A-Id) + (B-I.1.19); (A-Id) + (B-I.1.22); (A-Id) + (B-I.1.25); (A-Id) + (BI.1.29); (A-Id) + (B-I.1.30); (A-Id) + (B-I.1.31); (A-Id) + (B-I.1.37); (A-Id) + (BI.1.39); (A-Id) + (B-I.1.40); (A-Id) + (B-I.1.41); (A-Id) + (B-I.1.46); (A-Id) + (BI.1.47); (A-Id) + (B-I.1.49); (A-Id) + (B-I.1.50); (A-Id) + (B-I.1.51); (A-Id) + (BI.1.55); (A-Id) + (B-I.1.56); (A-Id) + (B-I.1.58);
[132] Group 2: (A-ld) + (B-1.2.1); (A-ld) + (B-1.2.2); (A-ld) + (B-1.2.3); (A-ld) + (B-1.2.6); (A-ld) + (B-1.2.8); (A-ld) + (B-1.2.2); (A-ld) + (B-1.2.2); (A-ld) + (B-1.2.13); (A-ld) + (B-l.2.14); (A-ld) + (B-l.2.15); (A-ld) + (B-l.2.16); (A-ld) + (B-1.2.17); (A-ld) + (B-1.2.2); (A-ld) + (B-1.2.21); (A-ld) + (B-1.2.22); (A-ld) + (B-I.2.27); (A-ld) + (B-1.2.29); (A-ld) + (B-1.2.22); (A-ld) + (B-1.2.33); (A-ld) + (B-I.2.34); (A-ld) + (B-1.2.35); (A-ld) + (B-1.2.36); (A-ld) + (B-1.2.37); (A-ld) + (B-I.2.38); (A-ld) + (B-1.2.29); (A-ld) + (B-1.2.24);
[133] Group 3: (A-ld) + (B-1.3.3); (A-ld) + (B-l.3.7); (A-ld) + (B-l.3.8); (A-ld) + (B-l.3.12); (A-ld) + (B-l.3.13); (A-ld) + (B-l.3.14); (A-ld) + (B-l.3.15); (A-ld) + (B-l.3.16); (A-ld) + (B-l.3.17); (A-ld) + (B-1.3.22); (A-ld) + (B-l.3.27); (A-ld) + (B-1.3.31); (A-ld) + (B-l.3.32);
[134] Group 5: (A-ld) + (B-1.5.3); (A-ld) + (B-1.5.4); (A-ld) + (B-1.5.11); (A-ld) + (B-1.5.16); (A-ld) + (B-1.5.23); (A-ld) + (B-1.5.25); (A-ld) + (B-1.5.29); (A-ld) + (B-1.5.31);
[135] Group 6: (A-ld) + (B-l.6.1); (A-ld) + (B-l.6.2);
[136] Group 7: (A-ld) + (B-l.7.3); (A-ld) + (B-l.7.7);
[137] Group 15: (A-ld) + (B-l.15.61); (A-ld) + (B-l.15.151).
[138] In another preferred embodiment of the present invention, the combinations are selected from groups 1, 2, 3, 5, and 15, each consisting of the following binary combinations:
[139] Group 1: (A-ld) + (B-l.1.5); (A-ld) + (B-l.1.12); (A-ld) + (B-l.1.30); (A-Id) + (B-1.1.41); (A-ld) + (B-l.1.47);
[140] Group 2: (A-ld) + (B-1.2.1); (A-ld) + (B-1.2.6); (A-ld) + (B-1.2.8); (A-ld) + (B-l.2.14); (A-ld) + (B-l.2.15); (A-ld) + (B-l.2.16); (A-ld) + (B-l.2.17); (A-ld) + (B-1.2.2); (A-ld) + (B-1.2.21); (A-ld) + (B-1.2.22); (A-ld) + (B-1.2.27); (A-ld) + (B-I.2.29); (A-ld) + (B-1.2.22); (A-ld) + (B-1.2.33); (A-ld) + (B-1.2.24); (A-ld) + (B-I.2.35); (A-ld) + (B-1.2.36); (A-ld) + (B-1.2.37); (A-ld) + (B-1.2.38); (A-ld) + (B-I.2.39); (A-ld) + (B-1.2.24);
[141] Group 3: (A-ld) + (B-1.3.3); (A-ld) + (B-l.3.12); (A-ld) + (B-l.3.16); (A-Id) + (B-1.3.17); (A-ld) + (B-1.3.22); (A-ld) + (B-l.3.31); (A-ld) + (B-l.3.32);
[142] Group 5: (A-ld) + (B-1.5.4); (A-ld) + (B-1.5.23); (A-ld) + (B-1.5.29);
[143] Group 15: (A-ld) + (B-l.15.61); (A-ld) + (B-l.15.151).
[144] From Group 2), the combinations (A-ld) + (B-l.2.1); (A-ld) + (B-1.2.6); (A-Ic) + (B-1.2.8); (A-ld) + (B-1.2.21); (A-ld) + (B-1.2.29); (A-ld) + (B-1.2.22); (A-ld) + (B-1.2.33); (A-ld) + (B-l.2.34) are the most preferred.
[145] The most preferred combinations are selected from the group consisting of:
[146] Group 1: (A-ld) + (B-l. 1.5); (A-ld) + (B-l. 1.12); (A-ld) + (B-l. 1.30); (A-ld) + (B-l.1.41); (A-ld) + (B-l.1.47);
[147] Group 2: (A-ld) + (B-1.2.1); (A-ld) + (B-1.2.6); (A-ld) + (B-1.2.8); (A-ld) + (B-1.2.21); (A-ld) + (B-1.2.29); (A-ld) + (B-1.2.22);
[148] Group 3: (A-ld) + (B-1.3.3); (A-ld) + (B-l.3.12); (A-ld) + (B-l.3.16); (A-ld) + (B-l.3.17); (A-ld) + (B-1.3.22);
[149] Group 5: (A-ld) + (B-1.5.4); (A-ld) + (B-1.5.29);
[150] Group 15: (A-ld) + (B-l.15.61); (A-ld) + (B-l.15.151).
[151] The definitions of radicals and the explanations given above in general terms or within preferential ranges may, however, also be combined with each other as desired, that is, spanning between specific ranges and preferential ranges. They apply to final products and correspondingly to their precursors and intermediates. In addition, individual definitions may not apply.
[152] Preference is given to compounds of formula (I), where each radical corresponds to the preferred definitions given above.
[153] Special preference is given to the compounds of formula (I), where each of the radicals corresponds to the most preferred definitions given above.
[154] Very special preference is given to the compounds of formula (I), where each of the radicals corresponds to the even more preferred definitions given above.
[155] In the definitions of the symbols given in the previous formulas, collective terms were used which are generally representative of the following substituents:
[156] Halogen: (also in combinations such as haloalkyl, haloalkoxy, etc.) fluorine, chlorine, bromine and iodine;
[157] Alkyl: (including any combinations such as alkylthio, alkoxy, etc.) univalent radicals of saturated hydrocarbons, straight or branched chain, having 1 to 8 carbon atoms, for example, C 1 -C alkyl, such as methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2- dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl and 1-ethyl- 2-methylpropyl; heptyl, octyl.
[158] Haloalkyl: (including any combinations such as halolalkyl, haloalkoxy, etc.) Straight or branched chain alkyl groups, having 1 to 8 carbon atoms (as specified above), where some or all of the hydrogen atoms in these groups can be substituted by halogen atoms as specified above, for example C1-C3 haloalkyl, such as chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-chloroethyl, 1-chloro-methyl fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2, 2-trichloroethyl, pentafluoroethyl and 1,1,1-trifluoroprop-2-yl.
[159] Alkenyl: univalent radicals of straight or branched chain unsaturated hydrocarbons, having 2 to 8 carbon atoms and a double bond in any position, for example, C2-C6 alkenyl, such as ethylene, 1-propenyl, 2 -propenyl, 1-methylethyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl , 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-1-butenyl, 2-methyl-1-butenyl, 3-methyl-1-butenyl, 1-methyl-2-butenyl, 2 -methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1 , 2-dimethyl-1-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-1-propenyl, 1-ethyl-2-propenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl , 5-hexenyl, 1-methyl-1-pentenyl, 2-methyl-1-pentenyl, 3-methyl-1-pentenyl, 4-methyl-1-pentenyl, 1-methyl-2-pentenyl, 2-methyl-2 -pentenyl, 3-methyl-2-pentenyl, 4-methyl-2-pentenyl, 1-methyl-3-pentenyl, 2-methyl- 3-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentenyl, 1-methyl-4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4- pentenyl, 1,1-dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-1-butyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3- butenyl, 1,3-dimethyl-1-butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-1 - butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 3,3-dimethyl-1-butyl, 3,3-dimethyl-2-butenyl, 1-ethyl-1-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 2-ethyl-1-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2- propenyl, 1-ethyl-1-methyl-2-propenyl, 1-ethyl-2-methyl-1-propenyl and 1-ethyl-2-methyl-2-propenyl.
[160] Cycloalkyl: univalent radical groups of saturated monocyclic hydrocarbons having 3 to 8 ring carbon atoms, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl.
[161] Aryl: aromatic ring, mono-, bi- or tricyclic, substituted or unsubstituted, for example phenyl, naphthyl, anthracenyl (anthryl), phenanthracenyl (phenanthryl).
[162] Heteroaryl: 5- to 7-membered, unsubstituted or substituted, unsaturated, heterocyclic ring containing up to 4 nitrogen atoms or alternatively 1 nitrogen atom and up to 2 other hetero atoms selected from N, O and S, for example 2-furyl , 3-furyl, 2-thienyl, 3-thienyl, 2-pyrrolyl, 3-pyrrolyl, 1-pyrrolyl, 3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 1-pyrazolyl, 1 H-imidazol-2-yl, 1 H-imidazol-4-yl, 1H-imidazol-5-yl, 1 H-imidazol-1-yl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 1 H-1,2,3-triazol-1-yl, 1 H-1,2,3-triazol- 4-yl, 1 H-1,2,3-triazol-5-yl, 2H-1,2,3-triazol-2-yl, 2H-1,2,3-triazol-4-yl, 1 H- 1,2,4-triazol-3-yl, 1 H-1,2,4-triazol-5-yl, 1 H-1,2,4-triazol-1-yl, 4H-1,2,4- triazol-3-yl, 4H-1,2,4-triazol-4-yl, 1 H-tetrazol-1-yl, 1 H-tetrazol-5-yl, 2H-tetrazol-2-yl, 2H-tetrazol- 5-yl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5- yl, 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl, 1,3,4-oxadiazol-2-yl, 1,3,4-thiadiazole-2- yl, 1,2,3-oxadiazol-4-yl, 1,2,3-oxadiazol-5-yl, 1,2,3-thiadiazol-4-yl, 1,2,3-thiadiazol-5-yl, 1,2,5-oxadiazol-3-yl, 1,2,5-thiadiazol-3-yl, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 3-pyridazinyl, 4-pyridazinyl, 2-pyrimidinyl, 4- pyrimidinyl, 5-pyrimidinyl, 2-pyrazinyl, 1,3,5-triazin-2-yl, 1,2,4-triazin-3-yl, 1,2,4-triazin-5-yl, 1,2, 4-triazin-6-yl. Asosicão / Formulation
[163] The present invention also relates to a phytopharmaceutical composition for the control of undesirable microorganisms, especially unwanted fungi and bacteria, which comprises an effective and non-phytotoxic amount of the inventive active ingredients. Fungicidal compositions consisting of auxiliary substances, solvents, carriers, surfactants or agronomically suitable extenders are preferred
[164] In the context of the present invention, "control of harmful microorganisms" means a reduction in infestation by harmful microorganisms compared to the untreated plant, measured as fungicidal efficacy, preferably a 25-50% reduction compared to the plant untreated (100%), more preferably a 40-79% reduction compared to the untreated plant (100%); even more preferably, the infection by harmful microorganisms is completely suppressed (in 70-100%). The control can be curative, that is, to treat already infected plants, or protective, to protect plants that have not yet been infected.
[165] An effective, but non-phytotoxic amount »means an amount of the composition of the invention that is sufficient to satisfactorily control fungal disease of the plant or to eradicate fungal disease completely, and that at the same time does not cause any significant symptoms of phytotoxicity. In general, this application rate can vary over a relatively wide range. It depends on several factors, for example the fungus to be controlled, the plant, the climatic conditions and the components of the inventive compositions.
[166] Suitable organic solvents include all polar and support organic solvents normally used for formulation purposes. Preferably, the solvents are selected from ketones, for example methylisobutyl ketone and cyclohexanone, amides, for example dimethylformamide and amides of alkanecarboxylic acids, for example N, N-dimethyldecanoamide and N, N-dimethyloctanamide, cyclic solvents, for example N-methylpyrrolidone - octylpyrrolidone, N-dodecylpyrrolidone, N-octylcaprolactam, N-dodecylcaprolactam and butyrolactone, strongly polar solvents, for example dimethylsulfoxide and aromatic hydrocarbons, for example xylol, Solvesso ™, mineral oils, for example mineral turpentine, oil, aquilbenz , also esters, for example propylene glycol monomethyl ether acetate, adipic acid dibutyl ester, acetic acid hexyl ester, acetic acid heptyl ester, citric acid tri-n-butyl ester and di-n-butyl ester of phthalic acid , and also alcohols, for example benzyl alcohol and 1-methoxy-2-propanol.
[167] According to the invention, a carrier is a natural or synthetic substance, organic or inorganic, with which the active ingredients are mixed or combined for better applicability, especially for application to plants or parts of plants or seeds. The carrier, which can be solid or liquid, is generally inert and must be suitable for agricultural use.
[168] Useful solid or liquid carriers include, for example, ammonia salts and natural rock powders, such as kaolin, clay, talc, chalk, quartz, atapulgite, montmorillonite or diatomaceous earth, and powdered synthetic rocks, such as such as finely divided silica, alumina and natural or synthetic silicates, resins, waxes, solid fertilizers, water, alcohols, especially butanol, organic solvents, mineral and vegetable oils and their derivatives. Likewise, mixtures of these carriers can be used.
[169] Suitable solid fillers and carriers include inorganic particles, for example carbonates, silicates, sulfates and oxides with an average particle size of 0.005 to 20 pm, preferably 0.02 to 10 pm, for example ammonium sulfate, phosphate ammonia, urea, calcium carbonate, calcium sulfate, magnesium sulfate, magnesium oxide, aluminum oxide, silicon dioxide, the so-called fine particle silica, silica gels, natural or synthetic silicates, and aluminosilicates and plant products such as bran, wood dust / sawdust and cellulose powder.
[170] Solid carriers useful as granules include, for example, crushed and fractionated natural rocks, such as calcite, marble, pumice, sepiolite, dolomite and synthetic granules of inorganic and organic bran, and also granules of organic material, such as sawdust. , coconut husks, corn cobs and tobacco stalks.
[171] Liquefied gas extenders or useful carriers are liquids that are gaseous under normal conditions of temperature and pressure, for example aerosol propellants, such as halogenated hydrocarbons, but also butane, propane, nitrogen and carbon dioxide.
[172] In the formulations, it is possible to use adhesion agents such as carboxymethylcellulose and natural and synthetic polymers in the form of powder, granules or latex, such as arabic gum, polyvinyl alcohol and polyvinyl acetate, or else natural phospholipids, such as cephalins and lecithins , and synthetic phospholipids. Additional additives can be mineral and vegetable oils.
[173] If the extender used is water, one can also use, for example, organic solvents as auxiliary solvents. Useful liquid solvents are essentially: aromatics such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or dichloromethane, aliphatic hydrocarbons such as cyclohexane or paraffins, for example mineral oil, mineral and vegetable oils, alcohols such as butanol or glycol and its ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethylformamide and dimethyl sulfoxide, and also water.
[174] The compositions of the invention may further comprise other components, for example, surfactants. Suitable surfactants are emulsifiers and / or foams, dispersants or wetting agents with ionic or non-ionic properties, or mixtures of these surfactants. Examples include salts of polyacrylic acid, salts of lignosulfonic acid, salts of phenosulfonic acid or naphthalenesulfonic acid, polycondensates of ethylene oxide with fatty alcohols, fatty acids or fatty amines, substituted phenols (preferably alkylphenols or arylphenols), salts of sulfosuccinic esters, derivatives of taurines (preferably alkyl laurates), phosphoric esters of alcohols or polyethoxylated phenols, esters of polyol fatty acids and derivatives of compounds containing sulphates, sulphonates and phosphates, examples being ethers of alkylaryl polyglycol, alkylsulfonates, alkylsulfates, arylsulfonates, protein hydrolysates, residual lignin sulphite and methylcellulose mixtures. The presence of a surfactant is advantageous if one of the active ingredients and / or one of the inert carriers is not soluble in water and the application takes place in water. The proportion of surfactants varies between 5 and 40% by weight of the inventive composition.
[175] Suitable surfactants (adjuvants, emulsifiers, dispersants, protective colloids, wetting and adherent agents) include all common ionic and non-ionic substances, for example ethoxylated nonylphenols, polyalkylene glycolether of linear or branched alcohols, products of the reaction of alkyl phenols with ethylene oxide and / or propylene oxide, fatty acid amine reaction products with ethylene oxide and / or propylene oxide, in addition, fatty acid esters, alkylsulfonates, alkylsulfates, alkylsulfates, alkylethers phosphates, arylsulfates, ethoxylated arylalkylphenols, for example tristyrylphenol ethoxylates, in addition, ethoxylated and propoxylated arylalkylphenols such as sulfated or phosphateed arylalkylphenol ethoxylates and ethoxy- and propoxylates. Other examples of natural and synthetic water-soluble polymers are lignosulfonates, gelatin, gum arabic, phospholipids, starch, modified hydrophobic starch and cellulose derivatives, in particular cellulose ester and cellulose ether, in addition, polyvinyl alcohol, polyvinyl acetate, polyvinylpyrrolidone, polyacrylic acid, polymethacrylic acid and (meth) acrylic acid co-polymerisers and (meth) acrylic acid esters, in addition, methacrylic acid co-polymerisers and methacrylic acid esters neutralized with alkali metal hydroxides, and also products condensation of naphthalenesulfonic acid salts optionally substituted with formaldehyde.
[176] It is possible to use dyes such as inorganic pigments, for example iron oxide, titanium oxide and Prussian blue, organic dyes like alizarin dyes, azo dyes and metallophthalocyanine dyes, and oligonutrients like iron, manganese, boron salts, copper, cobalt, molybdenum and zinc.
[177] Anti-foam agents that may be present in formulations include, for example, silicone emulsions, long-chain alcohols, fatty acids and their salts, as well as fluororganic substances and mixtures thereof.
[178] Examples of thickeners include polysaccharides, such as xanthan gum or Veegum, silicates, for example atapulgite, bentonite, as well as fine particle silica.
[179] If necessary, other components may also be present, for example protective colloids, binders, adhesives, thickeners, thixotropic substances, penetrants, stabilizers, sequestrants and complexing agents. In general, the active ingredients can be combined with any solid or liquid additive commonly used for formulation purposes.
[180] The active ingredients or compositions of the invention can be used as such or, depending on their specific physical and / or chemical properties, in the form of formulations or forms of use prepared from them, such as aerosols, capsule suspensions , cold fogging concentrates, hot fogging concentrates, encapsulated granules, fine granules, fluid concentrates for seed treatment, ready-to-use solutions, dustable powders, emulsifiable concentrates, oil-in-water emulsions, water-in-water emulsions oil, macrogranules, microgranules, oil-dispersible powders, oil-miscible fluid concentrates, oil-miscible fluids, gas (under pressure), gas-generating products, foams, pastes, pesticide-coated seeds, suspension concentrates, suspoemulsion concentrates, soluble concentrates, suspensions, wettable powders, soluble powders, powders and granules, granules or tablets soluble in water and dispersible in water, after sol water-soluble and water-dispersible for the treatment of seeds, wettable powders, natural products and synthetic substances impregnated with the active ingredient, as well as microencapsulations in polymeric substances and in seed coating materials, as well as hot and ultra low volume cold nebulization (UBV).
[181] The compositions of the invention include not only ready-to-use formulations, which can be applied to the plant or seeds by means of a suitable device, but also commercial concentrates that must be diluted with water before use. Common applications are, for example, dilution in water and subsequent spraying of the resulting spray liquor, application after dilution in oil, direct application without dilution, seed treatment or application of granules to the soil.
[182] The compositions and formulations of the present invention generally contain from 0.05 to 99% by weight, from 0.01 to 98% by weight, preferably from 0.1 to 95% by weight, more preferably from 0 , 5 to 90% by weight, more preferably 10 to 70% by weight of the active ingredient. For special applications, for example for the protection of wood and wood products, inventive compositions and formulations generally contain from 0.0001% to 95% by weight, preferably from 0.001 to 60% by weight of the active ingredient.
[183] The content of active ingredient in application forms prepared from commercial formulations can vary over a wide range. The concentration of the active ingredients in the application forms is generally from 0.000001 to 95% by weight, preferably from 0.0001 to 2% by weight.
[184] The above formulations can be prepared in a known manner, for example, by mixing the active ingredients with at least one common extender, solvent or diluent, adjuvant, emulsifier, dispersant, and / or binder or fixative, wetting agent, water repellent , if necessary desiccants and UV stabilizers and, if necessary, dyes and pigments, antifoaming agents, preservatives, organic and inorganic thickeners, adhesives, gibberellins, other processing aids and also water. Depending on the type of formulation, additional processing steps may be necessary, for example wet milling, dry milling and granulation.
[185] The inventive active ingredients can be present by themselves or in their (commercial) formulations and in the forms of use prepared from these formulations, as a mixture with other (known) active ingredients, such as insecticides, attractants, sterilizers, bactericides, acaricides, nematicides, fungicides, growth regulators, herbicides, fertilizers, protective agents and / or semi-chemicals.
[186] The treatment of plants and plant parts with the active ingredients or compositions according to the invention is carried out directly or by action in their proximity, habitat or storage space, by the usual methods of treatment, for example immersion, spraying, atomization, irrigation, evaporation, dusting, nebulization, broadcasting, foam, painting, spreading, watering (drenching), drip irrigation and, in the case of propagating material, especially in the case of seeds, also by dry treatment of the seeds , wet treatment of seeds, treatment of suspensions, inlay, coating with one or more layers, etc. It is also possible to apply the active ingredients by the ultra low volume method or to inject the preparation of the active ingredient or the active ingredient itself into the soil. Plant / Crop Protection
[187] The active ingredients or compositions of the present invention have a potent microbicidal activity and can be used in the control of undesirable microorganisms, such as fungi and bacteria, to protect crops and materials.
[188] The invention also relates to a method for controlling undesirable microorganisms, characterized in that the inventive active ingredients are applied in phytopathogenic fungi, phytopathogenic bacteria and / or in their habitat.
[189] In the control of phytopathogenic fungi for crop protection, fungicides can be used. These are characterized by an excellent efficacy against a wide spectrum of phytopathogenic fungi, including soil pathogens, in particular elements of the classes Plasmodiophoromycetes, Peronosporomycetes (sin .: Oomycetes), Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes and Deuteromycetes imperfecti). Some fungicides are systemically active and can be used to protect plants as foliar fungicides, seed treatment or soil. In addition, they are suitable for combating infesting fungi of, in particular, wood or plant roots.
[190] Bactericides can be used in crop protection to control Pseudomonadaceae, Rhizobiaceae, Enterobacteriaceae, Corynebacteriaceae and Streptomycetaceae.
[191] Non-limiting examples of pathogens of fungal diseases that can be treated according to the invention include:
[192] diseases caused by powdery mildew pathogens, for example Blumeria species, for example Blumería graminis', Podosphaera species, for example Podosphaera leucotricha ', Sphaerotheca species, for example Sphaerotheca fuliginea' Uncinula species, for example Uncinula necator ,
[193] diseases caused by pathogens of rust disease, for example Gymnosporangium species, for example Gymnosporangium sabinae ', Hemileia species, for example Hemileia vastatrix', Phakospsora species, for example Phakopsora pachyrhizi and Phakopsora meibomiae ', species of Puccinia, for example Puccinia recondite, P. triticina, P. graminis or P. sthiformis ', species of Uromyces, for example Uromyces appendiculatus',
[194] diseases caused by pathogens in the Oomycetes group, for example Albugo species, for example Albugo Candida, Bremia species, for example Bremia latucae ', Peronospora species, for example Peronospora pisi and P. brassicae', species of Phytophtora, for example Phytophtora infestans', Plasmopara species, for example Plasmopara vitícola 'Pseudoperonospora species, for example Pseudoperonospora humuli or Pseudoperonospora cubensis', Pythium species, for example Pythium ultimunr,
[195] Leaf spot diseases and leaf wilt diseases caused by Alternaria species, for example Alternaria solanr, Cercospora species, for example Cercospora beticola ', Cladiosporium species, for example Cladiosporium cucumeriem a Cochliobolus species, for example Cochliobolus sativus (conidia form: Drechslera, sin .: Helminthospohum), Cochliobolus miiabeanus] Colletotrichum species, for example Colletotrichum lindemuthiaem a Cycloconium species, for example Cycloconium oleagiem a Diaporthe species, for example Diaporthe citrr, Els species for example Elsinoe fawcettii ', Gloeosporium species, for example Gloeosporium laeticolor, Glomerella species, for example Glomerella cingulata', Guignardia species, for example Guignardia bidwellir, Leptosphaeria species, for example Leptosphaeria maculans and Leptosphaeria nodoruirrr, species, for example Magnaporthe grisea., Microdochium species, for example plo Microdochium nivale ', Mycosphaerella species, for example Mycosphaerella gramnicola, M. arachidicola and M. fijiensis', Phaeosphaeria species, for example Phaeosphaeria nodorunr, Pyrenophora species, for example Pyrenophora teres, Pyrenophora tritici repentis species,' for example Ramularia collo-cygni, Ramularia areola ', Rhynchosporium species, for example Rhynchosporium secalis; Septoria species, for example Septoria apii, Septoria lycopersir, Typhula species, for example Typhula incarnata ', Venturia species, for example Venturia inaequalis',
[196] Root and stem diseases, for example by Corticium species, for example Corticium graminaaruirr, Fusarium species, for example Fusarium oxysporunr, Gaeumannomyces species, for example Gaeumannomyces graminis', Rhizoctonia species, for example Rhizoctonia solanr, species Sarocladium, for example Sarocladium oryzae ', Sclerotium species, for example Sclerotium oryzae', Tapesia species, for example Tapesia acuformis ', Thielaviopsis species, for example Thielaviopsis basicola',
[197] Ear and panicle diseases (including ears of corn) caused, for example by Alternaria species, for example Alternaria spp .; Aspergillus species, for example Aspergillus flavus', Cladosporium species, for example Cladiosporium cladosporioides', Claviceps species, for example Claviceps purpurea ', Fusarium species, for example Fusarium culmorunr, Gibberella species, for example Gibberella zeae; Monographella species, for example Monographella nivalis; Septoria species, for example Septoria nodorum;
[198] Diseases caused by the coal fungus, for example Sphacelotheca species, for example Sphacelotheca reiliana; Tilletia species, for example Tilletia caries; Urocystis species, for example Urocystis occulta ', Ustilago species, for example Ustilago nuda, U. nuda tritici;
[199] Fruit rot diseases, for example, Aspergillus species, for example Aspergillus flavus; Botrytis species, for example Botrytis cinerea; Penicillium species, for example Penicillium expansum and Penicillium purpurogeem one; Sclerotinia species, for example Sclerotinia sclerotiorunr, Verticillium species, for example Verticillium alboatrum;
[200] Diseases of decomposition, mold, wilting, rot of seeds and soil and rotting of seedlings caused, for example, by species of Alternaria, for example Alternaria brassicicola; Aphanomyces species, for example Aphanomyces euteiches; Ascochyta species, for example Ascochyta lentis; Aspergillus species, for example Aspergillus flavus; species of Cladosporium, for example Cladosporium herbarum ', species of Cochliobolus, for example Cochliobolus sativus; (form of conidia: Drechslera, Bipolaris sin .: Helminthosporíum); Colletotrichum species, for example Colletotrichum coccodes; Fusarium species, for example Fusarium culmorunr, Gibberella species, for example Gibberella zeae; Macrophomina species, for example Macrophomina phaseolina; Monographella species, for example Monographella nivalis; Penicillium species, for example Penicillium expansum; Phoma species, for example Phoma lingam; Phomopsis species, for example Phomopsisoyae; Phitofthora species, for example Phitofthora cactorum; Pyrenophora species, for example Pyrenophora graminea; Pyricularia species, for example Pyricularia oryzae; Pythium species, for example Pythium ultimum; Rhizoctonia species, for example Rhizoctonia solani; Rhizopus species, for example Rhizopus oryzae ', Sclerotium species, for example Sclerotium rolfsii; Septoria species, for example Septoria nodorunr, Typhula species, for example Typhula incarnata ', Verticillium species, for example Verticillium dahliae',
[201] Diseases of cancer, galls and witches 'broom caused, for example, by species of Nectria, for example Nectria galllgena',
[202] Withering diseases caused, for example, by species of Monilinia, for example Monilinia laxa;
[203] Diseases of leaf blistering or rolling caused, for example, by Exobasidium species, for example Exobasidium vexans; Taphrina species, for example Taphrina deformans',
[204] Diseases of degradation of woody plants caused, for example, by Esca disease, for example Phaeomoniella clamydospora, Phaeoacremonium aleophilum and Fomitiporia mediterrânea ', Eutypa dyeback caused by, for example, Eutypa lata', Ganoderma diseases caused, for example Ganoderma boninense-, Rigidoporus diseases caused, for example, by Rigidoporus lignosus
[205] Diseases of flowers and seeds caused, for example, by species of Botrytis, for example Botrytis cinerea;
[206] Tuber diseases caused, for example, by Rhizoctonia species, for example Rhizoctonia solani ', Helminthosporium species, for example Helminthosporium solani;
[207] Cabbage colt diseases caused, for example, by species of Plasmodiophora, for example Plamodiophora brassicae.
[208] Diseases caused by bacterial pathogens, for example, by Xanthomonas species, for example Xanthomonas campestris pv. oryzae ', species of Pseudomonas, for example Pseudomonas syringae pv. lachrymans', species of Erwinia, for example Erwinia amylovora.
[209] Preferably, the following soy diseases are controlled:
[210] Fungal diseases on leaves, stems, pods and seeds, for example, leaf spot by Alternaria (Alternaria spec, atrans tenuíssima), anthracnose (Colletotrichum gloeosporoides dematium var. Truncatum), brown spot (Septoria glycines), spot and burning leaf by Cercospora (Cercospora kikuchii), leaf burning by Choanephora (Choanephora infundibulifera trispora (sin.)), leaf spot by Datuliophora (Datuliophora gyicines), downy mildew (Peronospora manshurica), burning by Drechslera (glycerin), leaf spotting (Drechslera) frog (Cercospora sojina), leaf spot by Leptosphaerulina (Leptosphaerulina trifoli), leaf spot by Phyllosticta (Phyillostictaoyaecola), pod and stem burning (Phomopsisoyae), powdery mildew (Microsphaera diffusa), leaf spot by Pyrenochaeta (Pyrenochaeta), Pyrenochaeta (Pyrenochaeta), Pyrenochaeta (Pyrenochaeta) burning of aerial parts, foliage and mycelia web by Rhizoctonia (Rhizoctonia solani), rust (Phakospora pachyrhizi, Phakopsora meibomiae), stony (Sphaceloma gyicines), burning fo liar by Stemphylium (Stemphylium botryosum), target spot (Corynespora cassiicola).
[211] Fungal diseases of the root and stem base, for example, black root rot (Calonactria crotalariae), coal rot (Macrophomina phaseolina), burning or wilting, root rot and pod and colon rot by Fusarium (Fusarium oxysporum, Fusarium Orthoceras Fusarium semitectum, Fusarium equiseti), root rot by Mycoleptodiscus (Mycoleptodiscus terrestris), Neocosmospora (Neocosmopspora vasinfeta), burning of the pod and stem (Diaporthe phaseolorum), stem cancer (Diaporthe phaseolorum, var. Phytophthora (Phytophthora megasperma), brown stem rot (Phialofora gregata), Pythium rot (Phythium afanidermatum, Pythium irregulare, Phythium debaryaem urn, Phythium myriotylum, Phythium ultimum, root rot, root decay, root rot Rhizoctonia solani), stem decomposition by Sclerotinia (Sclerotinia sclerotiorum), burning (Southern blight) by Sclerotinia (Sclerotinia rolfs ii), root rot by Tielaviopsis (Tielaviopsis basicola).
[212] The fungicidal compositions of the invention can be used as curative or protective / preventive control of phytopathogenic fungi. The invention, therefore, also relates to curative and protective methods for controlling phytopathogenic fungi through the use of the active ingredients or compositions of the invention, which are applied to the seed, plant or parts of the plant, and to the fruit or soil in which the plants grow.
[213] The fact that the active ingredients are well tolerated by plants at the concentrations necessary to control their diseases allows treatment of parts of plants above the ground, propagating material and seeds, and the soil.
[214] According to the invention, all plants and parts of plants can be treated. Plants are understood to mean all plants and plant populations, such as desirable and undesirable wild plants, cultivars and plant varieties (subject to protection of the plant variety or breeder's right). Cultivars and plant varieties can be plants obtained by conventional propagation and reproduction methods that can be assisted or complemented by one or more biotechnological methods, such as using double-haploids, protoplast fusion, random and directed mutagenesis, molecular or genetic markers , or methods of bioengineering and genetic engineering. Plant parts mean all parts above ground and below ground and plant organs, such as buds, leaves, flowers and roots, examples of which are leaves, needles, stems, trunks, flowers, fruit bodies, fruits and seeds, and also roots, tubers and rhizomes. Plant parts also include crops and material for vegetative and generative propagation, for example, seedlings, tubers, rhizomes, cuttings and seeds.
[215] When the active ingredients of the invention are well tolerated by plants and in addition have a toxicity favorable to homeothermia and good tolerance to the environment, then they are appropriate to protect plants and plant organs, as well as to improve the yield of crops and the quality of the material collected. Preferably, they can be used as crop protection compositions. They are active against normally sensitive and resistant species and in all or some stages of development.
[216] The plants that can be treated according to the invention include the following main crop plants: corn, soy, beans, alfalfa, cotton, sunflower, Brassica oil seeds such as Brassica napus (for example canola, rapeseed), Brassica rapa, B. juncea (for example, rapeseed) and Brassica carinata, Arecaceae sp. (eg palm oil, coconut), rice, wheat, sugar beet, sugar cane, oats, rye, barley, millet and sorghum, triticale, flax, nuts, grapes and vines, various fruits and vegetables of various botanical taxa, for example Rosaceae sp. (eg fruits of pome fruits, such as apples and pears, but also stone fruits such as apricots, cherries, almonds, plums and peaches and berries such as strawberries, raspberries, red and black currants and gooseberries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp. (e.g. olive tree), Atinidaceae sp., Lauraceae sp. (eg avocado, cinnamon, camphor), Musaceae sp. (for example, banana trees and plantations), Rubiaceae sp. (for example coffee), Teaceae sp. (for example here), Sterculiceae sp., Rutaceae sp. (for example, lemons, oranges, tangerines and grapefruits), Solanaceae sp. (for example, tomatoes, potatoes, peppers, capsicum, eggplants, tobacco), Liliaceae sp., Compositae sp. (for example, lettuce, artichoke and cicada - including cicicar root, endive or common cicada), Umbelliferae sp. (for example carrots, parsley, celery and celeriac), Cucurbitaceae sp. (eg cucumbers - including cornicons, pumpkins, watermelons, gourds and melons), Alliaceae sp. (for example leek and onion), Cruciferae sp. (eg white cabbage, red cabbage, broccoli, cauliflower, Brussels sprouts, pak coi, kohlrabi, radishes, horseradish, watercress and kinesi cabbage), Leguminosae sp. (for example peanuts, peas, lentils and beans - for example common beans and broad beans), Cenopodiaceae sp. (for example chard, fodder beet, spinach, beet), Linaceae sp. (for example hemp), Cannabeacea sp. (for example cannabis), Malvaceae sp. (for example okra, cocoa), Papaveraceae (for example poppy), Asparagaceae (for example asparagus); useful plants and ornamental plants of the garden and forest, including grass, lawn, grass and Stevia rebaudiana ', and in each case, the genetically modified types of these plants.
[217] In particular, the compounds, mixtures and compositions according to the invention are suitable for controlling the following plant diseases:
[218] Albugo spp. (white rust) of ornamental plants, horticultural crops (for example, A. Candida) and sunflowers (for example, A. tragopogonis); Alternaria spp. (black spot disease) in vegetables, rapeseed (for example, A. brassicola or A. brassicae), sugar beet (for example, A. tenuis), fruits, rice, soy and potatoes (for example, A. solani or A alternate) and tomatoes (for example, A. solani or A. alternata) and Alternaria spp. (alternariosis) in wheat; Afanomices spp. on beets and vegetables; Ascochyta spp. in cereals and vegetables, for example, A. tritici (ascochyta leaf blight) in wheat and A. hordei in barley; Bipolaris and Drechslera spp. (teleomorph: Cochliobolus spp.), for example, leaf spot diseases {D. maydis and B. zeicola) on maize, for example, glume patch (B. sorokiniana) on cereals and, for example, B. oryzae on rice and grass; Blumeria (old name: Erysiphe) graminis (powdery mildew) in cereals (for example, wheat or barley); Botryosphaeria spp. (European scoriosis) on vines (for example, B. obtusa); Botrytis cinerea (teleomorph: Botrytis fuckeliana: gray rot) in soft fruit and pome (strawberries, among others), vegetables (lettuce, carrots, celeriac and cabbage, among others), rapeseed, flowers, vines, forest crops and wheat ( ear mold); Bremia latucae (downy mildew) on lettuce; Ceratocystis (sin .: Ophiostoma) spp. (blue spot fungus) in deciduous and coniferous trees, for example, C. ulmi (Dutch elm disease) in elm trees; Cercospora spp. (Cereospora leaf spot) on maize (for example, C. zeae-maydis), rice, sugar beet (for example, C. beticola), sugar cane, vegetables, coffee, soy (for example, C. sojína or C. kikucil) and rice; Cladosporium spp. in tomatoes (for example, C. fulvum: tomato cladosporiosis) and cereals, for example, C. herbarum (ear rot) in wheat; Purple claviceps (ergot) in cereals; Cochliobolus (anamorph: Helminthosporium or Bipolaris) spp. (leaf spot) on corn (eg, C. carboem um), cereals (eg, C. sativus, anamorph: B. sorokiniana: glume spot) and rice (eg, C. miyabeanus, anamorph: H. oryzae ); Colletotrichum (teleomorph: Glomerella) spp. (anthracnose) on cotton (for example, C. gossypii), corn (for example, C. gramnicola: stem rot and anthracnose), soft fruit, potato (for example, C. coccodes: wilting diseases), beans (for for example, C. lindemuthiaem um) and soy (for example, C. truncatum) ', Corticium spp., for example, C. sasakii (' scabbard ') in rice; Corynespora cassiicola (leaf spot) in soybeans and ornamental plants; Cycloconium spp., For example, C. oleagiem one in olive trees; Cylindrocarpon spp. (eg cancer of fruit trees or black vine disease, teleomorph: Nectria or Neonectria spp.) in fruit trees, grapevines (eg C. liriodendn; teleomorph: Neonectria liriodendri black foot disease) and many ornamental trees; Dematophora (teleomorph: Rosellinia) necatrix (root / stem rot) in soybean; Diaporthe spp, for example, D. phaseolorum (stem disease) in soybeans; Drechslera (sin .: Helmintosporium, teleomorph: Pyrenophora spp.) In corn, cereals, such as barley (for example, D. teres, reticular spot) and wheat (for example, D. tritici-repentis: DTR leaf spot), rice and grass; Esca disease (decline of new vines, apoplexy) in vines, caused by Formitiporia (sin .: Phellinus) punctata, F mediterrane Phaeomoniella chlamydospora (old name of Phaeoacremonium chlamidosporum), Faeoacremonium aleofilum and / or Botryosphaeria obtusa; Elsinoe spp. in pigeons (E. pyri) and soft fruits (E. veneta: anthracnose) and also vines (E. ampelina: anthracnose); Entyloma oryzae (leaf coal) in rice; Epicoccum spp. (black ear) in wheat; Graminis spp. (powdery mildew) on sugar beet (E. betae), vegetables (for example, E. pisi), such as cucumber species (for example, E. cichoracearum) and cabbage species, such as rapeseed (for example, E. cruciferarum); Eutypa fata (eutypiosis, anamorph: Cytosporina lata, sin .: Libertella blepharis) in fruit trees, vines and many ornamental trees; Exserohilum (sin .: Helminthosporium) spp. in corn (for example, E. turcicum); Fusarium (teleomorph: Gibberella) spp. (wilting disease, root rot and stem) in various plants, such as, for example, F. graminearum or F. culmorum (root rot and fusariosis) in cereals (for example, wheat or barley), F. oxysporum in tomato, F. solani in soy and F. verticillioides in corn; Gaeumannomyces graminis (disease of the black foot of cereals) in cereals (for example, wheat or barley) and maize; Gibberella spp. in cereals (for example, G. zeae) and rice (for example, G. fujikuroi: fusariose); Glomerella cingulata in vines, pomoids and other plants and G. gossypii in cotton; various phytopathogenic agents that cause stains on rice grains; Guignardia bidwellii (black rot) on vines; Gymnosporangium spp. in rosettes and juniper, for example, G. sabinae (pear rust) in pears; Helminthosporium spp. (sin .: Drechslera, teleomorph: Cochliobolus) in corn, cereals and rice; Hemileia spp., For example, H. vastatrix (coffee leaf rust); Isariopsis clavispora (sin .: Cladosporium vitis) on vines; Macrophomina phasolin (syn .: phaseoli) (root / stem rot) in soybeans and cotton; Microdochium (sin .: Fusarium) nivale (fusariosis) in cereals (wheat or barley); Diffuse microsphaera (powdery mildew) in soybean; Monilinia spp., For example, M. laxa M. fructicola and M. fructigena (rust on the flower and branches) in stone fruit and other rosettes; Mycosphaerella spp. in cereals, bananas, soft fruits and peanuts, such as M. gramnicola (anamorph: Septoria tritici, Septoria leaf spot) in wheat or M. fijiensis (black Sigatoka disease) in bananas; Peronospora spp. (downy mildew), cabbage (for example, p. P. brassicae), rapeseed (for example, P. parasitica), bulbous plants (for example, P. destructor), tobacco (P. tabacina) and soy (for example, P manshurica); Phakopsora pachyrhizi and P. meibomiae (soybean rust) in soybean; Phialophora spp. for example, on vines (for example, P. tracheiphila and P. tetraspora) and soy (for example, P. gregata: stem disease); Phoma lingam (root and stem rot) in rapeseed and cabbage and P. betae (leaf spot) in beet; Phomopsis spp. in sunflowers, vines (for example, P. vitícola: European scoriosis) and soy (for example, stem cancer / stem burning: P. phaseoli, teleomorph: Diaporthe phaseolorum); Physoderma maydis (brown spot) in corn; Phytophthora spp. (wilting disease, root rot, leaf, stem and fruit) in various plants, such as in pepper and cucumber species (for example, P. capsici), soy (for example, P. megasperma, sin .: P. soybean), potato and tomato (for example, mildew by P. infestans.) and deciduous trees (for example, sudden death of the oak by P. ramorum) ', Plasmodiophora brassicae (cabbage colt disease) in cabbage, rapeseed, turnip and other plants; Plasmopara spp., For example, from P. vitícola (downy mildew) on vines and P. halstedii on sunflowers; Podosphaera spp. (powdery mildew) in rosacea, hops, pome and soft fruit, for example, P. leucotricha in apple; Polymyxa spp., For example, in cereals, such as barley and wheat (P. graminis) and beet (P. betae) and viral diseases transmitted in this way; Pseudocercosporella herpotrichoides (crazy bed, teleomorph: Tapesia yallundae) in cereals, for example, wheat or barley; Pseudoperonospora (downy mildew) in various plants, for example, P. cubensis in cucumber species or P. humili in hops; Pseudopezicula tracheiphila (angular leaf spot, anamorph Phialophora) on vines; Puccinia spp. (rust disease) in various plants, for example, P. triticina (brown rust of wheat), P. striiformis (yellow rust). P. hordei (brown rust), P. graminis (black rust) or P. recondita (brown rye rust) in cereals, such as, for example, wheat, barley or rye. P. kuehnii in sugar cane and, for example, asparagus (for example, P. asparagi); Pyrenophora (anamorph: Drechslera) tritici-repentis (speckled leaf spot) in wheat or P. teres (reticular spot) in barley; Pyricularia spp., For example, P. oryzae (teleomorph: Magnaporthe grise, pyriculariosis) in rice and P. grisea in grass and cereals; Pythium spp (seedling wilt disease) on grass, rice, corn, wheat, cotton, rapeseed, sunflower, beet, vegetables and other plants (for example, P. ultimum or P. aphanidermatum); Ramularia spp., For example, R. collo-cygni (leaf and grass spot / physiological leaf spot by Ramularia) in barley and R. beticola in beet; Rhizoctonia spp. on cotton, rice, potatoes, grass, corn, rapeseed, potatoes, sugar beet, vegetables and on various other plants, for example R. solani (root and stem rot) in soybeans, R. solani (rhizoctonia) in rice or R cerealis (crazy corn) in wheat or barley; Rhizopus stolonifer (soft rot) in strawberries, carrots, cabbage, vines and tomatoes; Rhynchosporium secalis (leaf spot) in barley, rye and triticale; Sarocladium oryzae and S. attenuatum (sheath rot) in rice; Sclerotinia spp. (white or stem rot) in horticultural and arable crops, such as rape, sunflower (for example, Sclerotinia sclerotiorum) and soy (for example, S. rolfsii), Septoria spp. in various plants, for example, S. glycines S. (leaf spot) in soy, S. tritici (leaf spot by Septoria) in wheat and S. (sin .: Stagonospora) nodorum (leaf spot and in glumas) in cereals; Uncinula sin .: graminis) necator (powdery mildew, anamorph: Oidium tuckeri) on vines; Setospaeria spp. (leaf spot) in corn (for example, S. turcicum, sin .: Helminthosporium turcicum) and grass; Sphacelotheca spp. (die) in corn, (for example, S. reiliana: grain die), millet and sugar cane; Sphaerotheca fuliginea (powdery mildew) in cucumber species; Underground spongospora (powdery mange) in the potato and the viral diseases transmitted in this way; Stagonospora spp. in cereals, for example, S. nodorum (leaf spot and glume spot, teleomorph: Leptosphaeria [sin .: Phaeosphaeria] nodorum) in wheat; Synchytrium endobioticum, potato (black wart from potato); Taphrina spp., For example, T. deformans (leaf wrapping disease) in peach trees and T. pruni (leprosy) in plums; Thielaviopsis spp. (black root rot) in tobacco, pome, vegetables, soybeans and cotton, for example, T. basicola (sin .: Chalara elegans) ', Tilletia spp (fungus) in cereals, such as, T. tritici (sin. : T. caries, caries) and controversial T. (fungus) in wheat; Typhula incarnata ('gray snow mold') in barley or wheat; Urocystis spp., For example, U. occulta (charcoal) in rye; Uromyces spp. (rust) in vegetables, such as beans (for example, U. appendiculatus, sin .: U. phaseoll) and sugar beet (for example, U. betae); Ustilago spp. (dies) in cereals (for example, U. nuda and U. avaenae), corn (for example, U. maydis: corn dies) and sugar cane; Venturia spp. (stoned) in apples (for example, V. inaequalis) and pears and Verticillium spp. (wilting of leaves and sprouts) in various plants, such as fruit trees and ornamental trees, vines, soft fruits, vegetable and arable crops, such as V. dahliae in strawberries, rapeseed, potatoes and tomatoes.
[219] Greater preference is given to the following soybean diseases: Cercospora kikuchii, Cercospora sojina; Colletotrichum gloeosporoides dematium var. truncatum; Corynespora casiicola; Diaporthe phaseolorum; Microsphaera diffusa; Peronospora manshurica; Phakopsora, species, for example Phakopsora pachyrhizi and Phakopsora meibomiae (soybean rust); Phytophthora megasperma; Phialophora gregata; Rhizoctonia solanf, Sclerotinia sclerotiorum; Septoria spp., For example Septoria glycines, Thielaviopsis basicola.
[220] The present invention is also directed to the use of the combinations according to the invention for the treatment of soybean diseases. Plant growth regulation
[221] In some cases, the inventive compounds may, at certain concentrations or rates of application, also be used as herbicides, phytotoxicity protectors, growth regulators or agents to improve plant properties, or as microbicides, for example, as fungicides, antimycotics, bactericides, viricides (including compositions against viroids) or as compositions against MLO (Mycoplasma Type Organisms) and RLO (Rickettsia Type Organisms). If applicable, they can also be used as intermediates or precursors for the synthesis of other active ingredients.
[222] The active ingredients of the invention intervene in the metabolism of plants and, as such, can also be used as growth regulators.
[223] Growth regulators can have a variety of effects on plants. The effect of the substances depends essentially on the moment of application in relation to the stage of development of the plant and also on the amount of active principle applied to the plants or in their environment, and the type of application. The growth regulators should have a certain effect on the crop plants as desired in each case.
[224] Plant growth regulating compounds may be used, for example, to inhibit plant growth. This inhibition of growth is of economic interest, as, for example, in the case of grasses, as this way it is possible to reduce the frequency of mowing in ornamental gardens, parks and sports facilities, roadside, airports, or in fruit crops . It is also important to inhibit the growth of herbaceous and woody plants on roadsides and near ducts or overhead cables, or in general in areas where vigorous plant growth is undesirable.
[225] The use of growth regulators is also important to inhibit the longitudinal growth of cereals. This reduces or completely eliminates the risk of bedding from crops before harvest. In addition, cereal growth regulators can reinforce the stalk, which also contradicts the bedding. The use of growth regulators to shorten and strengthen the stalks allows the use of larger volumes of fertilizer to increase yield without any risk of bedding in the grain harvest.
[226] In many crop plants, the inhibition of vegetative growth allows for dense planting and, as such, it is possible to achieve higher yields for a given soil surface. Another advantage of smaller plants obtained in this way, is that the harvest is easier to grow and harvest.
[227] Inhibiting the plant's vegetative growth can also lead to improved productivity, since nutrients and assimilates are more beneficial for the formation of flowers and fruits than for the vegetative parts of plants.
[228] Growth regulators can often be used to promote vegetative growth. This is of great benefit when harvesting the vegetative parts of the plant. However, the stimulation of vegetative growth can also promote generative growth, with the formation of more assimilates, resulting in more or greater fruits.
[229] In some cases, increased yield can be achieved by manipulating the plant's metabolism without any detectable change in vegetative growth. In addition, growth regulators can be used to change the composition of plants, which in turn can result in an improvement in the quality of harvested products. For example, it is possible to increase the sugar content in sugar beet, sugar cane, pineapples and citrus fruits, or to increase the protein content in soy or cereals. It is also possible, for example, to use growth regulators to inhibit the degradation of desirable components, for example, sugar in beet or sugar cane, before or after harvest. It is also possible to positively influence the production or elimination of secondary plant components. An example is the stimulation of the latex flow in the rubber trees.
[230] Under the influence of growth regulators, parthenocarpic fruits can be formed. In addition, it is possible to influence the sex of the flowers. It is also possible to produce sterile pollen, which is of great importance in the creation and production of hybrid seeds.
[231] The use of growth regulators can control the branching of plants. On the one hand, by breaking the apical dominance, it is possible to promote the development of lateral shoots - which can be highly desirable especially in the cultivation of ornamental plants - in combination with a growth inhibition. On the other hand, it is also possible to inhibit the growth of lateral shoots. This effect is of particular interest, for example, in the cultivation of tobacco or tomatoes.
[232] Under the influence of growth regulators, the amount of leaves on plants can be controlled so that their defoliation occurs at the desired time. This defoliation plays an important role in the mechanical harvest of cotton, but it is also of interest to facilitate the harvest of other crops, for example, viticulture. Defoliation can also be performed to reduce plant transpiration before transplanting.
[233] Growth regulators can also be used to regulate fruit dehiscence. On the one hand, it is possible to avoid dehiscence of premature fruit. On the other hand, it is also possible to promote dehiscence of the fruits or even the abortion of flowers in order to obtain a desired mass (thinning) and eliminate alternation. Alternation means the characteristic of some species of fruit, which for endogenous reasons have very different yields from year to year. Finally, it is possible to use growth regulators at the time of harvest in order to reduce the force required to separate the fruits and allow mechanical harvesting or facilitate manual harvesting.
[234] Growth regulators can also be used to achieve faster or delayed ripening of the harvested material, before or after harvest. This is particularly advantageous, as it allows an ideal adjustment to market requirements. In addition, in some cases, growth regulators can improve the color of the fruit. In addition, growth regulators can also be used to concentrate maturation over a given period of time. This creates the necessary conditions for a complete harvest, manual or mechanical, in a single operation, for example, in the case of tobacco, tomatoes or coffee.
[235] With the use of growth regulators, it is also possible to influence the rest of the seeds or buds of plants, so that plants such as pineapple, or ornamental plants in nurseries, for example, germinate, sprout or flower at a height where they are not normally inclined to do so. In areas where there is a risk of frost, it may be desirable to delay the flowering or germination of seeds with the help of growth regulators, in order to avoid the damage resulting from delayed frosts.
[236] Finally, growth regulators can induce plant resistance to frost, drought or high soil salinity. This allows for the cultivation of plants in regions that are normally unsuitable for this purpose. Resistance induction / Phytosanitary and other effects
[237] The active compounds according to the invention also have a potent plant strengthening effect. Therefore, they can be used to mobilize the plant's defenses against attack by unwanted microorganisms.
[238] Plant-strengthening substances (resistance induction) should be understood in the present context as those substances capable of stimulating the plant's defense system in such a way that, when subsequently inoculated with unwanted microorganisms, the treated plants exhibit a high degree of resistance to these microorganisms.
[239] The active compounds according to the invention are also suitable for increasing crop yields. In addition, they have reduced toxicity and are well tolerated by plants.
[240] Furthermore, in the context of the present invention, the effects on plant physiology are as follows:
[241] tolerance to abiotic stress, comprising temperature tolerance, drought tolerance and recovery after drought exposure, water use efficiency (corresponding to a reduction in water consumption), flood tolerance, ozone tolerance and UV rays, tolerance to chemicals such as heavy metals, salts, pesticides (phytotoxicity protector), etc .;
[242] tolerance to biotic stress, including increased resistance to fungi, nematodes, viruses and bacteria. In the context of the present invention, tolerance to biotic stress preferably comprises increased resistance against fungi and increased resistance against nematodes.
[243] greater plant vigor, comprising plant health / plant quality and seed vigor, reduced planting risk, improved appearance, improved recovery, improved greening effect and improved photosynthetic efficiency;
[244] effects on plant hormones and / or functional enzymes;
[245] effects on growth regulators (promoters), including early germination, better emergence, more developed root system and / or improved root growth, increased tillering capacity, more productive tillers, early flowering, height increase and / or plant biomass, shortening of the stems, improvement in shoot growth, number of grains / ear, number of ears / m2, number of stoles and / or number of flowers, higher harvest rate, larger leaves, less dead leaves at the base , improved phyllotaxis, early ripening / early finishing of the fruit, homogeneous ripening, prolonged grain filling, better finishing of the fruit, larger fruit / vegetable size, resistance to germination and reduced litter;
[246] higher yield, based on total biomass per hectare, yield per hectare, grain / fruit weight, seed size and / or weight per hectolitre, as well as better product quality, comprising:
[247] better processability due to size distribution (grain, fruit, etc.), homogeneous ripening, grain moisture, better grinding, better vinification, better brewing, greater juice yield, ease of harvest, digestibility, index of sedimentation, fall time, pod stability, storage stability, improvement in fiber length / strength / uniformity, improvement in the quality of milk and / or meat from animals fed with silage, adaptation for cooking and frying;
[248] including easier marketing due to improved fruit / grain quality, size distribution (grains, fruit, etc.), increased shelf life / shelf life, firmness / softness, flavor (aroma, texture, etc. .), class (size, shape, number of berries, etc.), number of berries / fruits per bunch, crunchy texture, freshness, covering with wax, frequency of physiological disorders, color, etc .;
[249] further comprising increasing the desired components such as, for example, protein content, fatty acids, oil content, oil quality, amino acid composition, sugar content, acidity content (f), sugar / ratio acid (Brix), polyphenols, starch content, nutritional quality, gluten content / index, energy content, flavor, etc .;
[250] and further comprising the reduction of unwanted components such as, for example, less mycotoxins, less aflatoxins, geosmin level, phenolic flavors, lactase, polyphenols oxidases and peroxidases, nitrate content, etc .;
[251] sustainable agriculture, comprising efficiency in the use of nutrients, especially efficiency in the use of nitrogen (N), efficiency in the use of phosphorus (P), efficiency in the use of water, better transpiration, respiration and / or rate of assimilation of CO2, better nodulation, improved Ca metabolism, etc .;
[252] delayed senescence, comprising improvement in plant physiology, which is manifested, for example, by a phase of filling the grain of longer duration leading to a higher yield, more prolonged coloring of the green leaves of the plant and, therefore, comprising color ( water content, dryness, etc. In this sense, in the context of the present invention, it was found that the specific inventive application of the combination of active compounds makes it possible to prolong the duration of the green leaf zone, delaying the maturation (senescence) of the plant. The main advantage for the farmer is a prolonged grain filling phase, leading to greater yield. There is also the advantage for the farmer of greater flexibility at harvest time.
[253] Here, "sedimentation index" is a measure of protein quality and describes, according to Zeleny (Zeleny value), the degree of sedimentation of flour suspended in a lactic acid solution during a standard time interval. This is taken as a measure of the quality of cooking. The expansion of the gluten fraction of the flour in the lactic acid solution affects the settling speed of a flour suspension. Both a higher content and a better quality of gluten result in slower sedimentation and higher Zeleny test values. The sedimentation index of the flour depends on the composition of the wheat protein and is correlated mainly with the protein content, the wheat hardness and the volume of artisan breads. A strong correlation between bread volume and Zeleny sedimentation volume compared to SDS sedimentation volume may be due to the protein content, which influences Zeleny volume and value (Czec J. Food Sei. Vol. 21, No. 3: 91-96, 2000).
[254] In addition, the "fall time" as referred to here is a measure of the cooking quality of cereals, especially wheat. The drop time test indicates that damage to the shoots may have occurred. This means that changes in physical properties have already taken place in the wheat seed starch. Here, the drop time instrument analyzes viscosity by measuring the resistance of a dough and water to a falling plunger. The time (in seconds) for this to happen is known as the down time. The fall time results are recorded as an index of the enzymatic activity of a sample of wheat or flour and are expressed in seconds. A high fall time (for example, greater than 300 seconds) indicates minimal enzymatic activity and good quality of wheat or flour. A low fall time (for example, less than 250 seconds) indicates substantial enzymatic activity and wheat or flour from damaged sprouts.
[255] The term 'more developed root system' / 'improved root growth' refers to a longer root system, deeper root growth, faster root growth, greater dry / fresh root weight, greater root volume, greater root surface area, greater root diameter, greater root stability, more root branching, greater number of root hairs, and / or more root ends, and can be measured through architectural analysis from scratch by suitable methodologies and image analysis programs (for example WinRhizo).
[256] The term "efficiency of water use by culture" refers, from a technical point of view, to the mass of agricultural products per unit of water consumed and, from an economic point of view, to the value of the product (s) produced per unit volume of water consumed, and can be expressed, for example, in terms of yield per ha, plant biomass, mass of a thousand seeds and the number of ears per m2
[257] The term "nitrogen utilization efficiency" technically refers to the mass of agricultural products produced per unit of nitrogen consumed and economically to the value of the product (s) produced per unit of nitrogen consumed, reflecting the absorption and utilization efficiency .
[258] Improvements in greening / color and photosynthetic efficiency, as well as delay in senescence, can be assessed by well-known techniques, such as a HandyPea (Hansatech) system. Fv / Fm is a widely used parameter, which indicates the maximum quantum efficiency of photosystem II (FSII). This parameter is considered a selective indication of the photosynthetic performance of the plants, with healthy samples normally reaching a maximum Fv / Fm value of approximately 0.85. Lower values are observed if the sample has been exposed to some type of biotic or abiotic stress factor that reduced its photochemical energy absorption capacity in the FSII. Fv / Fm is presented as the ratio of the variable fluorescence (Fv) to the maximum fluorescence value (Fm). The performance index is essentially an indicator of the sample's vitality. (See, for example Advanced Techniques in Soil Microbiology, 2007, 11, 319-341; Applied Soil Ecology, 2000, 15, 169-182.)
[259] Improvements in greening / color and photosynthetic efficiency, as well as delay in senescence, can also be assessed by measuring the liquid photosynthetic rate (Pn), measuring the chlorophyll content, for example, by the pigment extraction method Ziegler and Ehle, measurement of photochemical efficiency (Fv / Fm ratio), determination of shoot growth and final root and / or crown biomass, determination of tiller density, as well as root mortality.
[260] Within the scope of the present invention, preference is given to improving the effects on the physiology of plants selected from the group of: improved root growth / more developed root system, improvement in greening, greater water use efficiency (corresponding to consumption reduced water), greater efficiency in the use of nutrients, especially comprising greater efficiency in the use of nitrogen (N), delayed senescence and greater yield.
[261] With regard to yield improvement, preference is given to an improvement in the sedimentation index and fall time, as well as an improvement in the protein and sugar content - especially in plants selected from the cereal group (preferably wheat).
[262] Preferably, the new use of the fungicidal compositions of the present invention relates to a combined use of a) preventive and / or curative control of pathogenic and / or nematode fungi, with or without resistance management and b) at least one between improved root growth, improved greening, greater water use efficiency, delayed senescence and increased yield. In group b), the improvement of the root system, water use efficiency and N use are particularly preferred Seed treatment
[263] The invention further comprises a method of treating seeds.
[264] The invention also relates to seeds that have been treated by one of the methods described above. The seeds of the invention are used in methods of protecting seeds against unwanted microorganisms. In one of these methods, seeds treated with at least one active ingredient of the invention are used.
[265] The active ingredients or compositions of the invention are also suitable for seed treatment. A large part of the damage caused to crops by harmful organisms is triggered by the infection of seeds during storage or after sowing, and also during and after germination of the plant. This stage is particularly important, as the roots and shoots of the growing plant are particularly sensitive, and even minor damage can result in the death of the plant. As such, there is a great interest in protecting the seed and the germinating plant with suitable compositions.
[266] The control of phytopathogenic fungi by treating plant seeds has been known for a long time and has been the subject of constant improvements. However, seed treatment involves a number of problems that cannot always be satisfactorily solved. For example, it is desirable to develop methods of protecting the germinating seed and plant that dispense, or at least significantly reduce, the additional use of plant protection compositions after planting or after plant emergence. It is also desirable to optimize the amount of active ingredient used, in order to offer the best possible protection to the seed and the germinating plant against attack by phytopathogenic fungi, without damaging the plant itself with the active ingredient used. In particular, seed treatment methods must also take into account the intrinsic fungicidal properties of transgenic plants, in order to ensure optimum protection of the seed and the germinating plant with a minimum of cost in plant protection compositions.
[267] The present invention, therefore, also relates to a method of protecting seeds and germinating plants against attack by phytopathogenic fungi, by treating the seeds with an inventive composition. Likewise, the invention relates to the use of inventive compositions in the treatment of seeds to protect the seed and the germinating plant against phytopathogenic fungi. The invention also relates to seeds that have been treated with an inventive composition for protection against phytopathogenic fungi.
[268] The control of phytopathogenic fungi that damage post-emergence plants is mainly accomplished by treating soil and plant parts at ground level with plant protection compositions. Bearing in mind the concern with a possible impact of plant protection compositions on the environment and on the health of humans and animals, efforts have been made to reduce the amount of active principles applied.
[269] One of the advantages of the present invention is due to the fact that, due to the specific systemic properties of the compositions according to the invention, the treatment of the seeds with these compositions not only protect the seed itself against phytopathogenic fungi, but also post-emergence plants. In this way, immediate treatment of the crop at the moment of sowing, or immediately afterwards, can be dispensed with.
[270] It is also considered advantageous that the active ingredients or compositions of the invention can be used especially with transgenic seeds, in which the plant that grows from this seed is capable of expressing a protein that acts against infestations. When treating seeds with the active ingredients or compositions of the invention, certain infestations can be controlled by simply expressing a protein, for example, an insecticidal protein. Surprisingly, an additional synergistic effect can be seen here, which further increases the effectiveness of protection against attack by infestations.
[271] The compositions according to the invention are suitable for protecting the seeds of any variety of plant used in agriculture, in greenhouses, in forests or in horticulture or viticulture. In particular, these are cereal seeds (such as wheat, barley, rye, triticale, sorghum / millet and oats), corn, cotton, soybeans, rice, potatoes, sunflower, beans, coffee, beets (for example, sugar beets and fodder beets), peanuts, rapeseed, poppy, olives, coconut, cocoa, sugar cane, tobacco, vegetables (such as tomatoes, cucumbers, onions and lettuce), grass and ornamental plants (see also below). The treatment of cereal seeds (such as wheat, barley, rye, triticale and oats), corn and rice is of special importance.
[272] As also described below, the treatment of transgenic seeds with the active ingredients or compositions of the invention is of special importance. This concerns plant seeds that carry at least one heterologous gene that controls the expression of a polypeptide or protein with insecticidal properties. The heterologous gene in transgenic seeds may originate from, for example, microorganisms of the species Bacillus, Rhizobium, Pseudomonas, Serratia, Trichoderma, Clavibacter, Glomus or Gliocladium. This heterologous gene is preferably from Bacillus sp., In which case the gene product is effective against the European corn borer variant and / or against the chromomelid of the corn root system. The heterologous gene is preferably from Bacillus thurínglensls.
[273] In the context of the present invention, the composition of the invention is applied to the seed alone or in a suitable formulation. Preferably, the seed to be treated is in a sufficiently stable state to not be damaged during treatment. In general, the seed can be treated at any time between harvest and sowing. Usually, the seed used is separated from the plant and released from the cores, shells, stems, coverings, coat or pulp of the fruits. Thus, it is possible to use, for example, seeds that have been harvested, cleaned and dried to a moisture content of less than 15% by weight. Alternatively, it is also possible to use seeds that, after drying, have been treated, for example, with water, and dried again.
[274] When treating seeds, care should generally be taken to ensure that the amount of composition according to the invention applied to the seed, and / or the amount of other additives, is chosen so as not to affect the germination of the seeds. seeds, or not to damage the plant that will result from them. This must be taken into account especially in the case of active ingredients that may have phytotoxic effects at certain rates of application.
[275] The compositions according to the invention can be applied directly, that is, without including other components and without previous dilution. In general, it is preferable to apply the compositions to the seeds in the form of a suitable formulation. Suitable formulations and methods for seed treatment are known to those skilled in the art and are described, for example, in the following documents: US 4,272,417, US 4,245,432, US 4,808,430, US 5 876 739, US 2003/0176428 A1, WO 2002/080675 and WO 2002/028186.
[276] The active ingredients that can be used according to the invention can be converted into the usual seed treatment formulations, such as solutions, emulsions, suspensions, powders, foams, pastes or other seed treatment compositions, as well as formulations ultra low volume.
[277] These formulations are prepared in a known way, by mixing the active ingredients with the usual additives such as fillers, solvents or diluents, dyes, wetting agents, dispersants, emulsifiers, defoamers, preservatives, secondary thickeners, adherents, gibberellins and also water.
[278] Suitable dyes that may be present in seed treatment formulations used according to the invention include all the usual dyes for such purposes. Both water-soluble pigments and water-soluble dyes can be used. Examples that can be mentioned include the dyes known under the designations Rhodamine B, C.I. Red Pigment 112 and C.I. Red Solvent 1.
[279] Useful wetting agents that may be present in seed treatment formulations used according to the invention include all substances that promote wetting and that are conventionally used in the formulation of active agrochemicals. Preference is given to the use of alkylnaphthalene sulfonates, such as diisopropyl- or diisobutylnaphthalene sulfonates.
[280] Suitable dispersants and / or emulsifiers that may be present in seed treatment formulations used according to the invention include all nonionic, anionic and cationic dispersants used conventionally in the formulation of active agrochemicals. Preferably, nonionic or anionic dispersants, or mixtures of nonionic or anionic dispersants are used. Suitable non-ionic dispersants are ethylene oxide-propylene oxide block polymers, alkylphenol polyglycolic ethers and tristyrylphenol polyglycolic ethers and their phosphate or sulfate derivatives. Especially suitable anionic dispersants are lignosulfonates, polyacrylic acid salts and arylsulfonate-formaldehyde condensates.
[281] Defoamers that may be present in seed treatment formulations used according to the invention include all foam-inhibiting compounds that are common in the formulation of active agrochemicals. Preference is given to the use of silicone defoamers and magnesium stearate.
[282] The preservatives that can be present in the seed treatment formulations used according to the invention are all substances used for the same purposes in agrochemical compositions. For example, dichlorophene and benziform hemiformal may be mentioned.
[283] The secondary thickeners that may be present in the seed treatment formulations used according to the invention are all substances that can be used for such purposes in agrochemical compositions. Preferred examples include cellulose derivatives, acrylic acid derivatives, xanthan gum, modified clays and finely divided silica.
[284] Suitable adherent agents that may be present in seed treatment formulations used in accordance with the invention include all of the usual binders used in seed treatment products. Polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and tylose can be mentioned as preferred examples.
[285] The gibberellins which may be present in the seed treatment formulations used according to the invention are preferably gibberellins A1, A3 (= gibberellic acid), A4 and A7; special preference is given to gibberellic acid. Gibberellins are well known (see R. Wegler “Chemie der Pflanzenschutz- und SchadlingsbekampfungsmitteF [Chemistry of Crop Protection and Pesticides], Vol. 2, Springer Verlag, 1970, pp. 401-412).
[286] Seed treatment formulations that can be used according to the invention can be used directly or after previous dilution with water, for the treatment of a wide range of different seeds, including the seeds of transgenic plants. In this case, synergistic effects may also occur in the interaction with the substances formed by expression.
[287] For seed treatment with the seed treatment formulations used in accordance with the invention, or with the preparations obtained from those by adding water, all mixing equipment normally used for seed treatment purposes is useful . Concretely, the procedure adopted during the treatment consists of introducing the seeds in a mixer, adding the specific amount of seed treatment formulation required alone or previously diluted with water, and mixing until the formulation is evenly distributed over the seed. Optionally, it is followed by a drying operation. Mycotoxins
[288] In addition, the treatment according to the invention can reduce the mycotoxin content in the harvested material and in the food prepared from it. Especially, but not exclusively, mycotoxins include: deoxynivalenol (DON), nivalenol, 15-Ac-DON, 3-Ac-DON, toxins T2 and HT2, fumonisins, zearalenone, moniliformine, fusarin, diaceotoxiscirpenol (DAS), beauvericin, eniatin, fusaroproliferin, fusarenol, ochratoxins, patulin, ergot alkaloids and aflatoxins, which are caused for example by the following fungi: Fusarium spec., such as F. acuminatum, F. asiaticum, F. avenaceum, F. crookwellense, F. culmorum , F. graminearum (Gibberella zeae), F. equiseti, F. fujikoroi, F. musarum, F. oxysporum, F. proliferatum, F. poae, F. pseudograminearum, F. sambuciem um, F. scirpi, F. semitectum, F. solani, F. sporotrichoides, F. langsethiae, F. subglutinans, F. tricinctum, F. verticillioides etc., and also by Aspergillus species, such as A. flavus, A. parasiticus, A. nomi us, A. och raceus, A. clavatus, A. terreus, A. versicolor, Penicillium spec., such as P. verrucosum, P. viridicatum, P. citriem um, P. expansum, P. cl aviforme, P. roqueforti, Claviceps species, such as C. purpurea, C. fusiformis, C. paspali, C. africana, Stachybotrys species and others. Material Protection
[289] The active ingredients or compositions of the invention can also be used in the protection of materials, to protect industrial materials from attack and destruction by unwanted microorganisms, for example fungi and insects.
[290] In addition, the inventive compounds can be used as anti-fouling compositions, either alone or in combinations with other active ingredients.
[291] Industrial materials in the current context are inanimate materials that have been prepared for use in industry. For example, industrial materials that have to be protected by inventive active ingredients against alteration or destruction by microbes can be adhesives, glues, paper, wallpaper and card / cardboard, textiles, carpets, leather, wood, fibers and fabrics, paints and plastic articles, cooling lubricants and other materials that can be infected or destroyed by microorganisms. Parts of factories and buildings, for example, water cooling circuits, cooling and heating systems, and ventilation and air conditioning units, which can be harmed by the proliferation of microorganisms, are also part of the materials that need protection. Industrial materials within the scope of the present invention preferably include adhesives, sealants, paper and board, leather, wood, paints, cooling lubricants and heat transfer fluids, more preferably wood.
[292] The active ingredients or compositions of the invention can prevent adverse effects, such as decay, decomposition, discoloration, or mold formation.
[293] In the case of wood treatment, the compounds / compositions according to the invention can also be used against fungal diseases that can grow on the surface or interior of the wood. The term "wood" means all types of wood and all types of wood products intended for construction, for example, solid wood, high density wood, laminated and plywood. The method for treating the wood according to the invention consists mainly of contacting it with one or more compounds according to the invention, or a composition according to the invention; this includes, for example, direct application, spraying, dipping, injection or any other suitable means.
[294] In addition, inventive compounds can be used to protect objects that come into contact with salt or brackish water, especially hulls, screens, nets, buildings, anchorages and signaling systems, against vegetative growth.
[295] The method according to the invention can also be used to protect stored goods. Stored goods are understood to mean natural substances, of vegetable or animal origin, or their processed products of natural origin, for which long-term protection is desired. Stored goods of plant origin, such as plants or parts of plants, for example, stems, leaves, tubers, seeds, fruits or grains, can be protected in the freshly harvested state or after processing by (pre) drying, moistening, fragmentation, grinding, pressing or roasting. Stored goods also include wood, either in unprocessed form, such as construction wood, electricity poles and barriers, or in the form of finished items, such as furniture. Stored goods of animal origin consist of, for example, furs, leather, fur with fur, and fur. The active principles of the invention can prevent adverse effects, such as rotting, decomposition, discoloration or mold formation.
[296] Microorganisms capable of degrading or altering industrial materials include, for example, bacteria, fungi, yeasts, algae and slime organisms. The active ingredients of the invention preferably act against fungi, especially molds, wood decolorizing fungi and wood destroying fungi (Ascomycetes, Basidíomycetes, Deuteromycetes and Zygomycetes), and against slime and algae organisms. Examples include organisms of the following genera: Alternaria, such as Alternaria tenuis', Aspergillus, such as Aspergillus niger, Chaetomium, such as Chaetomium globosunr, Coniophora, such as Coniophora puetana ', Lentinus, such as Lentinus tigrinus', Penicillium, tal such as Penicillium glaucunr, Polyporus, such as Polyporus versicolor, Aureobasidium, such as Aureobasidium pullulans', Sclerophoma, such as Sclerophoma pityophila ', Trichoderma, such as Trichoderma viride', Ophiostoma spp., Ceratocystis spp., Spic. , Trichurus spp., Coriolus spp., Gloeophyllum spp., Pleurotus spp., Poria spp., Serpula spp. and Tyromyces spp., Cladosporium spp., Paecilomyces spp. Mucor spp., Escherichia, such as Escherichia colr, Pseudomonas, such as Pseudomonas aeruginosa, Staphylococcus, such as Staphylococcus aureus, Candida spp. And Saccharomyces spp., Such as Saccharomyces cerevisae. Antimycotic activity
[297] In addition, the active principles of the invention also have excellent antimycotic activity, namely a very broad spectrum of antimycotic activity, especially against dermatophytes and yeasts, molds and diphasic fungi (for example, against Candida species such as C. albicans, C. glabrata), and Epidermophyton floccosum, Aspergillus species, such as A. niger and A. fumigatus, Trichophyton species, such as T. mentagrophytes, Microsporon species, such as M. canis and M. audouinii. The present list of fungi is for illustrative purposes only and does not restrict the covered mycotic spectrum in any way.
[298] The active ingredients of the invention can therefore be used in medical and non-medical applications. GMO
[299] As previously mentioned, it is possible to treat all plants and their parts according to the invention. In a preferred embodiment, species of wild plants and cultivars are treated, or those obtained by conventional methods of biological reproduction, such as crossing or fusion of protoplasts, and also their parts. In a preferred embodiment, transgenic plants and cultivars obtained by genetic engineering methods are treated, possibly in combination with conventional methods (Genetically Modified Organisms), and their parts. The terms "parts" or "parts of plants", or "parts of the plant" have been explained above. More preferably, plants of commercially available or in use cultivars are treated according to the invention. Cultivars are plants that have new characteristics ("traits") and that were obtained by conventional reproduction, mutagenesis or by recombinant DNA techniques. They can be cultivars, varieties, bio- or genotypes.
[300] The treatment method according to the invention is used in the treatment of genetically modified organisms (GMOs), for example, plants or seeds. Genetically modified plants (or transgenic plants) are plants with a heterologous gene integrated into the genome. The term "heterologous gene" essentially means a gene that has been obtained or "assembled" outside the plant and which, after being introduced into the nuclear, chloroplastic or mitochondrial genome, gives rise to a new transformed plant, with improved agronomic or other properties either by the expression of a protein or polypeptide of interest, or by the lack of regulation or silencing of other gene (s) present in the plant (using, for example, antisense technology, co-suppression technology, RNA interference technology (RNAi), or micro technology RNA (miRNA) A heterologous gene located in the genome is also called a transgene A transgene, which is defined by its specific location in the plant's genome, is called a transformation or transgenic event.
[301] Depending on the species of plant or cultivar, the location and growing conditions (soil, climate, vegetation period, nutrition), the treatment according to the invention can also give rise to superadditive ("synergistic") effects. Thus, it is possible to achieve, for example, reduced application rates and / or broadening of the activity spectrum, and / or increased activity of the compositions and active compounds according to the invention, better plant growth, greater tolerance to high temperatures or low, greater tolerance to drought or salt content in water or soil, more intense flowering, easier harvesting, accelerated ripening, greater yield of crops, larger fruits, greater plant height, greener leaf, early flowering , better quality and / or greater nutritional value of the harvested products, higher concentration of sugar in the fruits, better storage stability and / or processing capacity of the harvested products, which exceed the expected effects.
[302] At certain application rates, combinations of active compounds according to the invention can also have a strengthening effect on plants. Therefore, they are also suitable for mobilizing the plant's defense system against attack by unwanted microorganisms. This may possibly be one of the reasons for the increased activity of the combinations according to the invention, for example, against fungi. Plant strengthening substances (resistance induction) must be understood, in the present context, those substances or combinations of substances capable of stimulating the defense system of plants in such a way that, when subsequently inoculated with unwanted microorganisms, the treated plants exhibit a high degree of resistance to these microorganisms. In the present case, unwanted microorganisms include fungi, bacteria and phytopathogenic viruses. Thus, the substances according to the invention can be used to protect plants against attack by the aforementioned pathogens for a certain period of time after treatment. The period of protective effects generally extends from 1 to 10 days, preferably 1 to 7 days, after treatment of the plants with the active compounds.
[303] The plants and cultivars preferably treated according to the invention include all plants with genetic material that gives them especially advantageous and useful characteristics (whether obtained by reproduction and / or by biotechnological means).
[304] The plants and cultivars preferably treated according to the invention are resistant against one or more biotic stresses, that is, these plants exhibit an excellent defense against animal and microbial pests, such as nematodes, insects, mites, fungi, bacteria, phytopathogenic viruses and viruses.
[305] Examples of plants resistant to nematodes or insects are described in US Patent Applications 11/765 491, 11/765 494, 10/926 819, 10/782 020, 12/032 479, 10/783 417, 10 / 782 096, 11/657 964, 12/192 904, 11/396 808, 12/166 253, 12/166 239, 12/166 124, 12/166 209, 11/762 886, 12/364 335, 11 / 763 947, 12/252 453, 12/209 354, 12/491 396, 12/497 221, 12/644 632, 12/646 004, 12/701 058, 12/718 059, 12/721 595, 12 / 638 591.
[306] The plants and cultivars that can also be treated according to the invention are those resistant to one or more abiotic stresses. Abiotic stress conditions can include, for example, drought, exposure to cold, exposure to heat, osmotic stress, flooding, increased soil salinity, increased exposure to minerals, exposure to ozone, too much exposure to light, limited availability of nutrients nitrogen, limited availability of phosphate nutrients, avoidance of shade.
[307] Plants and cultivars that can also be treated according to the invention are characterized by a higher yield. A higher yield in these plants may be the result of, for example, improvement in plant physiology, growth and development, such as efficiency in water use, efficiency in water retention, better use of nitrogen, greater assimilation of carbon, better photosynthesis, greater germination efficiency and accelerated maturation. Yield can also be affected by improved plant architecture (under stress and non-stress conditions), including, but not limited to, early flowering, flowering control for hybrid seed production, seedling vigor, plant size, number and distance of nodes, root growth, seed size, fruit size, pod size, number of pods or ears, number of seeds per pod or ear, seed mass, improved seed filling, reduced seed dispersion , reduced pod dehiscence and resistance to bedding. Other yield characteristics include seed composition, such as carbohydrate content, protein content, oil content and composition, nutritional value, reduction to anti-nutritional compounds, improved processability and better storage stability.
[308] The plants that can be treated according to the invention are hybrid plants that already express the characteristic of heterosis or hybrid vigor that generally results in an increase in yield, vigor, health and resistance to biotic and abiotic stress factors. These plants are usually prepared by crossing a pure andro-sterile parental line (the female parent) with another pure androphic parental line (the male parent). Hybrid seed is usually harvested from androestile plants and sold to producers. Andro-sterile plants can sometimes be obtained (for example, in the case of corn) by removing the tassel, that is, by mechanically removing the male reproductive organs (or male flowers) but, more typically, male sterility is the result of genetic determinants of the plant genome. In that case, and especially when the seed is the desired product, the harvest path of hybrid plants is generally useful in ensuring that male fertility in hybrid plants is fully restored. This can be achieved by ensuring that male parents have adequate fertility restoring genes, capable of restoring male fertility in hybrid plants carrying the genetic determinants responsible for male sterility. The genetic determinants of male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) have been described, for example, for the species Brassica (WO 92/05251, WO 95/09910, WO 98/27806, WO 05/002324, WO 06/021972 and US 6 229 072). However, genetic determinants of male sterility can also be found in the nuclear genome. Sterile male plants can also be obtained by plant biotechnology methods such as genetic engineering. An especially useful way of obtaining andro-sterile plants is described in WO 89/10396, in which a ribonuclease, such as barnase, is selectively expressed in tapetum cells of the stamens. Fertility can be restored by the expression, in tapetum cells, of a ribonuclease inhibitor, such as the barstar gene (for example, WO 91/02069).
[309] Plants or cultivars (obtained by methods of plant biotechnology such as genetic engineering) that can be treated according to the invention are tolerant to herbicides, that is, taken tolerant to one or more certain herbicides. These plants can be obtained by genetic transformation, or by selecting plants with a mutation that gives such tolerance to herbicides.
[310] Herbicide resistant plants are, for example, tolerant to glyphosate, that is, made tolerant to the herbicide glyphosate or its salts. Plants can be made tolerant to glyphosate in several ways. For example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylchiquimate-3-phosphate synthase (EPSPS). Examples of EPSPS genes are the AroA gene (CT7 mutant) from the bacterium Salmonalla tifimurium (Science 1983, 221, 370-371), the CP4 gene from the bacterium Agrobacterium sp. (Curr. Topics Plant Fisiol. 1992, 7, 139-145), the genes encoding an EPSPS petunia (Science 1986, 233, 478-481), an EPSPS tomato (J. Biol. Cem. 1988, 263, 4280- 4289), or an Eleusiπa EPSPS (WO 01/66704). It can also be a mutant EPSPS as described in, for example, EP 0837944, WO 00/66746, WO 00/66747 or WO 02/26995. Glyphosate-tolerant plants can also be obtained by expressing a gene encoding the glyphosphate reductase oxide enzyme, as described in US 5,776,760 and US 5,463,175. Glyphosate tolerant plants can also be obtained by expressing a gene encoding a glyphosate-acetyltransferase enzyme as described in, for example, WO 02/036782, WO 03/092360, WO 2005/012515 and WO 2007/024782. Glyphosate-tolerant plants can also be obtained by selecting plants that contain natural mutations of the aforementioned genes, as described in, for example, WO 01/024615 or WO 03/013226. Plants that express EPSPS genes that confer glyphosate tolerance are described, for example, in US Patent Applications 11/517 991, 10/739610, 12/139408, 12/352532, 11/312866, 11/315678, 12/421 292 , 11/400598, 11/651 752, 11/681 285, 11/605824, 12/468205, 11/760570, 11/762 526, 11/769 327, 11/769 255, 11/943 801 or 12/362 774. Plants carrying other genes that also confer glyphosate tolerance, such as the decarboxylase genes, are described, for example, in US Patent Applications 11/588 811, 11/185 342, 12 // 364 724, 11 / 185 560 or 12/423 926.
[311] Other herbicide-resistant plants are, for example, plants that have been made tolerant to herbicides that inhibit the enzyme glutamine synthase, such as bialafos, phosphinothricin or glufosinate. These plants can be obtained by expressing an herbicide detoxifying enzyme or an inhibiting resistant glutamine synthase mutant enzyme as, for example, described in US Patent Application 11/760 602. An efficient detoxifying enzyme is an enzyme encoding a phosphinothricin-acetyltransferase (such as the BAR or PAT protein of Streptomices species). Plants that express an exogenous phosphinothricin-acetyltransferase are described in U.S. Patents 5,561,236; 5,648,477; 5 646 024; 5,273,894; 5 637 489; 5,276,268; 5,739,082; 5,908,810 and 7,112,665.
[312] Other herbicide tolerant plants are plants made tolerant to herbicides that inhibit the enzyme hydroxyphenylpyruvate-dioxigenase (HPPD). HPPD is an enzyme that catalyzes the reaction through which parahydroxyphenylpyruvate (HPP) is transformed into homogentisate. Plants tolerant to HPPD inhibitors can be transformed with a gene encoding a naturally occurring resistant HPPD enzyme, or with a gene encoding a mutant or chimeric HPPD enzyme as described in WO 96/38567, WO 99/24585, WO 99 / 24586, WO 09/144079, WO 02/046387, or US 6 768 044. Tolerance to HPPD inhibitors can also be obtained by transforming plants with genes encoding certain enzymes that allow the formation of homogentisate despite inhibition of native HPPD enzyme by the HPPD inhibitor. These plants and genes are described in WO 99/34008 and WO 02/36787. Plant tolerance to HPPD inhibitors can also be improved by transforming plants with a gene encoding an enzyme with prefenate dehydrogenase (PDH) activity, in addition to a gene encoding an HPPD-tolerant enzyme, as described in WO 04 / 024928. In addition, plants can become more tolerant of HPPD-inhibiting herbicides by adding to their genome a gene encoding an enzyme capable of metabolizing or degrading HPPD-inhibitors, such as the CYP450 enzymes presented in WO 2007/103567 and WO 2008/150473.
[313] Still other herbicide resistant plants are plants made tolerant to acetolactate synthase (ALS) inhibitors. Known ALS inhibitors include, for example, sulfonylurea herbicides, imidazolinone, triazolopyrimidines, pyrimidinioxy (thio) benzoates and / or sulfonylaminocarbonyltriazolinone. It is known that different mutations in the ALS enzyme (also known as acetohydroxyacid synthase, AHAS) confer tolerance to different herbicides and groups of herbicides, as described, for example, in Tranel and Wright (Weed Science 2002, 50, 700-712), and also in US Patents 5,605,011 5 378 824 5 141 870 and 5,013,659. The production of sulfonylurea tolerant plants and imidazolinone tolerant plants is described in US Patents 5605011; 5013659; 5,141,870; 5767361; 5,731,180; 5,304,732; 4,761,373; 5,331,107; 5 928 937; and 5,378,824; and WO 96/33270. Other imidazolinone tolerant plants are described in, for example, WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093, WO 2006/007373, WO 2006/015376, WO 2006/024351, and WO 2006 / 060634. Sulphonylurea and imidazolinone tolerant plants are described in, for example, WO 2007/024782 and in U.S. Patent Application 61/288958.
[314] Other plants tolerant to imidazolinone and / or sulfonylurea can be obtained by induced mutagenesis, selection in cell cultures in the presence of the herbicide, or by random mutagenesis as described, for example, for soy in US 5,084,082, for rice in WO 97/41218, for sugar beet in US 5,773,702 and WO 99/057965, for lettuce in US 5,198,599, or for sunflower in WO 01/065922.
[315] Plants or cultivars (obtained by methods of plant biotechnology such as genetic engineering) that can also be treated according to the invention are transgenic plants resistant to insects, that is, plants taken resistant to attack by certain target insects. These plants can be obtained by genetic transformation, or by selecting plants with a mutation that gives them such resistance to insects.
[316] The term "transgenic insect resistant plant" as used herein includes any plant that contains at least one transgene with a coding sequence of: 1) an insecticidal crystalline protein from Bacillus thuringiensis or an insecticidal portion thereof, such as crystalline proteins insecticides listed in Crickmore et al. (1998, Microbiology and Molecular Biology Reviews, 62: 807- 813), updated by Crickmore et al. (2005) in the nomenclature of the toxin Bacillus thuringiensis at http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or its insecticidal portions, for example, proteins of the Cry protein classes, namely CrylAb, CrylAc, Cry1B, Cry1C, CryiD, CryiF, Cry2Ab, Cry3Aa, or Cry3Bb, or their insecticidal moieties (for example, EP-A 1 999 141 and WO 2007/107302), or proteins encoded by synthetic genes as, for example, described in US Patent Application 12/249,016; or 2) a crystalline protein from Bacillus thuringiensis or a portion thereof that is insecticidal in the presence of another second crystalline protein from Bacillus thuringiensis or a portion thereof, such as the binary toxin composed of the crystalline proteins Cry34 and Cry35 (Nat. Biotechnol. 2001 , 19, 668-72; Applied Environm. Microbiol. 2006, 71, 1765-1774), or the binary toxin consisting of the Cry1A or CryiF proteins and the Cry2Aa or Cry2Ab or Cry2Ae proteins (US Patent Application 12/214 022 and EP -A 2 300 618); or 3) a hybrid insecticidal protein composed of parts of different crystalline insecticidal proteins from Bacillus thuringiensis, such as a hybrid of the proteins in 1) behind or a hybrid of the proteins in 2) behind, for example, the Cry1A.1O5 protein produced by the event MON98034 corn (WO 2007/027777); or 4) a protein from any of the groups from 1) to 3) above, where some, particularly from 1 to 10, amino acids have been replaced by other amino acids in order to achieve greater insecticidal activity against a target insect species, and / or expand the range of affected target insect species, and / or due to changes introduced in the coding DNA during cloning or transformation, such as the Cry3Bb1 protein in the MON863 or MON88017 corn events, or the Cry3A protein in the corn MIR604; 5) an insecticidal protein secreted by Bacillus thuringiensis or Bacillus cereus, or an insecticidal portion thereof, such as the vegetative insecticidal proteins (VIP) listed at: http://www.lifesci.sussex.ac.uk/home/Neil_Crickmore/Bt /vip.html, for example, proteins of the VIP3Aa class; or 6) a protein secreted by Bacillus thuringiensis or Bacillus cereus, which is insecticidal in the presence of a second protein secreted by Bacillus thuringiensis or B. cereus, such as the binary toxin composed of the VIP1A and VIP2A proteins (WO 94/21795); or 7) a hybrid insecticidal protein composed of parts of different proteins secreted by Bacillus thuringiensis or Bacillus cereus, such as a hybrid of the proteins of 1) behind or a hybrid of the proteins of 2) behind; or 8) a protein from any of the groups from 5) to 7) above, where some, particularly from 1 to 10, amino acids have been replaced by other amino acids in order to achieve greater insecticidal activity against a target insect species, and / or expand the range of target insect species affected, and / or due to changes introduced in the coding DNA during cloning or transformation (further encoding an insecticidal protein), such as the VIP3Aa protein in the COT102 cotton event; or 9) a protein secreted by Bacillus thuringiensis or Bacillus cereus, which is insecticidal in the presence of a crystalline protein from Bacillus thuringiensis, such as the binary toxin composed of VIP3 and Cry1 A or Cry1 F (US Patent Application 61/126083 and 61 / 195019), or the binary toxin composed of the VIP3 protein and the Cry2Aa or Cry2Ab or Cry2Ae proteins (US Patent Application 12/214 022 and EP-A 2 300 618); 10) a protein from 9) ago in which some, particularly from 1 to 10, amino acids were replaced by another amino acid in order to achieve greater insecticidal activity against a target insect species, and / or to expand the range of insect species- affected, and / or due to changes introduced in the coding DNA during cloning or transformation (further encoding an insecticidal protein).
[317] Of course, a transgenic insect-resistant plant in the current context also includes any plant carrying a combination of genes encoding proteins in any of the classes 1 to 10 above. In one embodiment, an insect resistant plant contains more than one transgene encoding a protein from any of the previous classes 1 to 10 in order to expand the range of affected target insect species when using different proteins targeting different target insect species, or in order to delay the development of insect resistance to plants by means of different insecticidal proteins for the same target insect species but with a different mode of action, such as binding to different binding sites of receptors in the insect.
[318] A «insect resistant transgenic plant» as used herein further includes any plant carrying at least one transgene with a sequence that after expression produces a double-stranded RNA, which after ingestion by an agricultural insect pest inhibits growth of that insect pest, as described in, for example, WO 2007/080126, WO 2006/129204, WO 2007/074405, WO 2007/080127 and WO 2007/035650.
[319] Plants or cultivars (obtained by methods of plant biotechnology such as genetic engineering) that can also be treated according to the invention are tolerant to abiotic stresses. These plants can be obtained by genetic transformation, or by selecting plants that carry a mutation that confers such resistance to stress. Especially useful stress-tolerant plants include: 1) Plants carrying a transgene capable of reducing the expression and / or activity of the poly (ADP-ribose) -polymerase (PARP) gene in plant or plant cells as described in WO 00 / 04173, WO 2006/045633, EP-A 1 807 519, or EP-A 2 018 431. 2) Plants carrying a transgene to increase tolerance to stress that is capable of reducing the expression and / or activity of genes coding for plant PARG or plant cells as described, for example, in WO 2004/090140. 3) Plants carrying a transgene to increase tolerance to stress, which codes for a functional enzyme in the plant from the synthesis pathway by saving the nicotinamide and adenine dinucleotide, such as nicotinamidase, nicotinate-phosphoribosyltransferase, nicotinic acid mononucleotide adenyltransferase, nicotinamide and adepine synthetase dinucleotide or nicotinamide phosphoribosyltransferase, as described in, for example, EP-A 1 794 306, WO 2006/133827, WO 2007/107326, EP-A 1 999 263, or WO 2007 / 107326.
[320] Plants or cultivars (obtained by methods of plant biotechnology such as genetic engineering) that can also be treated according to the invention show changes in the quantity, quality and / or storage stability of the harvested product and / or changes in the properties of specific components of the harvested product, such as: 1) Transgenic plants that synthesize a modified starch, whose physical-chemical characteristics, in particular the amylose content or the amylose / amylopectin ratio, the degree of branching, the average chain length, the distribution of side chains, the behavior of viscosity, the consistency of the gel, the size of starch grains and / or the morphology of starch grains are different from those of starch synthesized in plant cells or wild type plants, the first being most suitable for special applications. Said transgenic plants that synthesize modified starch are described in, for example, EP-A 0 571 427, WO 95/04826, EP-A 0 719 338, WO 96/15248, WO 96/19581, WO 96/27674, WO 97/11188, WO 97/26362, WO 97/32985, WO 97/42328, WO 97/44472, WO 97/45545, WO 98/27212, WO 98/40503, WO 99/58688, WO 99/58690, WO 99/58654, WO 00/08184, WO 00/08185, WO 00/08175, WO 00/28052, WO 00/77229, WO 01/12782, WO 01/12826, WO 02/101059, WO 03/071860, WO 04/056999, WO 05/030942, WO 2005/030941, WO 2005/095632, WO 2005/095617, WO 2005/095619, WO 2005/095618, WO 2005/123927, WO 2006/018319, WO 2006/103107, WO 2006/108702, WO 2007/009823, WO 00/22140, WO 2006/063862, WO 2006/072603, WO 02/034923, WO 2008/017518, WO 2008/080630, WO 2008/080631, WO 2008/090008, WO 01/14569, WO 02/79410, WO 03/33540, WO 2004/078983, WO 01/19975, WO 95/26407, WO 96/34968, WO 98/20145, WO 99/12950, WO 99/66050, WO 99/53072, US 6,734,341, WO 00/11192, WO 98/22604, WO 98/32326, WO 01/98509, WO 01/98509, WO 2005/002359, US 5,824,790, US 6,013,861, WO 94/04693, WO 94/09144, WO 94/11520, WO 95/35026, WO 97/20936, WO 2010/012796, WO 2010/003701, 2) Transgenic plants that synthesize carbohydrate polymers that not starch, or which synthesize polymers of carbohydrates other than starch with altered properties compared to wild type plants without genetic modification. Examples are plants that produce polyfructose, especially of the inulin and levan type, as disclosed in EP-A 0 663 956, WO 96/01904, WO 96/21023, WO 98/39460 and WO 99/24593, plants that produce alpha-1 , 4-glucans, as disclosed in WO 95/31553, US 2002031826, US 6 284 479, US 5,712,107, WO 97/47806, WO 97/47807, WO 97/47808 and WO 00/14249, plants that produce alpha -1,4-glucans branched in alpha-1,6, as disclosed in WO 00/73422, plants that produce alternan, as disclosed in, for example, WO 00/47727, WO 00/73422, US 5 908 975 and EP -A 0 728 213, 3) Transgenic plants that produce hyaluronic acid, as disclosed in, for example, WO 2006/032538, WO 2007/039314, WO 2007/039315, WO 2007/039316, JP-A 2006-304779 and WO 2005/012529. 4) Transgenic or hybrid plants, such as onions with characteristics such as a "high soluble solids content", "low pungency" (LP) and / or "long storage" (LS), as described in US Patent Application 12/020 360.
[321] Plants or cultivars (which can be obtained by methods of plant biotechnology such as genetic engineering) that can also be treated according to the invention are plants, like cotton plants, with altered fiber characteristics. These plants can be obtained by genetic transformation or by selecting plants with a mutation that confers such altered fiber characteristics and include: a) Plants, such as cotton plants, that contain an altered form of cellulose synthase genes, as described in WO 98/00549. b) Plants, such as cotton plants, that contain an altered form of homologous nucleic acids rsw2 or rsw3, as described in WO 2004/053219. c) Plants, such as cotton plants, with an increase in sucrose synthase phosphate expression, as described in WO 01/17333. d) Plants, such as cotton plants, with an increase in sucrose synthase expression, as described in WO 02/45485. e) Plants, such as cotton plants, in which the synchronization of the gating in the plasmodesms at the base of the fiber cell has been altered, for example, by the lack of regulation of the fiber-selective β-1,3-glucanase, as described in WO 2005/017157 or WO 2009/143995. f) Plants, such as cotton plants, where the fibers exhibit an altered reactivity, for example, by the expression of the N-acteylglucosamine transferase gene, including the nodC and chitin synthase genes, as described in WO 2006/136351 .
[322] Plants or cultivars (which can be obtained by methods of plant biotechnology such as genetic engineering) that can also be treated according to the invention are plants, such as rapeseed or brassica, with altered oil characteristics. These plants can be obtained by genetic transformation or by selecting plants with a mutation that gives them these altered oil characteristics and include: a) Plants, such as rapeseed plants, which produce oil with a high oleic acid content, as described in, for example, US 5 969 169, US 5 840 946, US 6 323 392 or US 6 063 947. b) Plants, such as rapeseed plants, that produce oil with a low content of linolenic acid, as described in US 6 270 828, US 6 169 190, or US 5 965 755. c) Plants, such as rapeseed plants, which produce oil with a low content of saturated fatty acids, as described, for example, in US 5 434 283 or Patent Application 12/668303.
[323] The plants or cultivars (which can be obtained by methods of plant biotechnology such as genetic engineering) that can also be treated according to the invention are plants, such as rapeseed or brassica plants, with altered natural threshing characteristics. These plants can be obtained by genetic transformation or by selecting plants that carry a mutation that gives these altered natural threshing characteristics, and include plants such as rapeseed plants with delayed or reduced natural threshing, as described in US Patent Application 61/135 230, WO 2009/0683131 and WO 2010/006732.
[324] Plants or cultivars (which can be obtained by methods of plant biotechnology such as genetic engineering) that can also be treated according to the invention are plants, such as the tobacco plant, with altered patterns of post-translational protein modifications, for example, as described in WO 2010/121818 and WO 2010/145846.
[325] Particularly useful transgenic plants that can be treated according to the invention are plants that carry transformation events, or a combination of transformation events, which are the subject of applications for "unregulated" status in the United States of America. America, addressed to the Plant Healt Inspection Service (APHIS) of the United States Department of Agriculture (USDA), whether these applications have been approved or remain pending. This information can be readily obtained, at any time, from APHIS (4700 River Road, Riverdale, MD 20737, USA), for example through its website (URL http://www.aphis.usda.gov/brs/not_reg. html). At the date of filing this application, applications for unregulated status that were still pending or that had been approved by APHIS were those that contained the following information: • Application: application identification number. Technical descriptions of the transformation events are found in individual order documents obtained from APHIS, for example on the APHIS website, by reference to that order number. These descriptions are incorporated into this document by reference. • Order extension: reference to a previous order for which an extension is requested. • Institution: name of the entity that submits the request. • Regulated article: the species of plant in question. • Transgenic phenotype: the characteristic given to the plant by the transformation event. • Transformation event or line: the name of the event or events (sometimes also referred to as line or lines) for which non-regulated status is requested. • APHIS Documents: several documents published by APHIS in relation to the Order and which can be requested from APHIS.
[326] Other particularly useful plants carrying unique transformation events or combinations of transformation events are listed, for example, in the databases of various national or regional regulatory agencies (see for example http://gmoinfo.jrc.it/ gmp_browse.aspx and http://www.aqbios.com/dbase.fp).
[327] Particularly useful transgenic plants that can be treated according to the invention are plants that contain transformation events, or a combination of transformation events, and which are listed, for example, in the databases of various national regulatory agencies or regional, including Event 1143-14A (cotton, insect control, not deposited, described in WO 2006/128569); Event 1143-51B (cotton, insect control, not deposited, described in WO 2006/128570); Event 1445 (cotton, herbicide tolerance, not deposited, described in US-A 2002-120964 or WO 02/034946); Event 17053 (rice, herbicide tolerance, deposited as PTA-9843, described in WO 2010/117737); Event 17314 (rice, herbicide tolerance, deposited as PTA-9844, described in WO 2010/117735); Event 281-24-236 (cotton, insect control - herbicide tolerance, deposited as PTA-6233, described in WO 2005/103266 or US-A 2005-216969); Event 3006-210-23 (cotton, insect control - herbicide tolerance, deposited as PTA-6233, described in US-A 2007-143876 or WO 2005/103266); Event 3272 (corn, quality characteristic, deposited as PTA-9972, described in WO 2006/098952 or US-A 2006-230473); Event 40416 (corn, insect control - herbicide tolerance, deposited as ATCC PTA-11508, described in WO 2011/075593); Event 43A47 (corn, insect control - herbicide tolerance, deposited as ATCC PTA-11509, described in WO 2011/075595); Event 5307 (corn, insect control, deposited as ATCC PTA-9561, described in WO 2010/077816); Event ASR-368 (bent grass, herbicide tolerance, deposited as ATCC PTA-4816, described in US-A 2006-162007 or WO 2004/053062); Event B16 (maize, herbicide tolerance, not deposited, described in US-A 2003-126634); Event BPS-CV127-9 (soybean, herbicide tolerance, deposited as NCIMB No. 41603, described in WO 2010/080829); Event CE43-67B (cotton, insect control, deposited as DSM ACC2724, described in US-A 2009-217423 or WO 2006/128573); Event CE44 - 69D (cotton, insect control, not deposited, described in US-A 2010- 0024077); Event CE44 - 69D (cotton, insect control, not deposited, described in WO 2006/128571); Event CE46-02A (cotton, insect control, not deposited, described in WO 2006/128572); Event COT102 (cotton, insect control, not deposited, described in US-A 2006-130175 or WO 2004/039986); Event COT202 (cotton, insect control, not deposited, described in US-A 2007-067868 or WO 2005/054479); Event COT203 (cotton, insect control, not deposited, described in WO 2005/054480); DAS40278 event (corn, herbicide tolerance, deposited as ATCC PTA-10244, described in WO 2011/022469); Event DAS-59122-7 (corn, insect control - herbicide tolerance, deposited as ATCC PTA 11384, described in US-A 2006-070139); Event DAS-59132 (corn, insect control - herbicide tolerance, not deposited, described in 2009/100188); Event DAS-68416 (soybean, herbicide tolerance, deposited as ATCC PTA-10442, described in 066384/2011 WO or WO 2011/066360); Event DP-098140-6 (corn, herbicide tolerance, deposited as ATCC PTA-8296, described in US-A 2009-137395 or WO 2008/112019); Event DP-305423-1 (soybean, quality characteristic, not deposited, described in US-A-2008 312082 or WO 2008/054747); Event DP-32138-1 (corn, hybridization system, deposited as ATCC PTA-9158, described in US-A 2009- 0210970 or WO 2009/103049); Event DP-356043-5 (soybean, herbicide tolerance, deposited as ATCC PTA-8287, described in US-A 2010-0184079 or WO 2008/002872); Event EE-1 (eggplant, insect control, not deposited, described in WO 2007/091277); Event FI117 (corn, herbicide tolerance, deposited as ATCC 209031, described in US-A 2006-059581 or WO 98/044140); Event GA21 (corn, herbicide tolerance, deposited as ATCC 209033, described in US-A 2005-086719 or WO 98/044140); Event GG25 (corn, herbicide tolerance, deposited as ATCC 209032, described in US-A 2005-188434 or WO 98/044140); Event GHB119 (cotton, insect control - herbicide tolerance, deposited as ATCC PTA-8398, described in WO 2008/151780); Event GHB614 (cotton, herbicide tolerance, deposited as ATCC PTA-6878, described in US-A 2010-050282 or WO 2007/017186); Event GJ11 (corn, herbicide tolerance, deposited as ATCC 209030, described in US-A 2005-188434 or WO 98/044140); GM RZ13 event (sugar beet, virus resistance, deposited as NCIMB-41601, described in WO 2010/076212); Event H7-1 (sugar beet, herbicide tolerance, deposited as NCIMB 41158 or NCIMB 41159, described in US-A 2004-172669 or WO 2004/074492); Event J0PLIN1 (wheat, disease tolerance, not deposited, described in US-A 2008-064032); Event LL27 (soybean, herbicide tolerance, deposited as NCIMB41658, described in WO 2006/108674 or US-A 2008-320616); Event LL55 (soybean, herbicide tolerance, deposited as NCIMB 41660, described in WO 2006/108675 or US-A 2008-196127); Event LLcotton25 (cotton, herbicide tolerance, deposited as ATCC PTA-3343, described in WO 03/013224 or US-A 2003-097687); Event LLRICE06 (rice, herbicide tolerance, deposited as ATCC-23352, described in US 6 468 747 or WO 00/026345); Event LLRICE601 (rice, herbicide tolerance, deposited as ATCC PTA-2600, described in US-A 2008-2289060 or WO 00/026356/00); Event LI038 (maize, quality characteristic, deposited as ATCC PTA-5623, described in US-A 2007-028322 or WO 2005/061720); Event MIR162 (corn, insect control, deposited as PTA-8166, described in US-A 2009-300784 or WO 2007/142840); Event MIR604 (corn, insect control, not deposited, described in US-A 2008- 167456 or WO 2005/103301); Event MON15985 (cotton, insect control, deposited as ATCC PTA-2516, described in US-A 2004-250317 or WO 02/100163); MON810 event (corn, insect control, not deposited, described in US-A 2002-102582); MON863 event (corn, insect control, deposited as ATCC PTA-2605, described in WO 2004/011601 or US-A 2006-095986); Event MON87427 (corn, pollination control, deposited as ATCC PTA-7899, described in WO 2011/062904); Event MON87460 (corn, stress tolerance, deposited as ATCC PTA-8910, described in WO 2009/111263 or US-A 2011-0138504); MON87701 event (soybean, insect control, deposited as ATCC PTA-8194, described in US-A 2009-130071 or WO 2009/064652); Event MON87705 (soybean, quality characteristic - herbicide tolerance, deposited as ATCC PTA-9241, described in US-A 2010-0080887 or WO 2010/037016); Event MON87708 (soybean, herbicide tolerance, deposited as ATCC PTA9670, described in WO 2011/034704); Event MON87754 (soybean, quality characteristic, deposited as ATCC PTA-9385, described in WO 2010/024976); Event MON87769 (soybean, quality characteristic, deposited as ATCC PTA-8911, described in US-A 2011-0067141 or WO 2009/102873); Event MON88017 (corn, insect control - herbicide tolerance, deposited as ATCC PTA-5582, described in US-A 2008-028482 or WO 2005/059103); Event MON88913 (cotton, herbicide tolerance, deposited as ATCC PTA-4854, described in WO 2004/072235 or US-A 2006-059590); Event MON89034 (corn, insect control, deposited as ATCC PTA-7455, described in WO 2007/140256 or US-A 2008-260932); Event MON89788 (soybean, herbicide tolerance, deposited as ATCC PTA-6708, described in US-A 2006-282915 or WO 2006/130436); Event MS11 (rapeseed, pollination control - herbicide tolerance, deposited as ATCC PTA-850 or PTA-2485, described in WO 01/031042); Event MS8 (rapeseed, pollination control - herbicide tolerance, deposited as ATCC PTA-730, described in WO 01/041558 or US-A 2003-188347); Event NK603 (corn, herbicide tolerance, deposited as ATCC PTA-2478, described in US-A 2007-292854); Event PE-7 (rice, insect control, not deposited, described in WO 2008/114282); Event RF3 (rapeseed, pollination control - herbicide tolerance, deposited as ATCC PTA-730, described in WO 01/041558 or US-A 2003-188347); Event RT73 (rapeseed, herbicide tolerance, not deposited, described in WO 02/036831 or US-A2008-070260); Event T227-1 (sugar beet, herbicide tolerance, not deposited, described in WO 02/44407 or US-A 2009-265817); Event T25 (corn, herbicide tolerance, not deposited, described in US-A 2001-029014 or WO 01/051654); Event T304-40 (cotton, insect control - herbicide tolerance, deposited as ATCC PTA-8171, described in US-A 2010-077501 or WO 2008/122406); Event T342-142 (cotton, insect control, not deposited, described in 2006/128568); Event TC1507 (corn, insect control - herbicide tolerance, not deposited, described in US-A 2005-039226 or WO 2004/099447); Event VIP1034 (corn, insect control - herbicide tolerance, deposited as ATCC PTA-3925., Described in WO 03/052073), Event 32316 (corn, insect control-herbicide tolerance, deposited as PTA-11507, described in WO 2011/084632), Event 4114 (corn, insect control-tolerance to herbicide, deposited as PTA-11506, described in WO 2011/084621). Application periods and fees
[328] In the combinations according to the invention, compounds A and B are present in a synergistically effective weight ratio A: B, in a range of 100: 1 to 1: 100, preferably in a weight ratio of 50 : 1 to 1:50, more preferably in a weight ratio of 20: 1 to 1:20. Other A: B ratios that can be used according to the present invention in order of increasing preference are: from 1000: 1 to 1: 1000, from 750: 1 to 1: 750, from 500: 1 to 1: 500, 400: 1 to 1: 400, 300: 1 to 1: 300, 250: 1 to 1: 250, 200: 1 to 1: 250, 175: 1 to 1: 175, 150: 1 to 1: 150, 125: 1 to 1: 125, 95: 1 to 1:95, 90: 1 to 1:90, 85: 1 to 1:85, 80: 1 to 1:80, 75: 1 to 1:75, 70: 1 to 1:70, 65: 1 to 1:65, 60: 1 to 1:60, 55: 1 to 1:55, 45: 1 to 1 : 45, from 40: 1 to 1:40, from 35: 1 to 1:35, from 30: 1 to 1:30, from 25: 1 to 1:25, from 15: 1 to 1:15, from 10 : 1 to 1:10, 5: 1 to 1: 5, 4: 1 to 1: 4, 3: 1 to 1: 3, 2: 1 to 1: 2.
[329] For fungicidal compositions, a weight ratio (A) :( B) of 1: 100 to 10: 1, more preferably 1:10 to 10: 1 is preferred.
[330] According to the invention, the term "combination" means the various combinations of compounds (A) and (B), for example, in a single "ready to use" form, in a combined spray mixture composed of formulations separate from individual active compounds, such as a 'ready to mix' mixture, and in a combined use of the individual active ingredients carried out sequentially, that is, one after the other, in a reasonably short period, such as a few hours or days. Preferably, the order of application of compounds (A) and (B) is not essential for the operation of the present invention.
[331] When using the inventive active ingredients as fungicides, application rates can vary over a relatively wide range, depending on the type of application. The application rate of the inventive active ingredients is: • in the case of treatment of plant parts, for example, leaves: from 0.1 to 10 000 g / ha, preferably from 10 to 1000 g / ha, more preferably from 10 to 800 g / ha, even more preferably 50 to 300 g / ha (in the case of irrigation or drip application, it is possible to reduce the application rate, especially when inert substrates such as rock wool or perlite); • in the case of seed treatment: from 2 to 200 g / 100 kg of seeds, • in the case of soil treatment: from 0.1 to 10,000 g / ha, preferably from 1 to 5000 g / ha.
[332] These application rates are illustrative only and are not limiting for the purposes of the invention.
[333] The active ingredients or compositions of the invention can thus be used to protect plants against attack by said pathogens, for some time after treatment. The protection period generally extends from 1 to 28 days, preferably from 1 to 14 days, more preferably from 1 to 10 days, even more preferably from 1 to 7 days, after treating the plants with the active ingredients, or up to 200 days after seed treatment.
[334] The treatment method according to the invention also provides for the use or application of compounds (A) and (B) in a simultaneous, separate or sequential manner. If the individual active ingredients are applied sequentially, that is, at different times, then they are applied one after the other, within a reasonably short period of a few hours or days. Preferably, the order of application of compounds (A) and (B) is not essential for the operation of the present invention.
[335] In a particularly advantageous manner, the aforementioned plants can be treated according to the invention with the compounds of the general formula (I) and with the inventive compositions. The preferred ranges mentioned above for the active ingredients or compositions also apply to the treatment of these plants. Special emphasis is placed on the treatment of plants with the compounds or compositions specifically referred to in this text.
[336] According to the present invention, a synergistic effect, for example, of fungicides, is always present when the fungicidal activity of the combinations of active compounds exceeds the total activities of the active compounds applied individually. The expected activity for a given combination of two active compounds (binary composition) can be calculated as follows:

[337] where E represents the expected percentage of disease inhibition for the combination of two fungicides at defined doses (for example, equal to x and y respectively), x is the observed percentage of disease inhibition by compound (A) at a defined dose (equal to x), y is the observed percentage of disease inhibition by compound (B) at a defined dose (equal to y). When the percentage of inhibition observed for the combination is greater than E, there is a synergistic effect.
[338] The expected activity for a given combination of three active compounds (ternary composition) can be calculated as follows:
on what
[339] X is the effectiveness when the active compound A is applied at an application rate of m ppm (or g / ha),
[340] Y is the effectiveness when the active compound B is applied at an application rate of n ppm (or g / ha),
[341] Z is the effectiveness when the active compound C is applied at an application rate of r ppm (or g / ha),
[342] E is the effectiveness when the active compounds A, B and C are applied at the application rates of m, n and r ppm (or g / ha), respectively.
[343] The degree of effectiveness is expressed in%. 0% is the effectiveness corresponding to the control, while a 100% effectiveness means that no disease was observed.
[344] If the actual activity exceeds the calculated value, then the activity of the combination is superadditive, that is, there is a synergistic effect. In this case, the effectiveness actually observed must be greater than the value of the expected effectiveness (E) calculated by the aforementioned formula.
[345] Another way of demonstrating a synergistic effect is the Tammes method (cf. "Isoboles, the graphic representation of synergism in pesticides" in Neth. J. Plant Path., 1964, 70, 73-80).
[346] The present invention will now be illustrated using the following examples. However, the invention is not limited by the examples. Example A Test with Alternaria (tomato) Zpreventivo Solvent: 24.5 parts by weight of acetone 24.5 parts by weight of dimethylacetamide Emulsifier: 1 part by weight of alkylaryl polyglycolic ether
[347] In order to produce a suitable preparation of the active compound, 1 part by weight of the active compound is mixed with the indicated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.
[348] To test the preventive activity, young plants are sprayed with the preparation of the active compound at the indicated application rate. After drying the spray coating, the plants are inoculated with an aqueous spore suspension of Alternaria solani. The plants are then placed in an incubator at about 20 ° C and 100% relative humidity.
[349] The test is evaluated 3 days after inoculation. 0% is the effectiveness corresponding to the control, while a 100% effectiveness means that no disease was observed.
[350] The results of the table below clearly show that the activity observed for the combination of active compounds according to the invention is superior to the calculated activity, that is, there is a synergistic effect. Table A1 Test with Alternaria (tomato) Zpreventivo
* Obser. = observed activity ** Calc. = activity calculated using the Colbi formula Table A2 Test with Alternaria (tomato) / preventive
* Observ. = observed activity ** Calc. = activity calculated using the Colbi formula Example B Test with Blumeria (tomato) / preventive Solvent: 49 parts by weight of N, N-dimethylacetamide Emulsifier: 1 part by weight of alkylaryl polyglycolic ether
[351] In order to produce a suitable preparation of the active compound, 1 part by weight of active compound or combination of active compounds is mixed with the indicated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.
[352] To test the preventive activity, young plants are sprayed with the preparation of the active compound at the indicated application rate. After drying the spray coating, the plants are sprinkled with spores of Blumería graminis f.sp. hordei.
[353] The plants are then placed in a greenhouse at a temperature of around 18 ° C and a relative atmospheric humidity of about 80% to promote the development of mold pustules.
[354] The test is evaluated 7 days after inoculation. 0% is the effectiveness corresponding to the control, while a 100% effectiveness means that no disease was observed.
[355] The results in the following table clearly show that the activity observed for the combination of active compounds according to the invention is greater than the calculated activity, that is, there is a synergistic effect. Table B1 Blumeria test (barley) / preventive

* Obser. = the observed activity ** Calc. = activity calculated using the Coibi formula Example C Test with Leptosphaeria nodorum (tomato) / preventive Solvent: 49 parts by weight of N, N-dimethylacetamide Emulsifier: 1 part by weight of alkylaryl polyglycolic ether
[356] In order to produce a suitable preparation of the active compound, 1 part by weight of active compound or combination of active compounds is mixed with the indicated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.
[357] To test the preventive activity, young plants are sprayed with the preparation of the active compound at the indicated application rate. After drying the sprayed coating, the plants are sprayed with a spore suspension of Leptosphaeria nodorum. The plants are kept in an incubator at about 20 ° C and a relative humidity of 100%.
[358] The plants are then placed in a greenhouse at a temperature of about 22 ° C and a relative atmospheric humidity of about 80%.
[359] The test is evaluated 8 days after inoculation. 0% is the effectiveness corresponding to the control, while a 100% effectiveness means that no disease was observed.
[360] The results in the table below clearly show that the activity observed for the combination of active compounds according to the invention is greater than the calculated activity, that is, there is a synergistic effect. Table C1 Test with Leptosphaeria nodorum (wheat) Zpreventivo
* Observ. = observed activity ** Calc. = activity calculated using the Colbi formula Example D Test with Phakopsora (soy) / preventive Solvent: 24.5 parts by weight of acetone 24.5 parts by weight of dimethylacetamide Emulsifier: 1 part by weight of alkylaryl polyglycolic ether
[361] In order to produce a suitable preparation of the active compound, 1 part by weight of the active compound is mixed with the indicated amount of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.
[362] To test the preventive activity, young plants are sprayed with the preparation of the active compound at the indicated application rate. After drying the spray coating, the plants are inoculated with an aqueous spore suspension of the soybean rusting agent (Phakopsora pachirhizi) and are kept for 24 hours, without light, in an incubator at about 24 ° C and humidity 95% relative atmospheric pressure.
[363] The plants remain in the incubator at about 24 ° C and a relative atmospheric humidity of about 80% and with a 12-hour day / night cycle.
[364] The test is evaluated 7 days after inoculation. 0% is the effectiveness corresponding to the control, while a 100% effectiveness means that no disease was observed.
[365] The results of the table below clearly show that the activity observed for the combination of active compounds according to the invention is superior to the calculated activity, that is, there is a synergistic effect. Table D1 Test with Phakopsora (soy) Zpreventivo

* Observ. ** Calc. = activity = activity calculated by the observed Coibi formula Table D2 Test with Phakopsora (soy) Zpreventivo

Observ. = observed activity Cale. = activity calculated using the Coibi formula Example E Test with Puccinia triticin (wheat) Zpreventivo Solvent: 49 parts by weight of N, N-dimethylacetamide Emulsifier: 1 part by weight of alkylaryl polyglycolic ether
[366] In order to produce a suitable preparation of the active compound, 1 part by weight of active compound or combination of active compounds is mixed with the indicated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.
[367] To test preventive activity, young plants are sprayed with the preparation of the active compound or combination of active compounds at the indicated application rate.
[368] After the spray coating has dried, the plants are sprayed with a spore suspension of Puccinia tritycin. The plants are kept for 48 hours in an incubator at about 20 ° C and a relative atmospheric humidity of 100%.
[369] The plants are then placed in a greenhouse at a temperature of about 20 ° C and a relative atmospheric humidity of about 80%.
[370] The test is evaluated 8 days after inoculation. 0% is the effectiveness corresponding to the control, while a 100% effectiveness means that no disease was observed.
[371] The results in the following table clearly show that the activity observed for the combination of active compounds according to the invention is greater than the calculated activity, that is, there is a synergistic effect. Table E1 Test with Puccinia triticina (wheat) Zpreventivo

Example F Test with Pirenophora teres (barley) Zpreventivo Solvent: 49 parts by weight of N, N-dimethylacetamide Emulsifier: 1 part by weight of alkylaryl polyglycolic ether
[372] In order to produce a suitable preparation of the active compound, 1 part by weight of active compound or combination of active compounds is mixed with the indicated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.
[373] To test preventive activity, young plants are sprayed with the preparation of the active compound or combination of active compounds at the indicated application rate.
[374] After drying the sprayed coating, the plants are sprayed with a spore suspension of Pirenophora teres. The plants are kept for 48 hours in an incubator at about 20 ° C and a relative atmospheric humidity of 100%.
[375] The plants are then placed in a greenhouse at a temperature of about 20 ° C and a relative atmospheric humidity of about 80%.
[376] The test is evaluated 8 days after inoculation. 0% is the effectiveness corresponding to the control, while a 100% effectiveness means that no disease was observed.
[377] The results of the table below clearly show that the activity observed for the combination of active compounds according to the invention is greater than the calculated activity, that is, there is a synergistic effect. Table F1 Test with Pirenophora teres (barley) / preventive

1 Observation = a 2 * Shut. = activity calculated by the observed activity of Coibi formula Example G Test with Sphaeroteca (cucumbers) Zpreventivo Solvent: 24.5 parts by weight of acetone 24.5 parts by weight of dimethylacetamide Emulsifier: 1 part by weight of alkylaryl polyglycolic ether
[378] In order to produce a suitable preparation of the active compound, 1 part by weight of the active compound is mixed with the indicated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.
[379] To test the preventive activity, young plants are sprayed with the preparation of the active compound at the indicated application rate. After drying the spray coating, the plants are inoculated with an aqueous spore suspension of Sphaeroteca fuliginea. The plants are then placed in a greenhouse at about 23 ° C and a relative atmospheric humidity of 70%.
[380] The test is evaluated 7 days after inoculation. 0% is the effectiveness corresponding to the control, while a 100% effectiveness means that no disease was observed.
[381] The results in the table below clearly show that the activity observed for the combination of active compounds according to the invention is greater than the calculated activity, that is, there is a synergistic effect. Table G1 Test with Sphaeroteca (cucumbers) Zpreventivo Active compounds Application rate of active compound Efficacy (%)

* Observ. = observed activity ** Calc. = activity calculated using the Colbi formula Example H Test with Uromices (beans) / preventive Solvent: 24.5 parts by weight of acetone 24.5 parts by weight of N, N-dimethylacetamide Emulsifier: 1 part by weight of alkylaryl polyglycolic ether
[382] In order to produce a suitable preparation of the active compound, 1 part by weight of active compound is mixed with the indicated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.
[383] To test the preventive activity, young plants are sprayed with the preparation of the active compound at the indicated application rate. After drying the spray coating, the plants are inoculated with an aqueous spore suspension of the rust-causing agent in beans (Uromices appendiculatus) and are kept for 1 day in an incubator at about 20 ° C and a relative humidity of 100% .
[384] The plants are then placed in a greenhouse at a temperature of about 21 ° C and a relative atmospheric humidity of about 90%.
[385] The test is evaluated 10 days after inoculation. 0% is the effectiveness corresponding to the control, while a 100% effectiveness means that no disease was observed.
[386] The results in the table below clearly show that the activity observed for the combination of active compounds according to the invention is greater than the calculated activity, that is, there is a synergistic effect. Table H1 Test with Uromices (beans) / preventive

* Observ. = Observed activity Calc. = activity calculated using the Coibi formula Table H2 Test with Uromices (beans) / preventive
* Observ. = Observed activity Table H3 Test with Uromices (beans) / preventive
* Observ. = observed activity ** Calc. = activity calculated using the Colbi formula Example I Venturia (apple) test Solvent: 24.5 parts by weight of acetone 24.5 parts by weight of N, N-dimethylacetamide Emulsifier: 1 part by weight of alkylaryl polyglycolic ether
[387] In order to produce a suitable preparation of the active compound, 1 part by weight of active compound is mixed with the indicated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.
[388] To test the preventive activity, young plants are sprayed with the preparation of the active compound at the indicated application rate. After drying the spray coating, the plants are inoculated with an aqueous conidia suspension of the agent causing the stone in the apple (Venturia inaequalis) and are kept in an incubator at about 20 ° C and a relative atmospheric humidity of 100%.
[389] The plants are then placed in a greenhouse at a temperature of about 21 ° C and a relative atmospheric humidity of about 90%.
[390] The test is evaluated 10 days after inoculation. 0% is the effectiveness corresponding to the control, while a 100% effectiveness means that no disease was observed.
[391] The results of the table below clearly show that the activity observed for the combination of active compounds according to the invention is greater than the calculated activity, that is, there is a synergistic effect. Table 11 Test with Venturia (apple) Zpreventivo

* Observ. observed activity ** Calc. = activity calculated using the Colbi formula

权利要求:
Claims (5)
[0001]
1. Combination of compounds characterized by comprising: (A) a compound of the formula (ld)
[0002]
2. Compositions characterized by comprising combinations of active compounds according to claim 1 and by additionally comprising auxiliary substances, solvents, carriers, surfactants or extenders.
[0003]
3. Method for controlling phytopathogenic fungi in the field of crop protection, characterized by the fact that the combinations of active compounds as defined in claim 1 or the compositions according to claim 2 are applied to the seed, plant, fruit of plants or in the soil on which the plant grows or is expected to grow.
[0004]
4. Use of combinations of active compounds as defined in Claim 1, or compositions as defined in Claim 2, characterized by the fact that it is for the control of unwanted phytopathogenic fungi in the field of crop protection.
[0005]
5. Use of combinations of active compounds as defined in claim 1, or compositions as defined in claim 2, characterized in that it is for the treatment of seeds, seeds of transgenic plants and transgenic plants.

类似技术:

---

公开号 | 公开日 | 专利标题

---

US11147274B2|2021-10-19|Active compound combinations containing a thiazoylisoxazoline and a fungicide

---

US9668477B2|2017-06-06|Active compound combinations

---

JP5870186B2|2016-02-24|Active compound combination comprising | carboxamide derivative and fungicidal active compound

---

US9572343B2|2017-02-21|Active compound combinations

---

AU2012244533B8|2016-06-16|Active compound combinations comprising a |carboxamide derivative and a fungicidal compound

同族专利:

---

公开号 | 公开日

---

WO2014037314A2|2014-03-13|

---

CL2015000569A1|2015-07-17|

---

US20150201616A1|2015-07-23|

---

CA2883801A1|2014-03-13|

---

US9668477B2|2017-06-06|

---

KR20150052853A|2015-05-14|

---

CN104754940B|2018-01-30|

---

MX2015002884A|2015-07-06|

---

BR112015004968A2|2017-07-04|

---

CN104754940A|2015-07-01|

---

EP2892341B1|2017-04-26|

---

JP2015531343A|2015-11-02|

---

AR092462A1|2015-04-22|

---

EP2892341A2|2015-07-15|

---

WO2014037314A3|2014-05-15|

---

EA201500296A1|2015-08-31|

引用文献:

---

公开号 | 申请日 | 公开日 | 申请人 | 专利标题

---

---

GB9902592D0|1999-02-06|1999-03-24|Hoechst Schering Agrevo Gmbh|Fungicides|

---

FR2829362B1|2001-09-10|2003-11-07|Aventis Cropscience Sa|FUNGICIDAL COMPOSITION BASED ON ARYLAMIDINE DERIVATIVES AND KNOWN FUNGICIDAL COMPOUNDS|

---

EP1570736A1|2004-03-05|2005-09-07|Bayer CropScience S.A.|Fungicide composition comprising an arylamidine derivative and known fungicide compounds|

---

MXPA06014019A|2004-06-03|2007-02-08|Du Pont|Fungicidal mixtures of amidinylphenyl compounds.|

---

EP1931622B1|2005-09-13|2011-08-24|Bayer CropScience AG|Phenyloxy substituted phenylamidine derivatives as pesticides|

---

EP1926718B1|2005-09-13|2012-09-05|Bayer CropScience AG|Pesticide thiazolyloxy substituted phenylamidine derivatives|

---

US9668477B2|2012-09-07|2017-06-06|Bayer Cropscience Ag|Active compound combinations|US9668477B2|2012-09-07|2017-06-06|Bayer Cropscience Ag|Active compound combinations|

---

CN104381267B|2014-12-09|2016-03-30|北京燕化永乐生物科技股份有限公司|A kind of bactericidal composition|

---

EP3011832A1|2015-06-15|2016-04-27|Bayer CropScience AG|Fungicidal combination comprising phenoxyphenylamidines and further fungicide|

---

LT3307707T|2015-06-15|2021-01-11|Syngenta Crop Protection Ag|Halogen-substituted phenoxyphenylamidines and the use thereof as fungicides|

---

EP3307706B1|2015-06-15|2019-07-24|Bayer CropScience AG|Halogen-substituted phenoxyphenylamidines and the use thereof as fungicides|

---

CN107922317A|2015-07-08|2018-04-17|拜耳农作物科学股份公司|Phenoxy group halogen benzene carbon amidine class and its purposes as fungicide|

---

UA107868U|2015-12-21|2016-06-24|Товариство З Обмеженою Відповідальністю "Альфа Хімгруп"|FUNGICID COMPOSITION FOR CONTROL OF WHEAT DISEASES|

---

JP2017165720A|2016-03-11|2017-09-21|住友化学株式会社|Plant disease control composition and plant disease control method|

---

CN109788758A|2016-09-13|2019-05-21|巴斯夫欧洲公司|Insecticide mixtures|

---

WO2018109002A1|2016-12-14|2018-06-21|Bayer Cropscience Aktiengesellschaft|Active compound combinations|

---

EP3335559A1|2016-12-14|2018-06-20|Bayer CropScience Aktiengesellschaft|Active compound combinations|

---

EP3554241A2|2016-12-14|2019-10-23|Bayer CropScience Aktiengesellschaft|Phenoxyphenylamidines and the use thereof as fungicides|

---

EP3555044A1|2016-12-14|2019-10-23|Bayer CropScience Aktiengesellschaft|Phenylamidines and the use thereof as fungicides|

---

IT201700033543A1|2017-03-27|2018-09-27|Isagro Spa|PYRIDYL-FORMAMIDINE FOR FUNGICIDE ACTIVITY, THEIR AGRONOMIC COMPOSITIONS AND RELATED USE|

---

US20210122710A1|2017-04-20|2021-04-29|Pi Industries Ltd.|Novel phenylamine compounds|

---

CN106900747A|2017-04-22|2017-06-30|北京科发伟业农药技术中心|Bactericidal composition containing potassium phosphite|

---

CN110573014B|2017-04-27|2022-02-11|Upl有限公司|Fungicidal combinations|

---

EP3625215A1|2017-05-18|2020-03-25|PI Industries Ltd|Formimidamidine compounds useful against phytopathogenic microorganisms|

---

BR112021006019A2|2018-10-19|2021-06-29|Basf Se|fungicidal mixtures, pesticidal composition, use of the mixture and method for controlling phytopathogenic pests|

---

EP3643175A1|2018-10-24|2020-04-29|Basf Se|Ternary pesticidal mixtures containing metyltetraprole and fenpropimorph|

---

CN109503510B|2019-01-03|2020-07-03|山东大学|Antibacterial thiazole compound for preventing caries and preparation method thereof|

---

UY38951A|2019-11-12|2021-06-30|Pi Industries Ltd|NEW AGROCHEMICAL COMPOSITION INCLUDING 4- SUBSTITUTED PHENYLAMIDINE COMPOUNDS|

---

EP3708565A1|2020-03-04|2020-09-16|Bayer AG|Pyrimidinyloxyphenylamidines and the use thereof as fungicides|

---

EP3915971A4|2020-12-16|2021-12-01|Bayer Ag|Phenyl-sn-phenylamidines and the use thereof as fungicides|

法律状态:
2018-03-06| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|

---

2018-03-13| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|

---

2018-03-20| B06I| Technical and formal requirements: publication cancelled|Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |

---

2019-06-04| B07A| Technical examination (opinion): publication of technical examination (opinion)|

---

2019-12-03| B06A| Notification to applicant to reply to the report for non-patentability or inadequacy of the application according art. 36 industrial patent law|

---

2020-04-07| B09A| Decision: intention to grant|

---

2020-09-15| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/09/2013, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

---

申请号 | 申请日 | 专利标题

---

EP12183471.7|2012-09-07|

---

EP12183471|2012-09-07|

---

PCT/EP2013/068115|WO2014037314A2|2012-09-07|2013-09-02|Active compound combinations|

---